ALLMedicine™ Sickle Cell Anemia Center

May 14th, 2022 - Pharmacogenomics of hydroxyurea therapy and fetal hemoglobin (HbF) levels in sickle cell anemia.|2022|Sales RR,Nogueira BL,Luizon MR,|

May 13th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

May 13th, 2022 - Individuals with sickle cell anemia have heightened risk of stroke and cognitive dysfunction. Given its high prevalence globally, whether sickle cell trait (SCT) is a risk factor for neurological injury has been of interest; however, data have bee...

May 4th, 2022 - This is a case report about a 7-year-old male child with sickle cell anemia (S/β+) who died unexpectedly during hospitalization, justifying the performance of a forensic autopsy completed by histological examination of organ fragments and toxicolo...

Apr 16th, 2022 - Acute changes in cardiopulmonary hemodynamics that include tricuspid-regurgitant-jet-velocity elevation measured by Doppler-echocardiography are often encountered during sickle cell vaso-occlusive pain and acute chest syndrome. Arginine and nitric...

Jun 19th, 2013 - This aim of this statement is to report an expert consensus on the diagnosis and treatment of cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover other hemoglobinopathies, including thalassemia intermedia and s...

May 13th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Apr 12th, 2022 - 200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, t...

Mar 4th, 2022 - This is an open-label extension study of IMR-687 in adult patients with SCA who were previously participants in the Phase 2a study titled "A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study of IMR-687 in Adult Patients with Sickle Cell...

Jan 3rd, 2022 - As the transporter responsible for basal levels of glucose flux, Glucose transporter 1 (GLUT1) is expressed at low levels in most tissues. In contrast, GLUT1 is very highly expressed on human erythrocytes. Human erythrocytes possess up to 5x105 co...

Dec 1st, 2021 - The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia. Although HU is used to tre...

Sep 16th, 2021 - Prolonged treatment with hydroxyurea may improve -- and possibly even reverse -- cardiac complications in pediatric patients with sickle cell anemia, a retrospective study found. Those on hydroxyurea for less than 1 year had a significantly greate...

Jul 21st, 2021 - Sickle cell disease (SCD) was associated with a significantly increased risk of COVID-19-related hospitalization and death in adults, U.K. researchers found. Their cohort study showed that having SCD quadrupled a person's risk for COVID-19-related...

Apr 2nd, 2021 - Transfusion is 1 of 2 disease-modifying therapies for adults with sickle cell anemia, the other being hydroxyurea, explains Morey Blinder, MD. There are several indications for transfusion in patients with sickle cell disease, with the best studie...

Dec 9th, 2020 - The cognitive and emotional status of children with sickle cell disease (SCD) appears to have a significant effect on how they cope with pain and use health care resources, investigators have found. Results of a retrospective study of 112 children.

Dec 5th, 2020 - It seems the older I get, the more frequently high school students, undergraduates, medical students, or residents drop by my office to talk about career choices, inquire about shadowing, or request an interview for a school project. Tell me about...