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About 82 results

ALLMedicine™ Familial LCAT Deficiency Center

Research & Reviews  41 results

Current Status of Familial LCAT Deficiency in Japan.
https://doi.org/10.5551/jat.RV17051
Journal of Atherosclerosis and Thrombosis; Kuroda M, Bujo H et. al.

Apr 19th, 2021 - Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acyl...

CER-001 ameliorates lipid profile and kidney disease in a mouse model of familial LCAT ...
https://doi.org/10.1016/j.metabol.2020.154464
Metabolism: Clinical and Experimental; Ossoli A, Strazzella A et. al.

Dec 14th, 2020 - CER-001 is an HDL mimetic that has been tested in different pathological conditions, but never with LCAT deficiency. This study was designed to investigate whether the absence of LCAT affects the catabolic fate of CER-001, and to evaluate the effe...

Progression of chronic kidney disease in familial LCAT deficiency: a follow-up of the I...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707181
Journal of Lipid Research; Pavanello C, Ossoli A et. al.

Oct 1st, 2020 - Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents ...

Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Nov...
https://doi.org/10.1124/jpet.120.000159
The Journal of Pharmacology and Experimental Therapeutics; Pavanello C, Ossoli A et. al.

Sep 27th, 2020 - Lecithin:cholesterol acyltransferase (LCAT) is a unique plasma enzyme able to esterify cholesterol, and it plays an important role in HDL maturation and promotion of reverse cholesterol transport. Familial LCAT deficiency (FLD; OMIM number 245900)...

Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs ind...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469885
Journal of Lipid Research; Yamamuro D, Yamazaki H et. al.

Jun 20th, 2020 - The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols...

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Clinicaltrials.gov  41 results

Current Status of Familial LCAT Deficiency in Japan.
https://doi.org/10.5551/jat.RV17051
Journal of Atherosclerosis and Thrombosis; Kuroda M, Bujo H et. al.

Apr 19th, 2021 - Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acyl...

CER-001 ameliorates lipid profile and kidney disease in a mouse model of familial LCAT ...
https://doi.org/10.1016/j.metabol.2020.154464
Metabolism: Clinical and Experimental; Ossoli A, Strazzella A et. al.

Dec 14th, 2020 - CER-001 is an HDL mimetic that has been tested in different pathological conditions, but never with LCAT deficiency. This study was designed to investigate whether the absence of LCAT affects the catabolic fate of CER-001, and to evaluate the effe...

Progression of chronic kidney disease in familial LCAT deficiency: a follow-up of the I...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707181
Journal of Lipid Research; Pavanello C, Ossoli A et. al.

Oct 1st, 2020 - Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents ...

Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Nov...
https://doi.org/10.1124/jpet.120.000159
The Journal of Pharmacology and Experimental Therapeutics; Pavanello C, Ossoli A et. al.

Sep 27th, 2020 - Lecithin:cholesterol acyltransferase (LCAT) is a unique plasma enzyme able to esterify cholesterol, and it plays an important role in HDL maturation and promotion of reverse cholesterol transport. Familial LCAT deficiency (FLD; OMIM number 245900)...

Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs ind...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469885
Journal of Lipid Research; Yamamuro D, Yamazaki H et. al.

Jun 20th, 2020 - The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols...

see more →