ALLMedicine™ Hypofibrinogenemia Center

Jun 23rd, 2022 - The surgical procedure to separate conjoined twins represents a rare and major challenge. One of the most feared perioperative scenarios is the presence of coagulopathy secondary to bleeding. We present a case of the surgical separation of ischiop...

Jun 2nd, 2022 - This study was conducted to evaluate clinical outcomes after fibrinogen administration in hypofibrinogenemia following severe traumatic brain injury. Post traumatic coagulopathy (PTC) is a common but devastating medical condition in patients with ...

May 9th, 2022 - Study process is as follows. Informed consent for subjects fulfilling the inclusion criteria. Laboratory evaluation will be done for subjects according to the following diagnostic criteria. Diagnosis will be established if one of either 1 or 2 bel...

May 5th, 2022 - Thrombin time is a screening coagulation test designed to assess fibrin formation from fibrinogen in plasma. The reference range for the thrombin time is usually less than 20 seconds (ie, 15-19 seconds), but this depends on the test kit/instrument...

May 5th, 2022 - Reference Range Thrombin time is a screening coagulation test designed to assess fibrin formation from fibrinogen in plasma. The reference range for the thrombin time is usually less than 20 seconds (ie, 15-19 seconds), but this depends on the tes...

May 9th, 2022 - Study process is as follows. Informed consent for subjects fulfilling the inclusion criteria. Laboratory evaluation will be done for subjects according to the following diagnostic criteria. Diagnosis will be established if one of either 1 or 2 bel...

Mar 29th, 2022 - Intravenous recombinant tissue plasminogen activator (rtPA) is the first recommended reperfusion therapy for acute ischemic stroke, as well as endovascular treatment in case of large vessel occlusion, but it increases the risk of ICH. The pathophy...

Feb 17th, 2022 - There is a need to increase the body of data on treatment effectiveness and safety in the ultra-rare setting of congenital fibrinogen deficiency. Real-world evidence (RWE) derived from non-interventional studies can describe product utilization, d...

Jan 11th, 2022 - This study will be a randomized (1:1; PCC vs. plasma), open-label trial of hemostatic therapies during heart transplantation. The goal is to enroll 60 patients. Informed consent will be obtained from patients meeting the inclusion and exclusion cr...

Oct 28th, 2021 - Once the need for fibrinogen supplementation is confirmed, study participants will be randomized into one of two treatment groups (n=15 in each group): Cryoprecipitate group (dose: 10 ml/kg; active control group) or Fibrinogen Concentrate group (d...

Jun 16th, 2020 - Figure 1. Hemophagocytosis in the bone marrow. The diagnosis of HLH is based on clinical criteria. Diagnostic criteria that were developed by the Histiocyte Society for HLH (HLH-2004 criteria) are the most commonly used. They include: Fever: ≥ 7 d...

Apr 19th, 2020 - Early reports on the COVID-19 pandemic allude to a cytokine storm or hyper-inflammation, especially in patients who succumbed to the illness. These conclusions are based on elevated levels of ferritin and other inflammatory markers, drawing compar...

Oct 25th, 2019 - SAN ANTONIO – Fibrinogen concentrate was noninferior to cryoprecipitate for controlling bleeding following cardiac surgery in the randomized FIBRES trial, Canadian investigators reported. Neil Osterweil/MDedge News Dr.