ALLMedicine™ Juvenile Myelomonocytic Leukemia Center
Research & Reviews 445 results
https://doi.org/10.1016/j.clp.2020.11.002
Clinics in Perinatology; Brown PA
Feb 15th, 2021 - Neonates are at risk for 3 major forms of leukemia in the first year of life: acute leukemia, juvenile myelomonocytic leukemia, and transient abnormal myelopoiesis associated with Down syndrome. These disorders are rare but generate interest due t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296011
Psychological Research; Peterburs J, Albrecht C et. al.
Feb 2nd, 2021 - Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood associated with a poor prognosis. Recently, massively parallel sequencing has identified recurrent mutations in the SKI domain of SETBP1 in a variety...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802372
The Journal of Experimental Medicine; Sundaravel S, Steidl U
Jan 11th, 2021 - In this issue of JEM, Louka et al. (https://doi.org/10.1084/jem.20180853) report that leukemia stem cells lie within the phenotypic hematopoietic stem cell and progenitor cell compartments in juvenile myelomonocytic leukemia (JMML). Furthermore, t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802370
The Journal of Experimental Medicine; Louka E, Povinelli B et. al.
Jan 8th, 2021 - Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-c...
https://doi.org/10.1007/s00381-020-05013-7 10.1007/s11060-010-0278-6 10.4103/0972-5229.106508 10.1080/02688699844934 10.1016/j.leukres.2008.08.022 10.1007/s00247-018-4149-1 10.1182/blood-2015-01-619734 10.1080/15592294.2019.1583039 10.1016/j.clml.2020.02.003 10.1182/blood.V88.7.2634.bloodjournal8872634 10.1111/j.1365-2141.1995.tb08358.x 10.1111/j.1365-2141.2008.07104.x 10.1080/10245330512331390078 10.1016/j.beha.2020.101171 10.1016/s1726-4901(09)70161-3 10.1182/blood-2014-08-550483 10.1080/17474086.2018.1421937 10.3389/fonc.2020.00484 10.1182/blood-2018-11-844688 10.1182/blood-2010-08-298968 10.1212/WNL.0b013e31828f1899 10.1111/pde.13064 10.1002/1097-0142(197307)32:1<185::aid-cncr2820320128>3.0.co;2-o 10.1016/j.ejca.2004.04.024 10.5137/1019-5149.Jtn.4050-10.2 10.1038/ng.2698 10.1080/08880018.2020.1767244
Child's Nervous System : ChNS : Official Journal of the I... Lambert WA, DiGiuseppe JA et. al.
Jan 6th, 2021 - Juvenile myelomonocytic leukemia (JMML) is a rare childhood hematopoietic disorder typically presenting with hepatosplenomegaly, lymphadenopathy, pallor, fever, and cutaneous findings. The authors report the first case, to our knowledge, of JMML p...
Clinicaltrials.gov 451 results
https://doi.org/10.1016/j.clp.2020.11.002
Clinics in Perinatology; Brown PA
Feb 15th, 2021 - Neonates are at risk for 3 major forms of leukemia in the first year of life: acute leukemia, juvenile myelomonocytic leukemia, and transient abnormal myelopoiesis associated with Down syndrome. These disorders are rare but generate interest due t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296011
Psychological Research; Peterburs J, Albrecht C et. al.
Feb 2nd, 2021 - Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood associated with a poor prognosis. Recently, massively parallel sequencing has identified recurrent mutations in the SKI domain of SETBP1 in a variety...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802372
The Journal of Experimental Medicine; Sundaravel S, Steidl U
Jan 11th, 2021 - In this issue of JEM, Louka et al. (https://doi.org/10.1084/jem.20180853) report that leukemia stem cells lie within the phenotypic hematopoietic stem cell and progenitor cell compartments in juvenile myelomonocytic leukemia (JMML). Furthermore, t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802370
The Journal of Experimental Medicine; Louka E, Povinelli B et. al.
Jan 8th, 2021 - Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-c...
https://doi.org/10.1007/s00381-020-05013-7 10.1007/s11060-010-0278-6 10.4103/0972-5229.106508 10.1080/02688699844934 10.1016/j.leukres.2008.08.022 10.1007/s00247-018-4149-1 10.1182/blood-2015-01-619734 10.1080/15592294.2019.1583039 10.1016/j.clml.2020.02.003 10.1182/blood.V88.7.2634.bloodjournal8872634 10.1111/j.1365-2141.1995.tb08358.x 10.1111/j.1365-2141.2008.07104.x 10.1080/10245330512331390078 10.1016/j.beha.2020.101171 10.1016/s1726-4901(09)70161-3 10.1182/blood-2014-08-550483 10.1080/17474086.2018.1421937 10.3389/fonc.2020.00484 10.1182/blood-2018-11-844688 10.1182/blood-2010-08-298968 10.1212/WNL.0b013e31828f1899 10.1111/pde.13064 10.1002/1097-0142(197307)32:1<185::aid-cncr2820320128>3.0.co;2-o 10.1016/j.ejca.2004.04.024 10.5137/1019-5149.Jtn.4050-10.2 10.1038/ng.2698 10.1080/08880018.2020.1767244
Child's Nervous System : ChNS : Official Journal of the I... Lambert WA, DiGiuseppe JA et. al.
Jan 6th, 2021 - Juvenile myelomonocytic leukemia (JMML) is a rare childhood hematopoietic disorder typically presenting with hepatosplenomegaly, lymphadenopathy, pallor, fever, and cutaneous findings. The authors report the first case, to our knowledge, of JMML p...
News 9 results
https://www.mdedge.com/hematology-oncology/article/184841/leukemia-myelodysplasia-transplantation/study-suggests-dasatinib-could-treat
HT Staff
Jul 18th, 2018 - © Universitätsklinikum Freiburg Micrograph showing JMML New research suggests dasatinib could treat certain patients with juvenile myelomonocytic leukemia (JMML) or acute myeloid leukemia (AML). The study showed that TNK2 inhibition has a negative.
https://www.mdedge.com/hematology-oncology/article/185191/cythemias/dna-methylation-may-predict-outcomes-jmml
HT Staff
Jan 11th, 2018 - General Medical Sciences DNA helices Image courtesy of the National Institute of New research suggests DNA methylation may be used to predict how children with juvenile myelomonocytic leukemia (JMML) will respond to treatment. Researchers found th.
https://www.mdedge.com/hematology-oncology/article/187540/leukemia-myelodysplasia-transplantation/study-provides-clearer-picture-jmml
HT Staff
Oct 20th, 2015 - Smiling baby Photo by Petr Kratochvil Whole-exome sequencing has provided new insights that may lead to better treatment of juvenile myelomonocytic leukemia (JMML), according to researchers. The group identified new mutations that appear to drive.
https://www.mdedge.com/hematology-oncology/article/187565/leukemia-myelodysplasia-transplantation/findings-may-inform-design-new
HT Staff
Oct 9th, 2015 - Colony of iPSCs Image from the Salk Institute Researchers have used induced pluripotent stem cells (iPSCs) to model juvenile myelomonocytic leukemia (JMML) and gain new insight into the disease. The team noted that somatic PTPN11 mutations are kno.
https://www.mdedge.com/hematology-oncology/article/187749/leukemia-myelodysplasia-transplantation/improved-hsct-outcomes-due
HT Staff
Jul 28th, 2015 - Cord blood for transplant Photo courtesy of NHS Investigators have reported favorable results of allogeneic hematopoietic stem cell transplant (HSCT) in a small study of patients with juvenile myelomonocytic leukemia (JMML). The team said the posi.
