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About 235 results

ALLMedicine™ Alpha Thalassemia Center

Research & Reviews  85 results

The chromatin remodeling protein ATRX positively regulates IRF3-dependent type I interf...
https://doi.org/10.1371/journal.ppat.1010748
PLoS Pathogens; Stilp AC, Scherer M et. al.

Aug 9th, 2022 - The chromatin remodeling protein alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a component of promyelocytic leukemia nuclear bodies (PML-NBs) and thereby mediates intrinsic immunity against several viruses including human cytome...

Screening for Alpha Thalassemia in Healthy Volunteers
https://clinicaltrials.gov/ct2/show/NCT02692872

Jul 19th, 2022 - Many of the complications of sickle cell disease, such as stroke, kidney damage, skin ulceration,pulmonary hypertension, and cardiac hypertrophy are prevented, delayed or reduced by inheritance of one of more deletions of the alpha globin genes. O...

In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)
https://clinicaltrials.gov/ct2/show/NCT02986698

Apr 25th, 2022 - Alpha thalassemia major (ATM) is almost universally fatal in utero and represents an orphan disease with an unmet need for effective therapies. The only current treatment to allow the fetus to be born is to perform in utero transfusions (IUT) of r...

Phenotypic variation in sickle cell disease: the role of beta globin haplotype, alpha t...
https://doi.org/10.1080/17474086.2022.2040984
Expert Review of Hematology; Serjeant GR

Feb 11th, 2022 - The hematological and clinical features vary markedly between the different genotypes of sickle cell disease. Even within the single genotype of homozygous sickle cell disease (HbSS), there is marked variability that is presumed to result from int...

A nomogram strategy for identifying the subclassification of IDH mutation and ATRX expr...
https://doi.org/10.1007/s00330-021-08444-1
European Radiology; Wu S, Zhang X et. al.

Feb 9th, 2022 - To construct a radiomics nomogram based on multiparametric MRI data for predicting isocitrate dehydrogenase 1 mutation (IDH +) and loss of nuclear alpha thalassemia/mental retardation syndrome X-linked expression (ATRX -) in patients with lower-gr...

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Clinicaltrials.gov  7 results

Screening for Alpha Thalassemia in Healthy Volunteers
https://clinicaltrials.gov/ct2/show/NCT02692872

Jul 19th, 2022 - Many of the complications of sickle cell disease, such as stroke, kidney damage, skin ulceration,pulmonary hypertension, and cardiac hypertrophy are prevented, delayed or reduced by inheritance of one of more deletions of the alpha globin genes. O...

In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)
https://clinicaltrials.gov/ct2/show/NCT02986698

Apr 25th, 2022 - Alpha thalassemia major (ATM) is almost universally fatal in utero and represents an orphan disease with an unmet need for effective therapies. The only current treatment to allow the fetus to be born is to perform in utero transfusions (IUT) of r...

International Registry of Patients With Alpha Thalassemia
https://clinicaltrials.gov/ct2/show/NCT04872179

Oct 4th, 2021 - The aim of this registry is to prospectively and retrospectively collect data on patients who are diagnosed with alpha thalassemia major and other alpha thalassemia mutations. Data collected will be used to: Identify patient outcomes of therapies....

Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose
https://clinicaltrials.gov/ct2/show/NCT03114137

May 25th, 2018 - Sickle cell disease (SCD), one of the lost common genetic diseases worldwide, is caused by a mutation in the β globin gene. Most patients with this disease are homozygous for the βS allele (SS), whereas others have inherited a βS allele with anoth...

Genetics of Alpha Thalassemia in Israeli Ethnic Groups
https://clinicaltrials.gov/ct2/show/NCT00159029

Aug 10th, 2017 - Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates. We...

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Patient Education  2 results

Alpha Thalassemia
https://www.hopkinsmedicine.org/health/conditions-and-diseases/alpha-thalassemia

Thalassemia is an inherited blood disorder. It is passed down from one or both parents through their genes. There are two main types of thalassemia: alpha and beta. Different genes are affected for each type. Thalassemia can cause mild or severe a...

Thalassemias
https://www.hopkinsmedicine.org/health/conditions-and-diseases/thalassemias

Detailed information on thalassemias, including alpha thalassemia, beta thalassemia (Cooley's anemia)

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