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ALLMedicine™ Adenosine Deaminase 2 Deficiency Center

Research & Reviews  18 results

TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2).
https://doi.org/10.1016/j.jaci.2021.10.030
The Journal of Allergy and Clinical Immunology; Deuitch NT, Yang D et. al.

Nov 16th, 2021 - Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disorder caused by a loss of functional ADA2 protein. TNF inhibition (TNFi) has proven to be highly effective in treating inflammatory manifestations. We sough...

Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405196
Blood Advances; Zoccolillo M, Brigida I et. al.

Aug 24th, 2021 - Adenosine deaminase 2 deficiency (DADA2) is a rare inherited disorder that is caused by autosomal recessive mutations in the ADA2 gene. Clinical manifestations include early-onset lacunar strokes, vasculitis/vasculopathy, systemic inflammation, im...

Another Exciting Data-HCT Successfully Cured Patients with DADA2 : A commentary on "Hem...
https://doi.org/10.1007/s10875-021-01121-4 10.1007/s10875-018-0525-8 10.1016/j.jaci.2019.12.908 10.1056/NEJMc1801927 10.1182/blood-2017-07-798660 10.1007/s10875-017-0449-8 10.1136/annrheumdis-2016-210802
Journal of Clinical Immunology; Yamashita M, Morio T

Aug 15th, 2021 - Another Exciting Data-HCT Successfully Cured Patients with DADA2 : A commentary on "Hematopoietic cell transplantation cures adenosine deaminase 2 deficiency: report on 30 patients" by Hashem H et al.|2021|Yamashita M,Morio T,|

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452581
Journal of Clinical Immunology; Hashem H, Bucciol G et. al.

Jul 30th, 2021 - Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages)...

Two Cases Presenting With Unilateral Adduction Deficit Associated With Human Adenosine ...
https://doi.org/10.3928/01913913-20210416-02
Journal of Pediatric Ophthalmology and Strabismus; Veryser E, Meyts I et. al.

Jul 22nd, 2021 - Deficiency of human adenosine deaminase 2 (DADA2) is an auto-inflammatory inborn error of immunity caused by biallelic deleterious mutations in the gene encoding ADA2. The purpose of this article is to raise awareness among ophthalmologists and pe...

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