ALLMedicine™ Hemophilia B Center
Research & Reviews 1,049 results
https://doi.org/10.1097/MPH.0000000000002109
Journal of Pediatric Hematology/oncology; Cuntz F, Deubzer HE et. al.
Mar 4th, 2021 - In the rare co-occurrence of childhood cancer and severe hemophilia, hemostatic management is of paramount therapeutic importance. We present the case of an 11-month-old boy with severe congenital hemophilia B, who was diagnosed with metastatic hi...
https://doi.org/10.1177/0963689721993780
Cell Transplantation; Fagg WS, Liu N et. al.
Mar 4th, 2021 - Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short-term efficacy but can be problematic due to portal hypertension, inflammation, and sinusoidal thrombosis. W...
https://doi.org/10.1182/bloodadvances.2019000405
Blood Advances; Samelson-Jones BJ, Finn JD et. al.
Mar 3rd, 2021 - The high-specific-activity factor IX (FIX) variant Padua (R338L) is the most promising transgene for hemophilia B (HB) gene therapy. Although R338 is strongly conserved in mammalian evolution, amino acid substitutions at this position are underrep...
https://doi.org/10.1182/bloodadvances.2020004071
Blood Advances; Schroeder JA, Chen J et. al.
Mar 1st, 2021 - Gene therapy may lead to a cure for hemophilia B (HB) if it is successful. Data from clinical trials using adeno-associated virus (AAV)-mediated liver-targeted FIX gene therapy are very encouraging. However, this protocol can be applied only to ad...
https://doi.org/10.1111/jth.15281
Journal of Thrombosis and Haemostasis : JTH; Robinson MM, George LA et. al.
Feb 26th, 2021 - Limited information exists regarding the factor IX (FIX) coagulant activity (FIX:C) measured by different assays following FIX-Padua gene therapy. Assess for the first time FIX:C in 5 commonly used coagulation assays in plasma samples from hemophi...
Guidelines 41 results
https://onlinelibrary.wiley.com/doi/10.1111/hae.14139
Haemophilia Shapiro AD
Dec 4th, 2020 - Haemophilia B (HB) is less well studied than haemophilia A (HA); despite similarities between the two inherited bleeding disorders, important differences remain that require further research.
https://onlinelibrary.wiley.com/doi/10.1111/hae.14196
Haemophilia Sackstein P
Nov 7th, 2020 - Hemophilia is the most common X‐linked bleeding disorder, affecting over 1 million individuals throughout the world. Patients are subclassified into mild, moderate and severe disease based on per cent factor activity level.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588779/
Experimental and Therapeutic Medicine; Badulescu OV
Oct 13th, 2020 - Hemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment d...
https://onlinelibrary.wiley.com/doi/10.1111/hae.14046
Haemophilia
Aug 2nd, 2020 - This new edition of the World Federation of Hemophilia (WFH) guidelines for the management of hemophilia comes at an exciting time in the evolution of the diagnosis and treatment of this condition. Since the publication of the second edition in 20...
http://www.ukhcdo.org/wp-content/uploads/2017/03/Guidelines-for-the-management-of-acute-joint-bleeds-and-chronic-synovitis-in-haemophilia.pdf
Haemophilia
Jan 23rd, 2017 - Prior to the availability of clotting factor concentrates, the natural history of arthropathy in severe haemophilia was well described, with recurrent bleeds into joints leading to progressive joint damage and ultimate destruction with associa...
Drugs 31 results see all →
Clinicaltrials.gov 1,169 results
https://doi.org/10.1097/MPH.0000000000002109
Journal of Pediatric Hematology/oncology; Cuntz F, Deubzer HE et. al.
Mar 4th, 2021 - In the rare co-occurrence of childhood cancer and severe hemophilia, hemostatic management is of paramount therapeutic importance. We present the case of an 11-month-old boy with severe congenital hemophilia B, who was diagnosed with metastatic hi...
https://doi.org/10.1177/0963689721993780
Cell Transplantation; Fagg WS, Liu N et. al.
Mar 4th, 2021 - Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short-term efficacy but can be problematic due to portal hypertension, inflammation, and sinusoidal thrombosis. W...
https://doi.org/10.1182/bloodadvances.2019000405
Blood Advances; Samelson-Jones BJ, Finn JD et. al.
Mar 3rd, 2021 - The high-specific-activity factor IX (FIX) variant Padua (R338L) is the most promising transgene for hemophilia B (HB) gene therapy. Although R338 is strongly conserved in mammalian evolution, amino acid substitutions at this position are underrep...
https://doi.org/10.1182/bloodadvances.2020004071
Blood Advances; Schroeder JA, Chen J et. al.
Mar 1st, 2021 - Gene therapy may lead to a cure for hemophilia B (HB) if it is successful. Data from clinical trials using adeno-associated virus (AAV)-mediated liver-targeted FIX gene therapy are very encouraging. However, this protocol can be applied only to ad...
https://doi.org/10.1111/jth.15281
Journal of Thrombosis and Haemostasis : JTH; Robinson MM, George LA et. al.
Feb 26th, 2021 - Limited information exists regarding the factor IX (FIX) coagulant activity (FIX:C) measured by different assays following FIX-Padua gene therapy. Assess for the first time FIX:C in 5 commonly used coagulation assays in plasma samples from hemophi...
News 273 results
https://www.medscape.com/viewarticle/942762
Dec 17th, 2020 - NEW YORK (Reuters Health) - An investigational gene therapy for hemophilia B substantially increased production of the blood-clotting protein factor IX and reduced the number of bleeding episodes and need for prophylactic therapy in a phase-3 tria...
https://onlinelibrary.wiley.com/doi/10.1111/hae.14139
Haemophilia Shapiro AD
Dec 4th, 2020 - Haemophilia B (HB) is less well studied than haemophilia A (HA); despite similarities between the two inherited bleeding disorders, important differences remain that require further research.
https://onlinelibrary.wiley.com/doi/10.1111/hae.14196
Haemophilia Sackstein P
Nov 7th, 2020 - Hemophilia is the most common X‐linked bleeding disorder, affecting over 1 million individuals throughout the world. Patients are subclassified into mild, moderate and severe disease based on per cent factor activity level.
https://reference.medscape.com/viewarticle/939102_2
Oct 21st, 2020 - Hemophilia A is an inherited deficiency of FVIII and an X-linked recessive disorder. Hemophilia B, another recessive disorder, is characterized by a deficiency in factor IX. Hemophilia C is an autosomal recessive disorder in which patients are def...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588779/
Experimental and Therapeutic Medicine; Badulescu OV
Oct 13th, 2020 - Hemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment d...