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About 55 results

ALLMedicine™ Adenosine Deaminase 2 Deficiency Center

Research & Reviews  22 results

Genotype and Phenotype of Adenosine Deaminase 2 Deficiency: a Report from Saudi Arabia.
https://doi.org/10.1007/s10875-022-01364-9
Journal of Clinical Immunology; Alabbas F, Alanzi T et. al.

Oct 15th, 2022 - Adenosine deaminase 2 deficiency (DADA2), a rare and potentially fatal systemic autoinflammatory disease, is characterized by low or lack of ADA2 activity due to ADA2 mutations. DADA2 symptoms are variable and include vasculitis, immunodeficiency,...

Polyarteritis nodosa: an evolving primary systemic vasculitis.
https://doi.org/10.1080/00325481.2022.2088940
Postgraduate Medicine; Springer JM, Byram K

Jun 17th, 2022 - Polyarteritis nodosa (PAN) is a primary form of vasculitis characterized by inflammation of primarily medium-sized arteries. Several key events have shaped the current spectrum of the disease including the separation of a subgroup with microscopic...

Hematopoietic stem cell transplantation in systemic autoinflammatory diseases - the fir...
https://doi.org/10.1080/1744666X.2022.2078704
Expert Review of Clinical Immunology; Signa S, Dell'Orso G et. al.

May 17th, 2022 - Primary immune regulatory disorders encompass a range of clinical conditions caused by different defects of immune regulatory mechanisms, including systemic autoinflammatory diseases (AIDs). Allogeneic hematopoietic stem cell transplantation may b...

Type I interferon-related kidney disorders.
https://doi.org/10.1016/j.kint.2022.02.031
Kidney International; Lodi L, Mastrolia MV et. al.

Mar 28th, 2022 - Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-...

TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2).
https://doi.org/10.1016/j.jaci.2021.10.030
The Journal of Allergy and Clinical Immunology; Deuitch NT, Yang D et. al.

Nov 16th, 2021 - Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disorder caused by a loss of functional ADA2 protein. TNF inhibition (TNFi) has proven to be highly effective in treating inflammatory manifestations. We sough...

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