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About 2,120 results

ALLMedicine™ Atypical Hemolytic Uremic Syndrome Center

Research & Reviews  1,029 results

Atypical hemolytic uremic syndrome due to DGKE mutation and response to eculizumab: les...
https://doi.org/10.1007/s40620-020-00925-8 10.1038/ng.2590 10.1007/s00467-012-2131-y 10.5582/irdr.2014.01001 10.1016/j.molimm.2013.05.224 10.1006/geno.1998.5624 10.1681/ASN.2012090903 10.1016/j.kint.2016.10.005 10.1160/TH15-01-0007 10.1016/j.mayocp.2018.07.008
Journal of Nephrology; Husain D, Barron B et. al.

Mar 22nd, 2021 - Atypical hemolytic uremic syndrome due to DGKE mutation and response to eculizumab: lessons for the clinical nephrologist.|2021|Husain D,Barron B,Barron AG,Sandokji I,Marsenic O,|

Atypical hemolytic uremic syndrome complicating relapsing cryoglobulinemic membranoprol...
https://doi.org/10.1007/s40620-021-00998-z 10.1182/blood-2014-02-558296 10.1182/blood-2009-05-223834 10.1007/s10067-019-04625-y 10.1053/j.gastro.2017.03.006 10.1053/j.gastro.2018.04.024 10.1111/liv.14053 10.1016/j.jceh.2017.11.012 10.3390/pathogens8040176 10.1097/MAJ.0b013e318293cdee
Journal of Nephrology; Gentile M, Rossi GM et. al.

Mar 17th, 2021 - Atypical hemolytic uremic syndrome complicating relapsing cryoglobulinemic membranoproliferative glomerulonephritis despite hepatitis C eradication.|2021|Gentile M,Rossi GM,Delsante M,Zambrano C,Maria AD,|

Atypical hemolytic uremic syndrome and acute tubular necrosis induced by complement fac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982152
Medicine Wu H, Su S et. al.

Mar 17th, 2021 - Atypical hemolytic uremic syndrome (aHUS) is an uncommon and serious disease that manifests hemolytic anemia, thrombocytopenia, and acute kidney injury. Genetic complement abnormalities have been shown to be responsible. Compared with the aHUS cau...

IgM Autoantibodies to Complement Factor H in Atypical Hemolytic Uremic Syndrome.
https://doi.org/10.1681/ASN.2020081224
Journal of the American Society of Nephrology : JASN; Cugno M, Berra S et. al.

Mar 13th, 2021 - Atypical hemolytic uremic syndrome (aHUS), a severe thrombotic microangiopathy, is often related to complement dysregulation, but the pathomechanisms remain unknown in at least 30% of patients. Researchers have described autoantibodies to compleme...

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Guidelines  5 results

Clinical guides for atypical hemolytic uremic syndrome in Japan.
https://doi.org/10.1007/s10157-016-1276-6
Clinical and Experimental Nephrology; Kato H, Nangaku M et. al.

Jul 16th, 2016 - Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In 2013, we developed diagnostic criteria to enable early diagnosis and timely ...

An international consensus approach to the management of atypical hemolytic uremic synd...
https://doi.org/10.1007/s00467-015-3076-8
Pediatric Nephrology (Berlin, Germany); Loirat C, Fakhouri F et. al.

Apr 10th, 2015 - Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g....

Diagnostic criteria for atypical hemolytic uremic syndrome proposed by the Joint Commit...
https://doi.org/10.1007/s10157-013-0911-8
Clinical and Experimental Nephrology; Sawai T, Nangaku M et. al.

Dec 17th, 2013 - Atypical hemolytic uremic syndrome (aHUS) is rare and comprises the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Recently, abnormalities in the mechanisms underlying complement regulation have been focused...

Guideline for the investigation and initial therapy of diarrhea-negative hemolytic urem...
https://doi.org/10.1007/s00467-008-0964-1
Pediatric Nephrology (Berlin, Germany); Ariceta G, Besbas N et. al.

Sep 18th, 2008 - This guideline for the investigation and initial treatment of atypical hemolytic uremic syndrome (HUS) is intended to offer an approach based on opinion, as evidence is lacking. It builds on the current ability to identify the etiology of specific...

SOLIRIS® (ECULIZUMAB)
https://alexion.com/Products/Soliris

Soliris® is a first-in-class terminal complement inhibitor discovered, developed, and commercialized by Alexion. Soliris® works by inhibiting terminal complement, a part of the immune system that, when activated in an uncontrolled manner, plays a...

