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About 905 results

ALLMedicine™ Juvenile Myelomonocytic Leukemia Center

Research & Reviews  445 results

Neonatal Leukemia.
https://doi.org/10.1016/j.clp.2020.11.002
Clinics in Perinatology; Brown PA

Feb 15th, 2021 - Neonates are at risk for 3 major forms of leukemia in the first year of life: acute leukemia, juvenile myelomonocytic leukemia, and transient abnormal myelopoiesis associated with Down syndrome. These disorders are rare but generate interest due t...

The impact of social anxiety on feedback-based go and nogo learning.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296011
Psychological Research; Peterburs J, Albrecht C et. al.

Feb 2nd, 2021 - Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood associated with a poor prognosis. Recently, massively parallel sequencing has identified recurrent mutations in the SKI domain of SETBP1 in a variety...

Stem cell origins of JMML.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802372
The Journal of Experimental Medicine; Sundaravel S, Steidl U

Jan 11th, 2021 - In this issue of JEM, Louka et al. (https://doi.org/10.1084/jem.20180853) report that leukemia stem cells lie within the phenotypic hematopoietic stem cell and progenitor cell compartments in juvenile myelomonocytic leukemia (JMML). Furthermore, t...

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802370
The Journal of Experimental Medicine; Louka E, Povinelli B et. al.

Jan 8th, 2021 - Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-c...

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Clinicaltrials.gov  451 results

Neonatal Leukemia.
https://doi.org/10.1016/j.clp.2020.11.002
Clinics in Perinatology; Brown PA

Feb 15th, 2021 - Neonates are at risk for 3 major forms of leukemia in the first year of life: acute leukemia, juvenile myelomonocytic leukemia, and transient abnormal myelopoiesis associated with Down syndrome. These disorders are rare but generate interest due t...

The impact of social anxiety on feedback-based go and nogo learning.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296011
Psychological Research; Peterburs J, Albrecht C et. al.

Feb 2nd, 2021 - Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood associated with a poor prognosis. Recently, massively parallel sequencing has identified recurrent mutations in the SKI domain of SETBP1 in a variety...

Stem cell origins of JMML.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802372
The Journal of Experimental Medicine; Sundaravel S, Steidl U

Jan 11th, 2021 - In this issue of JEM, Louka et al. (https://doi.org/10.1084/jem.20180853) report that leukemia stem cells lie within the phenotypic hematopoietic stem cell and progenitor cell compartments in juvenile myelomonocytic leukemia (JMML). Furthermore, t...

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802370
The Journal of Experimental Medicine; Louka E, Povinelli B et. al.

Jan 8th, 2021 - Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-c...

see more →

News  9 results

Study suggests dasatinib could treat AML, JMML
https://www.mdedge.com/hematology-oncology/article/184841/leukemia-myelodysplasia-transplantation/study-suggests-dasatinib-could-treat
HT Staff

Jul 18th, 2018 - © Universitätsklinikum Freiburg Micrograph showing JMML New research suggests dasatinib could treat certain patients with juvenile myelomonocytic leukemia (JMML) or acute myeloid leukemia (AML). The study showed that TNK2 inhibition has a negative.

DNA methylation may predict outcomes in JMML
https://www.mdedge.com/hematology-oncology/article/185191/cythemias/dna-methylation-may-predict-outcomes-jmml
HT Staff

Jan 11th, 2018 - General Medical Sciences DNA helices Image courtesy of the National Institute of New research suggests DNA methylation may be used to predict how children with juvenile myelomonocytic leukemia (JMML) will respond to treatment. Researchers found th.

Study provides clearer picture of JMML
https://www.mdedge.com/hematology-oncology/article/187540/leukemia-myelodysplasia-transplantation/study-provides-clearer-picture-jmml
HT Staff

Oct 20th, 2015 - Smiling baby Photo by Petr Kratochvil Whole-exome sequencing has provided new insights that may lead to better treatment of juvenile myelomonocytic leukemia (JMML), according to researchers. The group identified new mutations that appear to drive.

Findings may inform design of new treatments for JMML
https://www.mdedge.com/hematology-oncology/article/187565/leukemia-myelodysplasia-transplantation/findings-may-inform-design-new
HT Staff

Oct 9th, 2015 - Colony of iPSCs Image from the Salk Institute Researchers have used induced pluripotent stem cells (iPSCs) to model juvenile myelomonocytic leukemia (JMML) and gain new insight into the disease. The team noted that somatic PTPN11 mutations are kno.

Improved HSCT outcomes due to conditioning or chemo?
https://www.mdedge.com/hematology-oncology/article/187749/leukemia-myelodysplasia-transplantation/improved-hsct-outcomes-due
HT Staff

Jul 28th, 2015 - Cord blood for transplant Photo courtesy of NHS Investigators have reported favorable results of allogeneic hematopoietic stem cell transplant (HSCT) in a small study of patients with juvenile myelomonocytic leukemia (JMML). The team said the posi.

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