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About 6,003 results

ALLMedicine™ Aplastic Anemia Center

Research & Reviews  2,823 results

Eltrombopag in children with severe aplastic anemia.
https://doi.org/10.1002/pbc.29066
Pediatric Blood & Cancer; Lesmana H, Jacobs T et. al.

Apr 15th, 2021 - Immunosuppressive therapy with horse antithymocyte globulin and cyclosporine currently remains the standard therapy for children with severe aplastic anemia (SAA) who lack human leukocyte antigen (HLA)-identical sibling. The thrombopoietin recepto...

Efficacy and safety of eltrombopag in the first-line therapy of severe aplastic anemia ...
https://doi.org/10.1080/08880018.2021.1900475
Pediatric Hematology and Oncology; Jie M, Fu L et. al.

Apr 2nd, 2021 - Eltrombopag is being investigated for the treatment of aplastic anemia (AA) by stimulating hematopoietic stem cell (HSC) proliferation. To evaluate the efficacy and safety of eltrombopag in the first-line therapy of pediatric AA. The present retro...

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia.
https://doi.org/10.1038/s41375-021-01231-3 10.1182/blood-2006-03-010777 10.1056/NEJMra1413485 10.1182/blood-2010-11-314393 10.1182/blood-2011-07-365189 10.1182/blood-2014-05-574889 10.3324/haematol.2013.101642 10.1016/j.cancergen.2015.01.007 10.1056/NEJMoa1414799 10.1038/leu.2017.271 10.1182/blood-2016-01-636381 10.1016/S0140-6736(04)16724-X 10.3324/haematol.2017.176701 10.1186/s13045-016-0261-6 10.1186/1756-8722-5-6 10.3324/haematol.2017.175729 10.1182/bloodadvances.2018022723 10.1016/j.clim.2016.11.018 10.1093/hmg/ddy425 10.1056/NEJMoa1114885 10.1182/blood-2012-06-435297 10.1182/blood-2016-06-724856 10.1182/blood-2013-04-494930 10.1038/nature13038 10.1182/blood.V43.4.473.473 10.1182/blood-2009-04-217604 10.12688/f1000research.6756.1 10.1093/nar/28.1.27 10.1093/nar/gky1015 10.1126/science.aab4082 10.1126/science.aau3879 10.1038/nature19768 10.1056/NEJMoa1709449 10.1073/pnas.1409155111 10.4049/jimmunol.165.10.5729 10.4049/jimmunol.169.4.1984 10.1038/ncomms12484 10.1038/s41375-018-0047-7 10.1182/blood-2018-01-829937 10.1146/annurev-med-051113-024537 10.1146/annurev.immunol.021908.132706 10.1016/j.ccell.2015.03.006 10.1084/jem.20110283 10.3324/haematol.2013.085068 10.4049/jimmunol.1701199 10.1182/bloodadvances.2018027862 10.1056/NEJMoa1408617 10.1056/NEJMoa1701719 10.1126/science.aag1381
Leukemia Lundgren S, Keränen MAI et. al.

Mar 31st, 2021 - The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In immune-mediated aplastic anemia (AA), cytotoxic T-cell expansions are shown to participate...

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Guidelines  2 results

Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the ...
https://doi.org/10.1016/j.bcmd.2015.03.007
Blood Cells, Molecules & Diseases; Barone A, Lucarelli A et. al.

May 15th, 2015 - Acquired aplastic anemia (AA) is a rare heterogeneous disease characterized by pancytopenia and hypoplastic bone marrow. The incidence is 2-3/million inhabitants/year, in Europe, but higher in East Asia. Survival in severe aplastic anemia (SAA) ha...

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellula...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635414
Haematologica Bennett JM, Orazi A

Jan 15th, 2009 - Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three wo...

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Drugs  95 results see all →

Clinicaltrials.gov  2,975 results

Eltrombopag in children with severe aplastic anemia.
https://doi.org/10.1002/pbc.29066
Pediatric Blood & Cancer; Lesmana H, Jacobs T et. al.

Apr 15th, 2021 - Immunosuppressive therapy with horse antithymocyte globulin and cyclosporine currently remains the standard therapy for children with severe aplastic anemia (SAA) who lack human leukocyte antigen (HLA)-identical sibling. The thrombopoietin recepto...

Efficacy and safety of eltrombopag in the first-line therapy of severe aplastic anemia ...
https://doi.org/10.1080/08880018.2021.1900475
Pediatric Hematology and Oncology; Jie M, Fu L et. al.

