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About 2,240 results

ALLMedicine™ Von Willebrand Disease Center

Research & Reviews  804 results

Postpartum hemorrhage in women with von Willebrand disease: Consider other etiologies.
https://doi.org/10.1016/j.jogc.2022.03.017
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Kazi S, Arusi I et. al.

May 16th, 2022 - Higher rates of postpartum hemorrhage (PPH) have been reported for women with von Willebrand disease (VWD). Comprehensive multidisciplinary care reduces these rates; thus PPH may not be secondary to VWD. We conducted a retrospective review for the...

Efficacy and safety of von Willebrand factor concentrate almost devoid of factor VIII (...
https://doi.org/10.2450/2022.0329-21
Blood Transfusion = Trasfusione Del Sangue; Gouider E, Klukowska A et. al.

May 12th, 2022 - Plasma-derived von Willebrand factor (VWF) (Wilfactin®, LFB, France) was developed for prophylaxis and treatment of haemorrhages in both adults and adolescents with von Willebrand disease (VWD). Replacement therapy in paediatric patients is a key ...

Use of the von Willebrand factor concentrate with low factor VIII content to manage pat...
https://doi.org/10.1111/ejh.13785
European Journal of Haematology; Castaman G, Borchiellini A et. al.

May 10th, 2022 - The present review aims to summarize the state-of-the-art VWD treatment focusing on specific clinical settings (obstetrics, surgery, long-term prophylaxis and comorbidities) as well as on the use of a VWF concentrate with low FVIII content. Litera...

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
https://clinicaltrials.gov/ct2/show/NCT04398628

May 10th, 2022 - This is a longitudinal, natural history observational cohort study being conducted at approximately 150 ATHN-affiliated sites. Participants will be followed for a minimum of 15 years. Harmonized data elements will be collected at time of enrollmen...

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Guidelines  4 results

No. 163-Gynaecological and Obstetric Management of Women With Inherited Bleeding Disord...
https://doi.org/10.1016/j.jogc.2017.11.036
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Demers C, Derzko C et. al.

Feb 16th, 2018 - The prevalence of bleeding disorders, notably von Willebrand disease (vWD), among adult women with objectively documented menorrhagia is consistently reported to be 10% to 20% and is even higher in adolescents presenting with menorrhagia. Diagnost...

Evidence-based recommendations on the treatment of von Willebrand disease in Italy.
https://doi.org/10.2450/2008.0052-08
Blood Transfusion = Trasfusione Del Sangue; Mannucci PM, Franchini M et. al.

Jun 9th, 2009 - von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissu...

Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHL...
https://doi.org/10.1002/ajh.21405
American Journal of Hematology; Nichols WL, Rick ME et. al.

May 6th, 2009 - Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), t...

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the N...
https://doi.org/10.1111/j.1365-2516.2007.01643.x
Haemophilia : the Official Journal of the World Federatio... Nichols WL, Hultin MB et. al.

Mar 5th, 2008 - von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder affecting both males and females, causing mucous membrane and skin bleeding symptoms, and bleeding with surgical or other haemostatic challenges. VWD may be disprop...

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Drugs  19 results see all →

Clinicaltrials.gov  29 results

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
https://clinicaltrials.gov/ct2/show/NCT04398628

May 10th, 2022 - This is a longitudinal, natural history observational cohort study being conducted at approximately 150 ATHN-affiliated sites. Participants will be followed for a minimum of 15 years. Harmonized data elements will be collected at time of enrollmen...

Minimize Menorrhagia in Women With Von Willebrand Disease
https://clinicaltrials.gov/ct2/show/NCT02606045

Mar 2nd, 2022 - In this study, women age 13-45 years with mild to moderate VWD and menorrhagia will be enrolled at their hemophilia treatment centers (HTCs) and provide information on menstrual bleeding from their two past monthly cycles to establish baseline ble...

Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease VWD) Patients <6 Years of Age
https://clinicaltrials.gov/ct2/show/NCT04953884

Feb 21st, 2022 - The WIL-33 study aims to determine the efficacy, pharmacokinetics, immunogenicity and safety of wilate as routine prophylaxis in up to 12 paediatric patients (eight evaluable) with severe von Willebrand Disease VWD (defined as screening von Willeb...

rVWF IN PROPHYLAXIS
https://clinicaltrials.gov/ct2/show/NCT02973087

Aug 6th, 2021 - The purpose of this phase 3 study is to investigate the efficacy and safety, including immunogenicity, thrombogenicity and hypersensitivity reactions, as well as pharmacokinetics (PK), health related quality of life (HRQoL) and pharmacoeconomics o...

Recombinant Von Willebrand Factor in Subjects With Severe Von Willebrand Disease Undergoing Surgery
https://clinicaltrials.gov/ct2/show/NCT02283268

May 19th, 2021 - The purpose of the study is to assess the efficacy and safety of recombinant von Willebrand factor (rVWF) with or without ADVATE in major and minor elective surgical procedures in adult patients with hereditary severe von Willebrand disease (VWD).

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News  35 results

Type 3 von Willebrand a rare but serious bleeding disorder
https://www.mdedge.com/hematology-oncology/article/236987/bleeding-disorders/type-3-von-willebrand-rare-serious-bleeding
Neil Osterweil

Mar 10th, 2021 - Type 3 von Willebrand disease (VWD) is rare, but this form of the disease is associated with severe bleeding, particularly in muscles and joints, a bleeding disorders expert said. “There’s a virtually complete deficiency in von Willebrand factor [.

Von Willebrand disease guidelines address women’s bleeding concerns
https://www.mdedge.com/hematology-oncology/article/234756/bleeding-disorders/von-willebrand-disease-guidelines-address
Neil Osterweil

Jan 19th, 2021 - New guidelines issued jointly by four major international hematology groups focus on the management of patients with von Willebrand disease (VWD), the most common bleeding disorder in the world. The evidence-based guidelines, published in Blood Ad.

Labor outcomes unchanged by alternate anesthesia in bleeding disorder patients
https://www.mdedge.com/obgyn/article/204480/bleeding-disorders/labor-outcomes-unchanged-alternate-anesthesia-bleeding?channel=27970
Caleb Rans

Jul 11th, 2019 - Among pregnant women with inherited bleeding disorders, having a contraindication to regional anesthesia appears not to impact labor outcomes, according to a retrospective analysis. oceandigital/Thinkstock “The purpose of this study was to determi.

Fast Five Quiz: Bleeding Disorders
https://reference.medscape.com/viewarticle/915458

Jul 11th, 2019 - Bleeding disorders are conditions in which an individual's blood does not properly clot. Although hemophilia is perhaps the most well-known bleeding disorder, it is somewhat rare. Although it is typically less severe than other similar conditions,...

Fast Five Quiz: Bleeding Disorders
https://reference.medscape.com/viewarticle/915458_1

Jul 11th, 2019 - Bleeding disorders are conditions in which an individual's blood does not properly clot. Although hemophilia is perhaps the most well-known bleeding disorder, it is somewhat rare. Although it is typically less severe than other similar conditions,...

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Patient Education  5 results see all →