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ALLMedicine™ Large Granular Lymphocyte Leukemia Center

Research & Reviews  77 results

Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte Leukemia
https://clinicaltrials.gov/ct2/show/NCT00345345

May 3rd, 2022 - T Cell Large Granular Lymphocyte (T-LGL) lymphoproliferative disorders are a heterogeneous group of uncommon diseases which may involve a monoclonal or oligoclonal T cell population, which bear characteristic surface markers corresponding to activ...

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukem...
https://doi.org/10.1038/s41467-022-29175-x
Nature Communications; Gao S, Wu Z et. al.

Apr 13th, 2022 - T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease and bone marrow failure syndrome which responds to immunosuppressive therapies. We show single-cell TCR coupled with RNA sequencing of CD3+ T cells from 13 patient...

Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873566
Blood Cancer Journal; Bhattacharya D, Teramo A et. al.

Feb 26th, 2022 - CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown etiology. In this study, we molecularly characterized a cohort of patients (n = 35) by studying their T-cell receptor (TCR) repertoire and the presenc...

Genomic Landscape of TCR Alpha-Beta and TCR Gamma-Delta T-Large Granular Lymphocyte Leu...
https://doi.org/10.1182/blood.2021013164
Blood Cheon H, Xing JC et. al.

Jan 12th, 2022 - Large granular lymphocyte (LGL) leukemia comprises a group of rare lymphoproliferative disorders whose molecular landscape is incompletely defined. We leveraged paired whole exome and transcriptome sequencing in the largest LGL leukemia cohort to ...

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Clinicaltrials.gov  3 results

Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte Leukemia
https://clinicaltrials.gov/ct2/show/NCT00345345

May 3rd, 2022 - T Cell Large Granular Lymphocyte (T-LGL) lymphoproliferative disorders are a heterogeneous group of uncommon diseases which may involve a monoclonal or oligoclonal T cell population, which bear characteristic surface markers corresponding to activ...

Hu-Mik-beta1 to Treat T-Cell Large Granular Lymphocytic Leukemia
https://clinicaltrials.gov/ct2/show/NCT00076180

Jan 11th, 2019 - Background: T cell large granular lymphocyte (T-LGL) leukemia is a chronic lymphoproliferative disorder associated with granulocytopenia, anemia and/or thrombocytopenia. Although agents such as cyclosporine and methotrexate have shown activity in ...

Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia
https://clinicaltrials.gov/ct2/show/NCT00363779

Jul 21st, 2015 - Background: LGL leukemia is a low grade non-Hodgkins Lymphoma characterized by tissue invasion of the marrow, spleen and liver Recurrent infections due to chronic neutropenia and transfusion-dependent anemia are the principal causes for initiation...

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