ALLMedicine™ Castleman Disease Center

May 12th, 2022 - Castleman disease (CD) is a lymphoproliferative disorder that rarely occurs in the pancreas. We reported a 46-year-old man was admitted to our hospital due to recurrent minor epigastric pain for 7 days. The abdominal enhanced CT showed irregular f...

May 5th, 2022 - Castleman disease (CD) describes a group of rare, potentially fatal lymphoproliferative disorders. To determine factors associated with mortality in CD, we analysed data from deceased patients in the ACCELERATE registry and compared them with matc...

Apr 22nd, 2022 - Human herpesvirus(HHV)-8-negative, idiopathic multicentric Castleman disease (iMCD) is a rare hematologic illness. Current therapeutic options are limited and provide benefit for only a subset of patients. Blockade of IL-6 signaling with siltuxima...

Apr 9th, 2022 - When idiopathic retroperitoneal fibrosis mimics Castleman disease: a challenging differential diagnosis.|2022|Covelli C,Carosi I,Graziano P,Ascani S,|diagnosis,diagnostic imaging,

Mar 31st, 2022 - While infection should always lead the differential when a patient with AIDS presents with fever, inflammatory and malignant aetiologies should also be considered. With profound immunocompromise, malignancies can develop as sequelae of viral oncog...

Apr 22nd, 2022 - Human herpesvirus(HHV)-8-negative, idiopathic multicentric Castleman disease (iMCD) is a rare hematologic illness. Current therapeutic options are limited and provide benefit for only a subset of patients. Blockade of IL-6 signaling with siltuxima...

Jan 3rd, 2022 - The study team will examine genetic changes, also known as mutations, in the DNA of participants' blood, or if applicable, bone marrow specimen. These types of tests are increasingly used by doctors to improve the accuracy of diagnosis and make de...

Aug 24th, 2021 - This project is supported by the Castleman Disease Collaborative Network. Visit the CDCN website at http://www.cdcn.org/accelerate to sign up for the ACCELERATE registry! The ACCELERATE patient registry will give patients and families the opportun...

Oct 27th, 2020 - BACKGROUND: Kaposi sarcoma herpesvirus-associated multicentric Castleman disease (KSHVMCD) is a rare lymphoproliferative disorder that develops predominantly in human immunodeficiency deficiency virus (HIV) infected patients. Patients often have s...

Jul 31st, 2018 - The CDCN proposes to establish a biobank and associated clinical data for Castleman disease. Tissue and fluid (blood and saliva) samples will be collected both prospectively and retrospectively. Blood or saliva samples may also be collected from r...

Mar 12th, 2021 - Liposomal doxorubicin (Dox) plus pomalidomide (Pom) was safe and active in heavily pretreated patients with Kaposi sarcoma, according to results from a phase 1/2 trial. Dr.

Feb 5th, 2021 - In response to the novel coronavirus disease 2019 (COVID-19) pandemic, investigators around the world channeled their efforts into acquiring a better understanding of the virus so that they could rapidly identify any weapons that may be used in th...

Oct 10th, 2018 - Photo from Penn Medicine David C. Fajgenbaum, MD The anti-IL-6 antibody siltuximab is central to first-line treatment of idiopathic multicentric Castleman disease (iMCD), according to new guidelines on iMCD published in Blood.

Sep 28th, 2018 - The anti-interleukin-6 antibody siltuximab is central to first-line treatment of idiopathic multicentric Castleman disease (MCD), although adjuvant chemotherapy can be critical in severe cases, according to the first-ever consensus treatment guide.

Oct 6th, 2017 - A rare type of mantle cell lymphoma (MCL) has features that are similar to those of Castleman disease, according to a recent report based on three patient cases. Lymph node biopsies for these patients initially indicated histologic features consis.