ALLMedicine™ Large Granular Lymphocyte Leukemia Center
Research & Reviews 77 results
https://clinicaltrials.gov/ct2/show/NCT00345345
May 3rd, 2022 - T Cell Large Granular Lymphocyte (T-LGL) lymphoproliferative disorders are a heterogeneous group of uncommon diseases which may involve a monoclonal or oligoclonal T cell population, which bear characteristic surface markers corresponding to activ...
https://doi.org/10.1007/s00277-022-04847-2 10.1182/blood-2016-05-717140 10.1182/blood.V87.7.3000.bloodjournal8773000 10.1111/j.1365-2141.2006.06295.x 10.1182/blood.v97.12.3995 10.1111/j.1365-2141.2009.08027.x 10.3324/haematol.2009.013557 10.1177/0961203311411349 10.1038/leu.2010.278 10.3324/haematol.11192 10.1007/s12185-018-2446-y 10.3324/haematol.11655 10.1182/blood-2016-08-692590 10.1182/blood.2021010898 10.1111/bjh.13376 10.1111/j.1600-0609.2009.01213.x 10.1007/s00277-009-0895-3 10.1186/1756-8722-6-82 10.1016/j.blre.2006.01.003 10.1007/s00277-020-03926-6 10.1002/ajh.26183 10.3324/haematol.12871 10.1111/cas.12341 10.1007/s12185-021-03100-2 10.1111/bjh.15245
Annals of Hematology; Wu X, Cheng L et. al.
Apr 24th, 2022 - Adult pure red cell aplasia (PRCA) is a rare syndrome characterized by a severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from bone marrow. The standard treatment has not yet been established for PRCA, although cyclosporin...
https://doi.org/10.1038/s41467-022-29175-x
Nature Communications; Gao S, Wu Z et. al.
Apr 13th, 2022 - T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease and bone marrow failure syndrome which responds to immunosuppressive therapies. We show single-cell TCR coupled with RNA sequencing of CD3+ T cells from 13 patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873566
Blood Cancer Journal; Bhattacharya D, Teramo A et. al.
Feb 26th, 2022 - CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown etiology. In this study, we molecularly characterized a cohort of patients (n = 35) by studying their T-cell receptor (TCR) repertoire and the presenc...
https://doi.org/10.1182/blood.2021013164
Blood Cheon H, Xing JC et. al.
Jan 12th, 2022 - Large granular lymphocyte (LGL) leukemia comprises a group of rare lymphoproliferative disorders whose molecular landscape is incompletely defined. We leveraged paired whole exome and transcriptome sequencing in the largest LGL leukemia cohort to ...
Clinicaltrials.gov 3 results
https://clinicaltrials.gov/ct2/show/NCT00345345
May 3rd, 2022 - T Cell Large Granular Lymphocyte (T-LGL) lymphoproliferative disorders are a heterogeneous group of uncommon diseases which may involve a monoclonal or oligoclonal T cell population, which bear characteristic surface markers corresponding to activ...
https://clinicaltrials.gov/ct2/show/NCT00076180
Jan 11th, 2019 - Background: T cell large granular lymphocyte (T-LGL) leukemia is a chronic lymphoproliferative disorder associated with granulocytopenia, anemia and/or thrombocytopenia. Although agents such as cyclosporine and methotrexate have shown activity in ...
https://clinicaltrials.gov/ct2/show/NCT00363779
Jul 21st, 2015 - Background: LGL leukemia is a low grade non-Hodgkins Lymphoma characterized by tissue invasion of the marrow, spleen and liver Recurrent infections due to chronic neutropenia and transfusion-dependent anemia are the principal causes for initiation...