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Drugs  4 results see all →

Clinicaltrials.gov  1,049 results

Ultomiris - ravulizumab solution, concentrate-Alexion Pharmaceuticals Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9a590d9-0217-43c7-908d-e62a71279791

Apr 5th, 2021 - ULTOMIRIS is indicated for: the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH). the treatment of adults and pediatric patients one month of age and older with atypical hemolytic uremic syndrome (aHUS) to inhibit complem...

Atypical hemolytic uremic syndrome due to DGKE mutation and response to eculizumab: les...
https://doi.org/10.1007/s40620-020-00925-8 10.1038/ng.2590 10.1007/s00467-012-2131-y 10.5582/irdr.2014.01001 10.1016/j.molimm.2013.05.224 10.1006/geno.1998.5624 10.1681/ASN.2012090903 10.1016/j.kint.2016.10.005 10.1160/TH15-01-0007 10.1016/j.mayocp.2018.07.008
Journal of Nephrology; Husain D, Barron B et. al.

Mar 22nd, 2021 - Atypical hemolytic uremic syndrome due to DGKE mutation and response to eculizumab: lessons for the clinical nephrologist.|2021|Husain D,Barron B,Barron AG,Sandokji I,Marsenic O,|

Atypical hemolytic uremic syndrome complicating relapsing cryoglobulinemic membranoprol...
https://doi.org/10.1007/s40620-021-00998-z 10.1182/blood-2014-02-558296 10.1182/blood-2009-05-223834 10.1007/s10067-019-04625-y 10.1053/j.gastro.2017.03.006 10.1053/j.gastro.2018.04.024 10.1111/liv.14053 10.1016/j.jceh.2017.11.012 10.3390/pathogens8040176 10.1097/MAJ.0b013e318293cdee
Journal of Nephrology; Gentile M, Rossi GM et. al.

Mar 17th, 2021 - Atypical hemolytic uremic syndrome complicating relapsing cryoglobulinemic membranoproliferative glomerulonephritis despite hepatitis C eradication.|2021|Gentile M,Rossi GM,Delsante M,Zambrano C,Maria AD,|

Atypical hemolytic uremic syndrome and acute tubular necrosis induced by complement fac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982152
Medicine Wu H, Su S et. al.

Mar 17th, 2021 - Atypical hemolytic uremic syndrome (aHUS) is an uncommon and serious disease that manifests hemolytic anemia, thrombocytopenia, and acute kidney injury. Genetic complement abnormalities have been shown to be responsible. Compared with the aHUS cau...

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News  33 results

FDA Clears Ravulizumab for Atypical Hemolytic Uremic Syndrome
https://www.medscape.com/viewarticle/920120

Oct 20th, 2019 - The US Food and Drug Administration (FDA) has approved ravulizumab (Ultomiris, Alexion Pharmaceuticals) to inhibit complement-mediated thrombotic microangiopathy (TMA) in adults and children age 1 month or older with atypical hemolytic uremic synd...

Meningitis Vaccine No Protection in Rare Diseases
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/66481

Jul 7th, 2017 - Healthcare providers should have a high index of suspicion for meningitis if they are treating patients for two rare blood diseases, even if the patients have been vaccinated, the CDC is warning. The terminal complement inhibitor eculizumab (Solir...

Thrombotic microangiopathies: Similar presentations, different therapies
https://www.mdedge.com/ccjm/article/130154/hematology/thrombotic-microangiopathies-similar-presentations-different?channel=165
Gerald B. Appel, MD

Feb 1st, 2017 - Our knowledge of the pathogenesis of thrombotic microangiopathies has greatly advanced in the last decade, improving the diagnosis and treatment of these diseases. Many conditions involve thrombotic microangiopathies (Table 1).

Blood test may aid diagnosis of HELLP
https://www.mdedge.com/hematology-oncology/article/187295/anemia/blood-test-may-aid-diagnosis-hellp
HT Staff

Jun 1st, 2016 - Pregnant woman Photo by Nina Matthews A blood test developed to diagnose a rare genetic blood cell disorder, atypical hemolytic uremic syndrome (aHUS), may also aid in the diagnosis of HELLP syndrome, a life-threatening high blood pressure conditi.

NORD Publishes Physician Guides to PNH and aHUS
https://www.mdedge.com/internalmedicine/article/105658/rare-diseases/nord-publishes-physician-guides-pnh-and-ahus

Jan 8th, 2016 - Two new physician guides have been published in NORD’s free online series for physicians and other medical professionals on the NORD Physician Guides website. The new guides are the NORD Physician Guide to Paroxysmal Nocturnal Hemoglobinuria (PNH).

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