ALLMedicine™ Acquired Hemophilia Center
Research & Reviews 214 results
https://doi.org/10.1016/j.jtha.2022.10.004
Journal of Thrombosis and Haemostasis : JTH; Shima M, Amano K et. al.
Jan 26th, 2023 - Emicizumab is a bispecific antibody that mimics the cofactor function of activated factor (F) VIII. It prevents bleeds in patients with congenital hemophilia A regardless of the inhibitor status; however, no prospective clinical studies have been ...
https://doi.org/10.3324/haematol.2022.281895
Haematologica Bou-Jaoudeh M, Delignat S et. al.
Jan 20th, 2023 - Neutralizing anti-factor VIII (FVIII) antibodies, known as FVIII inhibitors, represent a major drawback of replacement therapy in persons with congenital hemophilia A (PwHA), rendering further infusions of FVIII ineffective. FVIII inhibitors can a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893059
Clinical and Applied Thrombosis/hemostasis : Official Jou... Liu Y, Ruan X et. al.
Jan 20th, 2023 - Immunosuppressive therapy (IST) for acquired hemophilia A (AHA) results in remission within days to months in 60% to 80% of patients. However, little is known regarding the predictors of response. This study aimed to identify the factors that infl...
https://doi.org/10.1182/blood.2021014766
Blood Samuelson Bannow BT, Konkle BA
Jan 19th, 2023 - Excessive bleeding is relatively common in adult inpatients, whether as the primary reason for admission or developing during the hospital stay. Common causes include structural issues, medication effects and systemic illnesses but occasionally un...
https://clinicaltrials.gov/ct2/show/NCT04188639
Jan 9th, 2023 - This study is an international, multicenter, open-label, single arm, prospective clinical trial and will evaluate the efficacy of prophylactic emicizumab administered on a scheduled basis to prevent bleeds in patients with acquired hemophilia A (A...
Guidelines 1 results
https://doi.org/10.3324/haematol.2008.001743
Haematologica Huth-Kühne A, Baudo F et. al.
Apr 2nd, 2009 - Acquired hemophilia A (AHA) is a rare bleeding disorder characterized by autoantibodies directed against circulating coagulation factor (F) VIII. Typically, patients with no prior history of a bleeding disorder present with spontaneous bleeding an...
Drugs 9 results see all →
Clinicaltrials.gov 11 results
https://clinicaltrials.gov/ct2/show/NCT04188639
Jan 9th, 2023 - This study is an international, multicenter, open-label, single arm, prospective clinical trial and will evaluate the efficacy of prophylactic emicizumab administered on a scheduled basis to prevent bleeds in patients with acquired hemophilia A (A...
https://clinicaltrials.gov/ct2/show/NCT04580407
Dec 29th, 2022 - The main aims of the study are to learn if TAK-672 can control bleeds in participants with acquired hemophilia A and if the participants have side effects from TAK-672. Acquired hemophilia A is when people's immune system attacks specific proteins...
https://clinicaltrials.gov/ct2/show/NCT05345197
Sep 10th, 2022 - Patients with AHA who are eligible will receive two loading doses of the study drug, emicizumab (6mg/kg on day 1 and 3 mg/kg on day 2) followed by once weekly subcutaneous emicizumab (1.5 mg/kg). Immunosuppression will be given concurrently as per...
https://clinicaltrials.gov/ct2/show/NCT04805021
Jan 11th, 2022 - Acquired hemophilia A is a rare condition of hemostasis secondary to the development of antibodies against factor VIII. This is a potentially serious pathology that can be life-threatening due to the major risk of bleeding caused by the sometimes ...
https://clinicaltrials.gov/ct2/show/NCT02610127
Aug 5th, 2021 - This study is a multi-center, uncontrolled, open-label, non-interventional post-marketing safety surveillance study to describe the use of Obizur in patients with acquired hemophilia A (AHA), and secondarily, where data are available, to describe ...
News 25 results
https://www.mdedge.com/dermatology/article/256573/mixed-topics/rituximab-acquired-hemophilia-setting-bullous-pemphigoid
Maria C. Bell, MD, Daniel C. Grove, MD et. al.
Jul 28th, 2022 - To the Editor: Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by the formation of antihemidesmosomal antibodies, resulting in tense bullae concentrated on the extremities and trunk that often are preceded by a pruritic u.
https://www.medscape.com/viewarticle/972442
Apr 20th, 2022 - Because they have detected sluggishness in hospital diagnoses, researchers have developed an algorithm to help clinicians determine whether patients have acquired hemophilia A (AHA), a rare bleeding disorder that mainly affects elderly men with me...
https://www.mdedge.com/hematology-oncology/article/253869/bleeding-disorders/time-blood-researchers-devise-shortcut-aha
Randy Dotinga
Apr 18th, 2022 - Because they have detected sluggishness in hospital diagnoses, researchers have developed an algorithm to help clinicians determine whether patients have acquired hemophilia A (AHA), a rare bleeding disorder that mainly affects elderly men with me.
https://www.medscape.com/viewarticle/968826
Feb 18th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Four cases of acquired hemophilia A (AHA) identified after SARS-CoV-2 immunizations in a province in northern Italy caught the attention of resear...
https://www.mdedge.com/hematology-oncology/article/251919/bleeding-disorders/post-covid-vaccine-aha-cases-raise-eyebrows
Sharon Worcester
Feb 17th, 2022 - Four cases of acquired hemophilia A (AHA) identified after SARS-CoV-2 immunizations in a province in northern Italy caught the attention of researchers, who stressed that the cases are “unusual,” but not necessarily caused by vaccination. “The ove.