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About 393 results

ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center

Research & Reviews  144 results

Study of Autoimmune Lymphoproliferative Syndrome (ALPS)
https://clinicaltrials.gov/ct2/show/NCT00001350

Jun 24th, 2022 - The purpose of this family based natural history protocol is to allow for patients, and relatives of patients to be screened for Autoimmune Lymphoproliferative Syndrome (ALPS) and related disorders of apoptosis, Ras Associated Leukoproliferative D...

The Contribution of Rare Copy Number Variants in FAS Towards Pathogenesis of Autoimmune...
https://doi.org/10.1182/bloodadvances.2021005835
Blood Advances; Jevtich KC, Price S et. al.

Apr 28th, 2022 - Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic nonmalignant lymphadenopathy, splenomegaly, cytopenias, and other autoimmune manifestations. ALPS is caused by lymphocyte accumulation due to defects in FAS-mediated apopto...

A unique phenotype of longitudinal extensive transverse myelitis in autoimmune lymphopr...
https://doi.org/10.1016/j.jneuroim.2022.577866
Journal of Neuroimmunology; Dekeyser C, Naesens L et. al.

Apr 23rd, 2022 - A 49-year-old patient with a history of lymphoproliferation and autoimmune cytopenias presented with unexplained longitudinal extensive transverse myelitis. Flow cytometry on peripheral blood showed an elevated level of double negative T lymphocyt...

Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoi...
https://doi.org/10.1002/eji.202149529
European Journal of Immunology; Minguet S, Nyström A et. al.

Apr 21st, 2022 - B-cell tolerance to self-antigen is an active process that requires the temporal and spatial integration of signals of defined intensity. In common variable immune deficiency disorders, CTLA-4 deficiency, autoimmune lymphoproliferative syndrome, o...

ALPS, FAS, and beyond: from inborn errors of immunity to acquired immunodeficiencies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810460
Annals of Hematology; Consonni F, Gambineri E et. al.

Jan 22nd, 2022 - Autoimmune lymphoproliferative syndrome (ALPS) is a primary immune regulatory disorder characterized by benign or malignant lymphoproliferation and autoimmunity. Classically, ALPS is due to mutations in FAS and other related genes; however, recent...

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Guidelines  1 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953894
Blood Oliveira JB, Bleesing JJ et. al.

Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

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Clinicaltrials.gov  11 results

Study of Autoimmune Lymphoproliferative Syndrome (ALPS)
https://clinicaltrials.gov/ct2/show/NCT00001350

Jun 24th, 2022 - The purpose of this family based natural history protocol is to allow for patients, and relatives of patients to be screened for Autoimmune Lymphoproliferative Syndrome (ALPS) and related disorders of apoptosis, Ras Associated Leukoproliferative D...

Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA
https://clinicaltrials.gov/ct2/show/NCT04470804

Jul 7th, 2021 - Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. ...

Sirolimus Treatment for Refractory PRCA
https://clinicaltrials.gov/ct2/show/NCT03364764

Jul 6th, 2021 - Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. ...

Expression of CD19 Complex in Lymphoproliferative Disorders
https://clinicaltrials.gov/ct2/show/NCT04734470

Feb 4th, 2021 - Lymphoproliferative disorders (LPD)comprise a heterogeneous group of diseases characterized by uncontrolled production of lymphocytes that cause monoclonal lymphocytosis, lymphadenopathy and bone marrow infiltration.They Typically occur in people ...

Fluorodeoxyglucose Imaging Studies to Detect Lymphoma
https://clinicaltrials.gov/ct2/show/NCT01672918

Dec 5th, 2019 - The Autoimmune Lymphoproliferative Syndrome (ALPS) is an inherited disorder associated with defective lymphocyte apoptosis, which is clinically characterized by prominent nonmalignant lymphadenopathy, hepatosplenomegaly, and overt autoimmune disea...

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News  1 results

Immunosuppressant can treat autoimmune cytopenias
https://www.mdedge.com/hematology-oncology/article/187516/anemia/immunosuppressant-can-treat-autoimmune-cytopenias
HT Staff

Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.

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