Apr 2nd, 2021 - Eltrombopag is being investigated for the treatment of aplastic anemia (AA) by stimulating hematopoietic stem cell (HSC) proliferation. To evaluate the efficacy and safety of eltrombopag in the first-line therapy of pediatric AA. The present retro...

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia.
https://doi.org/10.1038/s41375-021-01231-3 10.1182/blood-2006-03-010777 10.1056/NEJMra1413485 10.1182/blood-2010-11-314393 10.1182/blood-2011-07-365189 10.1182/blood-2014-05-574889 10.3324/haematol.2013.101642 10.1016/j.cancergen.2015.01.007 10.1056/NEJMoa1414799 10.1038/leu.2017.271 10.1182/blood-2016-01-636381 10.1016/S0140-6736(04)16724-X 10.3324/haematol.2017.176701 10.1186/s13045-016-0261-6 10.1186/1756-8722-5-6 10.3324/haematol.2017.175729 10.1182/bloodadvances.2018022723 10.1016/j.clim.2016.11.018 10.1093/hmg/ddy425 10.1056/NEJMoa1114885 10.1182/blood-2012-06-435297 10.1182/blood-2016-06-724856 10.1182/blood-2013-04-494930 10.1038/nature13038 10.1182/blood.V43.4.473.473 10.1182/blood-2009-04-217604 10.12688/f1000research.6756.1 10.1093/nar/28.1.27 10.1093/nar/gky1015 10.1126/science.aab4082 10.1126/science.aau3879 10.1038/nature19768 10.1056/NEJMoa1709449 10.1073/pnas.1409155111 10.4049/jimmunol.165.10.5729 10.4049/jimmunol.169.4.1984 10.1038/ncomms12484 10.1038/s41375-018-0047-7 10.1182/blood-2018-01-829937 10.1146/annurev-med-051113-024537 10.1146/annurev.immunol.021908.132706 10.1016/j.ccell.2015.03.006 10.1084/jem.20110283 10.3324/haematol.2013.085068 10.4049/jimmunol.1701199 10.1182/bloodadvances.2018027862 10.1056/NEJMoa1408617 10.1056/NEJMoa1701719 10.1126/science.aag1381
Leukemia Lundgren S, Keränen MAI et. al.

Mar 31st, 2021 - The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In immune-mediated aplastic anemia (AA), cytotoxic T-cell expansions are shown to participate...

see more →

News  89 results

Chimerism and the use of fludarabine associated with secondary graft failure in aplastic anemia
https://www.mdedge.com/hematology-oncology/article/218544/anemia/chimerism-and-use-fludarabine-associated-secondary-graft?channel=39313
Mark S. Lesney

Mar 6th, 2020 - Inferior overall survival was observed in patients with aplastic anemia who had mixed or complete recipient-type chimerism or complete donor chimerism after hematopoietic stem cell transplantation (HSCT), according to the results of a registry dat.

Aplastic Anemia: Diagnosis and Treatment
https://www.mdedge.com/jcomjournal/article/208651/hematology/aplastic-anemia-diagnosis-and-treatment/page/0/4?channel=325

Oct 7th, 2019 - Treatment of Acquired Aplastic Anemia Supportive Care While the workup and treatment plan are being established, attention should be directed at supportive care for prevention of complications. The most common complications leading to death in pat.

Combination Immunotherapy Leading to Severe Hepatotoxicity and Fatal Aplastic Anemia: Case Report and Review of the Literature
https://www.mdedge.com/fedprac/avaho/article/207600/mixed-topics/combination-immunotherapy-leading-severe-hepatotoxicity?channel=53
Dominick A, Fields-Meehan JE et. al.

Sep 5th, 2019 - Background: Dual immune checkpoint blockade (DICB) is utilized for a variety of malignancies. These therapies have a unique and often unpredictable side effect profile compared to conventional chemotherapy.

Aplastic Anemia: Current Treatment
https://www.mdedge.com/hematology-oncology/article/192810/anemia/aplastic-anemia-current-treatment/page/0/2

Jan 23rd, 2019 - Immunosuppressive Therapy For patients without an HLA-matched sibling donor or those who are older than 50 years of age, immunosuppressive therapy is the first-line therapy. ATG and cyclosporine A are the treatments of choice.

Aplastic Anemia: Evaluation and Diagnosis
https://www.mdedge.com/hematology-oncology/article/192807/anemia/aplastic-anemia-evaluation-and-diagnosis/page/0/2

Jan 18th, 2019 - In addition to peripheral blood findings, bone marrow biopsy is essential for the diagnosis, and should demonstrate a markedly hypocellular marrow (cellularity < 25%), occasionally with an increase in T lymphocytes. 7,39 Because marrow cellularity.

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Patient Education  19 results see all →