About 2,768 results

ALLMedicine™ Aplastic Anemia Center

Research & Reviews  914 results

A comparative study of porcine antihuman lymphocyte globulin versus antithymocyte globu...
Hematology (Amsterdam, Netherlands); Zhang Y, Liu L et. al.

Sep 24th, 2021 - To compare the outcomes of antihuman T lymphocyte globulin (ATG-F) and porcine antihuman lymphocyte globulin (p-ALG) as part of a conditioning regimen in hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA). we performed...

Interlukin-27 rs153109 polymorphism confers the susceptibility and prognosis of aplasti...
International Journal of Laboratory Hematology; Yu W, Yang W

Sep 17th, 2021 - Accumulating evidence has indicated that interleukin (IL)-27 and its gene polymorphisms exert pivotal impact on several autoimmune disorders. This research intended to investigate the relationship between IL-27 rs153109 polymorphism with risk and ...

Long-term outcomes in severe aplastic anemia patients treated with immunosuppression an...
Blood Patel BA, Groarke EM et. al.

Sep 16th, 2021 - Patients with severe aplastic anemia (SAA) are either treated with bone marrow transplant (BMT) or immunosuppression (IST) depending on their age, comorbidities, and available donors. In 2017, our phase 2 trial reported improved hematologic respon...

Detection and treatment of cerebral toxoplasmosis in an aplastic pediatric post-allogen...
BMC Infectious Diseases; Brewer D, MacMillan ML et. al.

Sep 12th, 2021 - Cerebral toxoplasmosis infection presents with non-specific neurologic symptoms in immunocompromised patients. With lack of measurable adaptive immune responses and reluctance to sample affected brain tissue, expedient diagnosis to guide directed ...

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Guidelines  1 results

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellula...
Haematologica Bennett JM, Orazi A

Jan 16th, 2009 - Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three wo...

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Drugs  131 results see all →

Clinicaltrials.gov  2 results

Fludarabine-based Conditioning for Severe Aplastic Anemia (BMT CTN 0301)

Oct 27th, 2017 - BACKGROUND: Aplastic anemia (AA) remains a life-threatening illness. Treatment options include supportive care (transfusions, growth factors, etc.), immunosuppression therapy and stem cell transplantation. Only the latter two have favorably impact...

Multicenter Transplant Study for Fanconi Anemia

Jun 29th, 2016 - The trial proposed is a single arm phase II multicenter treatment protocol designed to examine engraftment, toxicity, graft-versus-host disease, and ultimate disease-free survival following a novel cytoreductive regimen including busulfan, cycloph...

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News  56 results

Chimerism and the use of fludarabine associated with secondary graft failure in aplastic anemia
Mark S. Lesney

Mar 6th, 2020 - Inferior overall survival was observed in patients with aplastic anemia who had mixed or complete recipient-type chimerism or complete donor chimerism after hematopoietic stem cell transplantation (HSCT), according to the results of a registry dat.

Aplastic Anemia: Diagnosis and Treatment

Oct 7th, 2019 - Treatment of Acquired Aplastic Anemia Supportive Care While the workup and treatment plan are being established, attention should be directed at supportive care for prevention of complications. The most common complications leading to death in pat.

Combination Immunotherapy Leading to Severe Hepatotoxicity and Fatal Aplastic Anemia: Case Report and Review of the Literature
Dominick A, Fields-Meehan JE et. al.

Sep 5th, 2019 - Background: Dual immune checkpoint blockade (DICB) is utilized for a variety of malignancies. These therapies have a unique and often unpredictable side effect profile compared to conventional chemotherapy.

Aplastic Anemia: Current Treatment

Jan 23rd, 2019 - Immunosuppressive Therapy For patients without an HLA-matched sibling donor or those who are older than 50 years of age, immunosuppressive therapy is the first-line therapy. ATG and cyclosporine A are the treatments of choice.

Aplastic Anemia: Evaluation and Diagnosis

Jan 18th, 2019 - In addition to peripheral blood findings, bone marrow biopsy is essential for the diagnosis, and should demonstrate a markedly hypocellular marrow (cellularity < 25%), occasionally with an increase in T lymphocytes. 7,39 Because marrow cellularity.

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Patient Education  3 results see all →