ALLMedicine™ Afibrinogenemia Center
Research & Reviews 60 results
Haematologica Guipponi M, Masclaux F et. al.
Jul 2nd, 2021 - Congenital afibrinogenemia is the most severe congenital fibrinogen disorder, characterised by undetectable fibrinogen in circulation. Causative mutations can be divided into two main classes: null mutations with no protein production at all and m...
Blood Coagulation & Fibrinolysis : an International Journ... Nojehdeh ST, Mojbafan M et. al.
Apr 27th, 2021 - Congenital afibrinogenemia is a rare autosomal recessive disorder that is caused by defects in the fibrinogen. Fibrinogen is a hexameric glycoprotein made of two pairs of three homologous polypeptide chains including Aα, Bβ, and γ that are encoded...
Blood Casini A, von Mackensen S et. al.
Jan 30th, 2021 - Due to its low prevalence, epidemiologic data on afibrinogenemia are limited and none are available on health-related quality of life (HRQoL). We conducted a cross-sectional international study to characterize the clinical features, the fibrinogen...
Thrombosis Research; Ross CR, Subramanian S et. al.
Jan 25th, 2021 - Congenital afibrinogenemia is a rare coagulation disorder resulting from a deficiency in fibrinogen. This study assessed the pharmacokinetics, surrogate efficacy and safety of FIB Grifols, a new human plasma-derived fibrinogen concentrate, to trea...
Blood Reviews; Casini A, Neerman-Arbez M et. al.
Jan 10th, 2021 - Fibrinogen is a complex protein playing a major role in coagulation. Congenital afibrinogenemia, characterized by the complete absence of fibrinogen, is associated with major hemostatic defects. Even though the clinical course is unpredictable and...