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About 150 results

ALLMedicine™ Acute Erythroid Leukemia Center

Research & Reviews  75 results

Modeling acute erythroid leukemia via CRISPR.
https://doi.org/10.1182/blood.2020010544
Blood Zhang JP, Cheng T

Mar 25th, 2021 - Modeling acute erythroid leukemia via CRISPR.|2021|Zhang JP,Cheng T,|

Modeling and targeting of erythroleukemia by hematopoietic genome editing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995291
Blood Iacobucci I, Qu C et. al.

Jan 29th, 2021 - Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational spectrum, lack of preclinical models, and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant a...

Chemotherapeutics for Acute Erythroid Leukemia: Research, Present and Future.
https://doi.org/10.2174/1566524021666210121142316
Current Molecular Medicine; Liao Z, Li J et. al.

Jan 21st, 2021 - Acute erythroid leukemia (AEL) is a subtype of acute myeloid leukemia (AML) with features such as accumulation of maturation-arrested erythroblasts. Compared with AML, the progression of AEL is faster and the prognosis to available therapy is wors...

Acute erythroid leukemia is enriched in NUP98 fusions: a report from the Children's Onc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724911
Blood Advances; Chisholm KM, Heerema-McKenney AE et. al.

Dec 7th, 2020 - Acute erythroid leukemia (AEL) is a rare subtype of acute myeloid leukemia (AML) primarily affecting older adults and was previously classified into erythroid/myeloid and pure erythroid subtypes. In this pediatric AEL study, we evaluated morpholog...

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in ac...
https://doi.org/10.1038/s41375-020-01075-3
Leukemia Sportoletti P, Sorcini D et. al.

Nov 7th, 2020 - Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about 4% of AML patients with normal karyotype and are associated with DNMT3a mutations and poor prognosis. Therefore, new anti-leukemia treatments and mouse models...

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Clinicaltrials.gov  75 results

Modeling acute erythroid leukemia via CRISPR.
https://doi.org/10.1182/blood.2020010544
Blood Zhang JP, Cheng T

Mar 25th, 2021 - Modeling acute erythroid leukemia via CRISPR.|2021|Zhang JP,Cheng T,|

Modeling and targeting of erythroleukemia by hematopoietic genome editing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995291
Blood Iacobucci I, Qu C et. al.

Jan 29th, 2021 - Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational spectrum, lack of preclinical models, and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant a...

Chemotherapeutics for Acute Erythroid Leukemia: Research, Present and Future.
https://doi.org/10.2174/1566524021666210121142316
Current Molecular Medicine; Liao Z, Li J et. al.

Jan 21st, 2021 - Acute erythroid leukemia (AEL) is a subtype of acute myeloid leukemia (AML) with features such as accumulation of maturation-arrested erythroblasts. Compared with AML, the progression of AEL is faster and the prognosis to available therapy is wors...

Acute erythroid leukemia is enriched in NUP98 fusions: a report from the Children's Onc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724911
Blood Advances; Chisholm KM, Heerema-McKenney AE et. al.

Dec 7th, 2020 - Acute erythroid leukemia (AEL) is a rare subtype of acute myeloid leukemia (AML) primarily affecting older adults and was previously classified into erythroid/myeloid and pure erythroid subtypes. In this pediatric AEL study, we evaluated morpholog...

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in ac...
https://doi.org/10.1038/s41375-020-01075-3
Leukemia Sportoletti P, Sorcini D et. al.

Nov 7th, 2020 - Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about 4% of AML patients with normal karyotype and are associated with DNMT3a mutations and poor prognosis. Therefore, new anti-leukemia treatments and mouse models...

see more →