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ALLMedicine™ Primary Central Nervous System Lymphoma Center

Research & Reviews  1,455 results

Treatment patterns and disease course of previously untreated Primary Central Nervous S...
https://doi.org/10.1111/ejh.13639
European Journal of Haematology; Sieg N, Naendrup JH et. al.

May 7th, 2021 - Primary Central Nervous System Lymphoma (PCNSL) is a rare type of aggressive lymphoma of the central nervous system. Treatment strategies improved significantly over the past decades, differ regionally but mainly consist of rituximab and high-dose...

Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central N...
https://doi.org/10.1001/jamaoncol.2021.1074
JAMA Oncology; Scordo M, Wang TP et. al.

May 6th, 2021 - Primary central nervous system lymphoma (PCNSL) requires induction and consolidation to achieve potential cure. High-dose therapy and autologous hematopoietic cell transplant (AHCT) is an accepted and effective consolidation strategy for PCNSL, bu...

Should Thiotepa-Based Regimens Be the New Transplant Conditioning Strategy for Primary ...
https://doi.org/10.1001/jamaoncol.2021.1056
JAMA Oncology; Hill JM, Meehan KR

May 6th, 2021 - Should Thiotepa-Based Regimens Be the New Transplant Conditioning Strategy for Primary Central Nervous System Lymphoma?|2021|Hill JM,Meehan KR,|

Methylated markers accurately distinguish primary central nervous system lymphomas (PCN...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097855
Clinical Epigenetics; Downs BM, Ding W et. al.

May 6th, 2021 - Definitive diagnosis of primary central nervous system lymphoma (PCNSL) requires invasive surgical brain biopsy, causing treatment delays. In this paper, we identified and validated tumor-specific markers that can distinguish PCNSL from other CNS ...

Diagnostic Performance of Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomogra...
https://doi.org/10.1016/j.clml.2021.03.011
Clinical Lymphoma, Myeloma & Leukemia; Gupta T, Manjali JJ et. al.

May 5th, 2021 - This review aimed to assess diagnostic performance of 18F-flouro-deoxy-glucose positron emission tomography (FDG-PET) with or without computed tomography (CT) scan in primary central nervous system lymphoma (PCNSL). Eligible studies reporting diag...

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Clinicaltrials.gov  1,473 results

Treatment patterns and disease course of previously untreated Primary Central Nervous S...
https://doi.org/10.1111/ejh.13639
European Journal of Haematology; Sieg N, Naendrup JH et. al.

May 7th, 2021 - Primary Central Nervous System Lymphoma (PCNSL) is a rare type of aggressive lymphoma of the central nervous system. Treatment strategies improved significantly over the past decades, differ regionally but mainly consist of rituximab and high-dose...

Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central N...
https://doi.org/10.1001/jamaoncol.2021.1074
JAMA Oncology; Scordo M, Wang TP et. al.

May 6th, 2021 - Primary central nervous system lymphoma (PCNSL) requires induction and consolidation to achieve potential cure. High-dose therapy and autologous hematopoietic cell transplant (AHCT) is an accepted and effective consolidation strategy for PCNSL, bu...

Should Thiotepa-Based Regimens Be the New Transplant Conditioning Strategy for Primary ...
https://doi.org/10.1001/jamaoncol.2021.1056
JAMA Oncology; Hill JM, Meehan KR

May 6th, 2021 - Should Thiotepa-Based Regimens Be the New Transplant Conditioning Strategy for Primary Central Nervous System Lymphoma?|2021|Hill JM,Meehan KR,|

Methylated markers accurately distinguish primary central nervous system lymphomas (PCN...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097855
Clinical Epigenetics; Downs BM, Ding W et. al.

May 6th, 2021 - Definitive diagnosis of primary central nervous system lymphoma (PCNSL) requires invasive surgical brain biopsy, causing treatment delays. In this paper, we identified and validated tumor-specific markers that can distinguish PCNSL from other CNS ...

Diagnostic Performance of Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomogra...
https://doi.org/10.1016/j.clml.2021.03.011
Clinical Lymphoma, Myeloma & Leukemia; Gupta T, Manjali JJ et. al.

May 5th, 2021 - This review aimed to assess diagnostic performance of 18F-flouro-deoxy-glucose positron emission tomography (FDG-PET) with or without computed tomography (CT) scan in primary central nervous system lymphoma (PCNSL). Eligible studies reporting diag...

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News  21 results

Primary CNS lymphoma: R-CHOP hits back
https://www.mdedge.com/hematology-oncology/article/210341/b-cell-lymphoma/primary-cns-lymphoma-r-chop-hits-back?channel=59374
Vanja Zeremski, MD, Thomas Fischer, MD

Oct 17th, 2019 - Primary central nervous system lymphoma (PCNSL) is a rare and aggressive form of non-Hodgkin lymphoma solely confined to the CNS. The majority of PCNSL histologically presents as diffuse large B-cell lymphoma (DLBCL).

Review of Radiologic Considerations in an Immunocompetent Patient With Primary Central Nervous System Lymphoma
https://www.mdedge.com/fedprac/avaho/article/206078/lymphoma-plasma-cell-disorders/review-radiologic-considerations/page/0/1?channel=263

Aug 7th, 2019 - Discussion The workup of altered mental status, focal neurologic deficits, headaches, or other neurologic conditions often begins with a noncontrast CT scan. On CT, PCNSL generally appears isodense to hyperdense to gray matter, but appearance is v.

High-dose MTX-based chemo is well tolerated in older PCNSL patients
https://www.mdedge.com/hematology-oncology/article/199565/b-cell-lymphoma/high-dose-mtx-based-chemo-well-tolerated-older?channel=59374
Will Pass

Apr 24th, 2019 - GLASGOW – Most older patients with primary central nervous system lymphoma (PCNSL) can tolerate high-dose methotrexate-based chemotherapy and achieve similar outcomes as younger and fitter patients, according to a retrospective analysis of 244 pat.

Rituximab boosts survival in primary CNS lymphoma
https://www.mdedge.com/hematology-oncology/article/197142/b-cell-lymphoma/rituximab-boosts-survival-primary-cns-lymphoma?channel=59374
Will Pass

Mar 22nd, 2019 - For patients with primary central nervous system lymphoma (PCNSL), adding rituximab to combination high-dose methotrexate and temozolomide significantly boosted the 5-year overall survival rate, according to a retrospective study. The triplet comb.

New PCNSL guidelines emphasize importance of patient fitness
https://www.mdedge.com/hematology-oncology/article/190772/lymphoma-plasma-cell-disorders/new-pcnsl-guidelines-emphasize-importance?channel=49434
Jennie Smith

Dec 2nd, 2018 - Image by Michael Bonert Micrograph showing PCNSL New guidelines on the diagnosis and management of patients with primary central nervous system lymphoma (PCNSL) emphasize prompt diagnosis, aggressive treatment whenever possible, and multidisciplin.

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Patient Education  1 results see all →