About 293 results

ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center

Research & Reviews  115 results

Presentation and diagnosis of autoimmune lymphoproliferative syndrome (ALPS).
Expert Review of Clinical Immunology; Lambert MP

Sep 11th, 2021 - Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of immune dysregulation characterized by derangements in first apoptosis signal (FAS) mediated apoptosis and elevations in CD3+TCRαβ+CD4-CD8- "double negative" T (DNT) cells. As our...

Variants in CASP10, a diagnostic challenge: Single center experience and review of the ...
Clinical Immunology (Orlando, Fla.); Matas Pérez E, Valdivieso Shephard JL et. al.

Jul 31st, 2021 - Autoimmune lymphoproliferative syndrome is a primary immunodeficiency caused by variants in FAS-mediated apoptosis related genes and is characterized by lymphadenopathy, splenomegaly and autoimmunity. A total of six different variants in CASP10 ha...

Sirolimus is effective in autoimmune lymphoproliferative syndrome-type III: A pedigree ...
International Journal of Immunopathology and Pharmacology; Gu H, Chen Z et. al.

Jul 1st, 2021 - Autoimmune lymphoproliferative syndrome (ALPS) usually presents in childhood with fever, nonmalignant splenomegaly, and lymphadenopathy along with cytopenia, which is caused by mutations in the FAS apoptotic pathway. The TCRαβ + CD4/CD8 double-neg...

Genetic characterization of short stature patients with overlapping features of growth ...
The Journal of Clinical Endocrinology and Metabolism; Andrews A, Maharaj A et. al.

Jun 18th, 2021 - Growth hormone insensitivity (GHI) in children is characterized by short stature, functional IGF-I deficiency and normal or elevated serum GH concentrations. The clinical and genetic etiology of GHI is expanding. We undertook genetic characterizat...

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Guidelines  1 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
Blood Oliveira JB, Bleesing JJ et. al.

Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

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News  1 results

Immunosuppressant can treat autoimmune cytopenias
HT Staff

Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.

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