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About 188 results

ALLMedicine™ Afibrinogenemia Center

Research & Reviews  71 results

Impact of fibrinogen infusion on thrombin generation and fibrin clot structure in patie...
https://doi.org/10.1055/a-1745-0420
Thrombosis and Haemostasis; Djambas Khayat C, Marchi R et. al.

Jan 20th, 2022 - Inherited afibrinogenemia is a very rare disease characterized by complete absence of fibrinogen in the circulation and an increased risk in both thrombosis and bleeding. Infusion of fibrinogen concentrate (FC) is the main approach for prevention ...

Risk and Management of Intracerebral Hemorrhage in Patients with Bleeding Disorders.
https://doi.org/10.1055/s-0041-1740566
Seminars in Thrombosis and Hemostasis; Dorgalaleh A, Farshi Y et. al.

Jan 7th, 2022 - Intracerebral hemorrhage (ICH) is the most dreaded complication, and the main cause of death, in patients with congenital bleeding disorders. ICH can occur in all congenital bleeding disorders, ranging from mild, like some platelet function disord...

A homozygous duplication of the FGG exon 8-intron 8 junction causes congenital afibrino...
https://doi.org/10.3324/haematol.2021.278945
Haematologica Guipponi M, Masclaux F et. al.

Jul 2nd, 2021 - Congenital afibrinogenemia is the most severe congenital fibrinogen disorder, characterised by undetectable fibrinogen in circulation. Causative mutations can be divided into two main classes: null mutations with no protein production at all and m...

Identification of a novel mutation in congenital afibrinogenemia in Iranian patients.
https://doi.org/10.1097/MBC.0000000000001041
Blood Coagulation & Fibrinolysis : an International Journ... Nojehdeh ST, Mojbafan M et. al.

Apr 27th, 2021 - Congenital afibrinogenemia is a rare autosomal recessive disorder that is caused by defects in the fibrinogen. Fibrinogen is a hexameric glycoprotein made of two pairs of three homologous polypeptide chains including Aα, Bβ, and γ that are encoded...

Clinical phenotype, fibrinogen supplementation, and health-related quality of life in p...
https://doi.org/10.1182/blood.2020009472
Blood Casini A, von Mackensen S et. al.

Jan 30th, 2021 - Due to the low prevalence of afibrinogenemia, epidemiologic data on afibrinogenemia are limited, and no data are available on health-related quality of life (HRQoL). We conducted a cross-sectional international study to characterize the clinical f...

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Drugs  2 results see all →

Clinicaltrials.gov  2 results

Pharmacokinetics, Efficacy, and Safety of Human Plasma-Derived Fibrinogen (FIB Grifols) in Participants With Congenital Afibrinogenemia
https://clinicaltrials.gov/ct2/show/NCT02281500

Oct 29th, 2020 - This study is a phase I-II, multi-center, prospective, open-label, single-arm, clinical trial to evaluate Pharmacokinetic (PK), efficacy, and safety of human plasma-derived fibrinogen concentrate (FIB Grifols) in adult and pediatric participants w...

Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency
https://clinicaltrials.gov/ct2/show/NCT02065882

Jul 25th, 2019 - The present study is designed as a prospective, open-label, multicentre, phase I/III study investigating the 14 day single-dose pharmacokinetic properties, efficacy and safety of BT524 following intravenous administration in the treatment or proph...

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