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About 2,763 results

ALLMedicine™ Acute Promyelocytic Leukemia Center

Research & Reviews  1,001 results

Relapsed/refractory acute promyelocytic leukemia with RARA-LBD region mutation was salv...
https://doi.org/10.1097/MD.0000000000028076
Medicine Li Y, Yu J et. al.

Jan 21st, 2022 - Acute promyelocytic leukemia (APL) is one of the most curable cancers. However, relapse of the disease is a difficult issue in clinical practice and it remains a great challenge that patients have a poor effect of conventional treatment in the cli...

Arsenic compounds induce apoptosis by activating the MAPK and caspase pathways in FaDu ...
https://doi.org/10.3892/ijo.2022.5308
International Journal of Oncology; Wu SZ, Lan YY et. al.

Jan 15th, 2022 - For a number of years, oral cancer has remained in the top ten most common types of cancer, with an incidence rate that is steadily increasing. In total, ~75% oral cancer cases are associated with lifestyle factors, including uncontrolled alcohol ...

Predictive factors for differentiating thrombohemorrhagic disorders in high-risk acute ...
https://doi.org/10.1016/j.thromres.2021.12.020
Thrombosis Research; Xiao M, Zhou P et. al.

Jan 9th, 2022 - Acute promyelocytic leukemia (APL) is often accompanied by potentially fatal coagulopathy, especially in high-risk APL. Bleeding, particularly severe bleeding is the leading cause of early death (ED). Meanwhile, thrombosis, the other major coagulo...

'FLT3-ITD Mutation Does Not Influence Survival Outcome in Adult Acute Promyelocytic Leu...
https://doi.org/10.1016/j.clml.2021.12.007
Clinical Lymphoma, Myeloma & Leukemia; Deka RR, Naseem S et. al.

Jan 7th, 2022 - NPM1 and FLT3-ITD are frequently mutated genes in acute myeloid leukemia. We studied clinico-hematological profile and survival outcome of adult acute promyelocytic leukemia (APL) patients harboring these mutations. De novo APL cases (> 12 years),...

Acute promyelocytic leukemia with Chediak-Higashi like giant granules.
https://doi.org/10.1182/blood.2021013975
Blood Zhang YH, Han X

Jan 7th, 2022 - Acute promyelocytic leukemia with Chediak-Higashi like giant granules.|2022|Zhang YH,Han X,|

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Guidelines  2 results

NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.
https://doi.org/10.6004/jnccn.2021.0002
Journal of the National Comprehensive Cancer Network : JN... Pollyea DA, Bixby D et. al.

Jan 7th, 2021 - The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regard...

Acute myeloid leukemia, version 2.2013.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161234
Journal of the National Comprehensive Cancer Network : JN... O'Donnell MR, Tallman MS et. al.

Sep 14th, 2013 - These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Acute Myeloid Leukemia and discuss the clinical evidence that support the recommendations. The updates described in this article focus on the acute promyelocyt...

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Drugs  13 results see all →

Clinicaltrials.gov  28 results

A Study for Oral SY-2101 for Participants With Acute Promyelocytic Leukemia
https://clinicaltrials.gov/ct2/show/NCT04996030

Nov 12th, 2021 - This study includes 3 parts: during one part, enrolled participants will receive a single dose of IV ATO, and a week later a single dose of SY-2101 either in the fed or fasted condition, and a week after that, a single dose of SY-2101 in the fed o...

The Effect of Arsenic Trioxide on Eliminating HIV-1 Reservoir Combined With cART
https://clinicaltrials.gov/ct2/show/NCT03980665

Jul 20th, 2021 - Although combined antiretroviral therapy (cART) could control human immunodeficiency virus type 1 (HIV-1) infection, the persistence of HIV-1 viral reservoir make it extremely difficult to achieving cure of AIDS. The shock and kill strategy has be...

Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia
https://clinicaltrials.gov/ct2/show/NCT01409161

Apr 6th, 2021 - PRIMARY OBJECTIVES: I. Assess whether a combination of all-trans retinoic acid (ATRA [tretinoin]), and arsenic trioxide (ATO) can produce long-term event-free survival in patients with low-risk untreated acute promyelocytic leukemia (APL). II. Ass...

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia
https://clinicaltrials.gov/ct2/show/NCT00866918

Mar 25th, 2021 - PRIMARY OBJECTIVES: I. To decrease the total anthracycline dose from the best current published results in standard risk childhood acute promyelocytic leukemia (APL) while still maintaining a comparable event-free survival (EFS). SECONDARY OBJECTI...

Study of Arsenic Trioxide in Small Cell Lung Cancer
https://clinicaltrials.gov/ct2/show/NCT01470248

Feb 17th, 2021 - The purpose of this study is to study the effect of an anticancer drug, Arsenic Trioxide, in patients with small cell lung cancer who have failed at least one standard chemotherapy regimen as well as patients who are unable to tolerate the standar...

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News  61 results

Magrolimab Plus Various Anti-Leukemia Therapies Being Studied for Efficacy in AML
https://www.onclive.com/view/magrolimab-plus-various-anti-leukemia-therapies-being-studied-for-efficacy-in-aml

Dec 14th, 2021 - Magrolimab plus combinations of various anti-leukemia therapies are being investigated for efficacy as options for frontline, relapsed/refractory, or maintenance treatment of patients with acute myeloid leukemia (AML), according to a poster presen...

Precision medicine: A new approach to AML, other blood cancers
https://www.mdedge.com/hematology-oncology/article/249816/aml
Caleb Rans, PharmD

Dec 12th, 2021 - The emergence of precision medicine has ushered in a groundbreaking era for the treatment of myeloid malignancies, with the ability to integrate individual molecular data into patient care. Over the past decade, insights from research focusing on.

'Shocking' Lack of Lifesaving Leukemia Drug at US Hospitals
https://www.medscape.com/viewarticle/964213

Dec 6th, 2021 - A drug crucial for the emergency management of acute promyelocytic leukemia (APL) simply isn't stocked by many US hospitals, according to a recent report in the Journal of the National Comprehensive Cancer Network. The drug — all-trans retinoic ac...

Quizartinib/Chemo Shows Superior OS Benefit Over Chemo Alone in Newly Diagnosed FLT3-ITD+ AML
https://www.onclive.com/view/quizartinib-chemo-shows-superior-os-benefit-over-chemo-alone-in-newly-diagnosed-flt3-itd-aml

Nov 19th, 2021 - The addition of quizartinib to standard induction and consolidation chemotherapy followed by quizartinib monotherapy resulted in a statistically significant and clinically meaningful improvement in overall survival (OS) vs standard chemotherapy al...

'Remarkable' Results in Pediatric Acute Promyelocytic Leukemia
https://www.medscape.com/viewarticle/962943

Nov 15th, 2021 - "Remarkable" results with a novel treatment regimen in pediatric acute promyelocytic leukemia (APL) have been reported by researchers at the National Cancer Institute (NCI). Two-year event free survival (EFS) with the regimen was 98% and overall s...

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