ALLMedicine™ Alpha Thalassemia Center
Research & Reviews 85 results
https://doi.org/10.1371/journal.ppat.1010748
PLoS Pathogens; Stilp AC, Scherer M et. al.
Aug 9th, 2022 - The chromatin remodeling protein alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a component of promyelocytic leukemia nuclear bodies (PML-NBs) and thereby mediates intrinsic immunity against several viruses including human cytome...
https://clinicaltrials.gov/ct2/show/NCT02692872
Jul 19th, 2022 - Many of the complications of sickle cell disease, such as stroke, kidney damage, skin ulceration,pulmonary hypertension, and cardiac hypertrophy are prevented, delayed or reduced by inheritance of one of more deletions of the alpha globin genes. O...
https://clinicaltrials.gov/ct2/show/NCT02986698
Apr 25th, 2022 - Alpha thalassemia major (ATM) is almost universally fatal in utero and represents an orphan disease with an unmet need for effective therapies. The only current treatment to allow the fetus to be born is to perform in utero transfusions (IUT) of r...
https://doi.org/10.1080/17474086.2022.2040984
Expert Review of Hematology; Serjeant GR
Feb 11th, 2022 - The hematological and clinical features vary markedly between the different genotypes of sickle cell disease. Even within the single genotype of homozygous sickle cell disease (HbSS), there is marked variability that is presumed to result from int...
https://doi.org/10.1007/s00330-021-08444-1
European Radiology; Wu S, Zhang X et. al.
Feb 9th, 2022 - To construct a radiomics nomogram based on multiparametric MRI data for predicting isocitrate dehydrogenase 1 mutation (IDH +) and loss of nuclear alpha thalassemia/mental retardation syndrome X-linked expression (ATRX -) in patients with lower-gr...
Clinicaltrials.gov 7 results
https://clinicaltrials.gov/ct2/show/NCT02692872
Jul 19th, 2022 - Many of the complications of sickle cell disease, such as stroke, kidney damage, skin ulceration,pulmonary hypertension, and cardiac hypertrophy are prevented, delayed or reduced by inheritance of one of more deletions of the alpha globin genes. O...
https://clinicaltrials.gov/ct2/show/NCT02986698
Apr 25th, 2022 - Alpha thalassemia major (ATM) is almost universally fatal in utero and represents an orphan disease with an unmet need for effective therapies. The only current treatment to allow the fetus to be born is to perform in utero transfusions (IUT) of r...
https://clinicaltrials.gov/ct2/show/NCT04872179
Oct 4th, 2021 - The aim of this registry is to prospectively and retrospectively collect data on patients who are diagnosed with alpha thalassemia major and other alpha thalassemia mutations. Data collected will be used to: Identify patient outcomes of therapies....
https://clinicaltrials.gov/ct2/show/NCT03114137
May 25th, 2018 - Sickle cell disease (SCD), one of the lost common genetic diseases worldwide, is caused by a mutation in the β globin gene. Most patients with this disease are homozygous for the βS allele (SS), whereas others have inherited a βS allele with anoth...
https://clinicaltrials.gov/ct2/show/NCT00159029
Aug 10th, 2017 - Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates. We...
Patient Education 2 results
https://www.hopkinsmedicine.org/health/conditions-and-diseases/alpha-thalassemia
Thalassemia is an inherited blood disorder. It is passed down from one or both parents through their genes. There are two main types of thalassemia: alpha and beta. Different genes are affected for each type. Thalassemia can cause mild or severe a...
https://www.hopkinsmedicine.org/health/conditions-and-diseases/thalassemias
Detailed information on thalassemias, including alpha thalassemia, beta thalassemia (Cooley's anemia)