About 43,960 results

ALLMedicine™ Acute Myeloid Leukemia Center

Research & Reviews  13,096 results

Venetoclax in acute myeloid leukemia.
Expert Opinion on Investigational Drugs; Bruzzese A, Martino EA et. al.

Mar 19th, 2023 - Venetoclax in acute myeloid leukemia.|2023|Bruzzese A,Martino EA,Mendicino F,Lucia E,Olivito V,|

Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for ...
Cancer Immunology, Immunotherapy : CII; Cheng J, Ge T et. al.

Mar 19th, 2023 - Acute myeloid leukemia (AML) treatment remains challenging. CD70 was reported as a promising AML-specific antigen. Preclinically, CAR T-cell with single-chain-variable fragment (scFv) or truncated CD27 targeting CD70 has been reported to treat AML...

Progression to B acute lymphoblastic leukemia in 8p11 myeloproliferative syndrome with ...
International Journal of Hematology; Nakamura F, Seo S et. al.

Mar 18th, 2023 - 8p11 myeloproliferative syndrome is a rare hematological malignancy caused by the translocation of FGFR1. Patients present with a myeloproliferative neoplasm that frequently transforms into acute myeloid leukemia or T-lymphoblastic lymphoma/leukem...

Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor-Alpha Receptor 1 Signaling Pathway Le...
Journal of Interferon & Cytokine Research : the Official ... Ben Khoud M, Jouy N et. al.

Mar 18th, 2023 - Acute myeloid leukemia (AML) is characterized by an increased proliferation and loss of differentiation of hematopoietic myeloid progenitors or precursors. Studies performed in AML-affected patients revealed a T cell deficiency characterized by a ...

FOXP1 regulates oxidative stress, SIRT1 expression, and resistance to chemotherapies in...
Blood Advances; Levavasseur F, Oussous S et. al.

Mar 18th, 2023 - Transcription factor Forkhead box P1 (FOXP1) belongs to the same protein family as the FOXOs that are well-known regulators of murine hematopoietic stem progenitor cell (HSPC) maintenance by dampening oxidative stress. FOXP1 and FOXOs can play opp...

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Guidelines  13 results

NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.
Journal of the National Comprehensive Cancer Network : JN... Pollyea DA, Bixby D et. al.

Jan 7th, 2021 - The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regard...

Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myel...
Biology of Blood and Marrow Transplantation : Journal of ... Dholaria B, Savani BN et. al.

Sep 24th, 2020 - The role of hematopoietic cell transplantation (HCT) in the management of newly diagnosed adult acute myeloid leukemia (AML) is reviewed and critically evaluated in this evidence-based review. An AML expert panel, consisting of both transplant and...

Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients W...
Journal of Clinical Oncology : Official Journal of the Am... Lehrnbecher T, Fisher BT et. al.

May 28th, 2020 - To develop a clinical practice guideline for systemic antifungal prophylaxis in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients. Recommendations were developed by an international multidisciplinary pane...

NCCN Guidelines Insights: Myeloproliferative Neoplasms, Version 2.2018.
Journal of the National Comprehensive Cancer Network : JN... Mesa RA, Jamieson C et. al.

Oct 7th, 2017 - Myeloproliferative neoplasms (MPNs) are a group of heterogeneous disorders of the hematopoietic system that include myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET). PV and ET are characterized by significant thromboh...

Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JN... O'Donnell MR, Tallman MS et. al.

Jul 9th, 2017 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. This portion of the NCCN Guidelines for AML focuses on management and p...

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Drugs  33 results see all →

Clinicaltrials.gov  1,760 results

Integrating Geriatric Assessment and Genetic Profiling to Personalize Therapy Selection in Older Adults With Acute Myeloid Leukemia

Mar 10th, 2023 - PRIMARY OBJECTIVES: I. To determine the rate of complete remission and mortality at 90 days in the entire cohort of older patients (>= 60 years) with newly diagnosed acute myeloid leukemia (AML) who receive clinicogenetic risk-stratified therapy a...

A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia

Mar 10th, 2023 - JZP025-101 is an open-label, multicenter, multi-arm, nonrandomized phase 1b master trial to determine the recommended phase 2 dose (RP2D) of CPX-351 when administered in combination with various targeted agents in previously untreated subjects wit...

Ruxolitinib in Patients With Myelofibrosis

Mar 10th, 2023 - Myelofibrosis (MF) is a clonal disorder of the pluripotent hematopoietic stem cell in which the abnormal stem cell population releases several cytokines and growth factors into the bone marrow microenvironment, it is pathologically characterized b...

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Mar 10th, 2023 - PRIMARY OBJECTIVE: I. To compare the 1-year cumulative incidence of severe Graft Versus Host Disease (GVHD) (from day of HCT) defined as grade III-IV acute GVHD (aGVHD) and/or chronic GVHD (cGVHD) that requires systemic immunosuppression and to co...

Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT

Mar 10th, 2023 - The purpose of this study is to evaluate the efficacy and safety of mocravimod as an adjunctive and maintenance treatment in adult acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic cell transplantation (HCT).

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News  2,666 results

Jimmy Carter's Melanoma; Post-Op Osimertinib Boosts OS; $83K for Unproven Therapy

Mar 9th, 2023 - How the successful use of pembrolizumab (Keytruda) for former President Jimmy Carter's metastatic melanoma put "immunotherapy on the map." (Washington Post) A study of molecular changes observed in the breast tissue of transgender men undergoing a...

Maternal Infection May Play Role in Child's Leukemia

Feb 20th, 2023 - Maternal genitourinary tract infections during pregnancy were linked to the development of leukemia in offspring, a Danish nationwide study found. Children born to a mother who experienced any kind of infection during pregnancy had increased risk ...

Toxin Exposure and Acute Myeloid Leukemia in Veterans
Timothy O'Brien, MD

Feb 8th, 2023 - Members of the United States military who served in Vietnam between 1961 and 1971 risked exposure to the weaponized chemical defoliant known as Agent Orange. Among the components of Agent Orange, benzene and tetrachlorodibenzo-p-dioxin (TCDD) are.

ODAC to Review Lymphoma Drug; Tobacco Control; Artificial Skin Aids Cancer Studies

Jan 27th, 2023 - The FDA announced that the Oncologic Drugs Advisory Committee (ODAC) will meet March 9 to review the accelerated approval of polatuzumab vedotin (Polivy) plus rituximab (Rituxan) and chemotherapy for untreated diffuse large B-cell lymphoma. Jansse...

Rise in Cervical Cancer Mortality; Drug Active in Kids' Glioma; Vit D and Melanoma

Jan 13th, 2023 - A California study showed a concerning increase in cervical cancer mortality among women 65 or older, the age at which routine screening is no longer recommended. (UC Davis Comprehensive Cancer Center, Cancer Epidemiology, Biomarkers & Prevention)...

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Patient Education  16 results see all →