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ALLMedicine™ Alport Syndrome Center

Research & Reviews  711 results

Clinical and Genetic Features of Autosomal Dominant Alport Syndrome: A Case Series.
https://doi.org/10.1053/j.ajkd.2021.02.326
American Journal of Kidney Diseases : the Official Journa... Furlano M, Martínez V et. al.

Apr 10th, 2021 - Alport syndrome (AS) is a common genetic kidney disease accounting for approximately 2% of patients receiving kidney replacement therapy (KRT). It is caused by pathogenic variants in COL4A3, COL4A4 or COL4A5 genes. The aim of this study was to eva...

Study Design and Baseline Characteristics of the CARDINAL Trial: A Phase 3 Study of Bar...
https://doi.org/10.1159/000513777
American Journal of Nephrology; Chertow GM, Appel GB et. al.

Mar 31st, 2021 - Alport syndrome is a rare genetic disorder that affects as many as 60,000 persons in the USA and a total of 103,000 persons (<5 per 10,000) in the European Union [1, 2]. It is the second most common inherited cause of kidney failure and is charact...

The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971217
Renal Failure; Sannomiya Y, Kaseda S et. al.

Mar 12th, 2021 - Alport syndrome (AS) is a hereditary glomerular nephritis caused by mutation in one of the type IV collagen genes α3/α4/α5 that encode the heterotrimer COL4A3/4/5. Failure to form a heterotrimer due to mutation leads to the dysfunction of the glom...

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Guidelines  1 results

Clinical practice recommendations for the treatment of Alport syndrome: a statement of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505543
Pediatric Nephrology (Berlin, Germany); Kashtan CE, Ding J et. al.

Mar 30th, 2012 - We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of ...

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Clinicaltrials.gov  713 results

Clinical and Genetic Features of Autosomal Dominant Alport Syndrome: A Case Series.
https://doi.org/10.1053/j.ajkd.2021.02.326
American Journal of Kidney Diseases : the Official Journa... Furlano M, Martínez V et. al.

Apr 10th, 2021 - Alport syndrome (AS) is a common genetic kidney disease accounting for approximately 2% of patients receiving kidney replacement therapy (KRT). It is caused by pathogenic variants in COL4A3, COL4A4 or COL4A5 genes. The aim of this study was to eva...

Study Design and Baseline Characteristics of the CARDINAL Trial: A Phase 3 Study of Bar...
https://doi.org/10.1159/000513777
American Journal of Nephrology; Chertow GM, Appel GB et. al.

Mar 31st, 2021 - Alport syndrome is a rare genetic disorder that affects as many as 60,000 persons in the USA and a total of 103,000 persons (<5 per 10,000) in the European Union [1, 2]. It is the second most common inherited cause of kidney failure and is charact...

The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971217
Renal Failure; Sannomiya Y, Kaseda S et. al.

Mar 12th, 2021 - Alport syndrome (AS) is a hereditary glomerular nephritis caused by mutation in one of the type IV collagen genes α3/α4/α5 that encode the heterotrimer COL4A3/4/5. Failure to form a heterotrimer due to mutation leads to the dysfunction of the glom...

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News  5 results

Alport Syndrome Research Funding Is Awarded
https://www.mdedge.com/pediatrics/article/148143/rare-diseases/alport-syndrome-research-funding-awarded

Sep 27th, 2017 - Researchers at the University of Miami in Florida and University of Cyprus have each been awarded $100,000 to explore two drug repurposing projects to identify possible treatments for Alport syndrome. The funding was provided by the Alport Syndrom.

Marijuana and Transplants: A Catch-22 (CNN)
https://www.medpagetoday.com/transplantation/transplantation/64660

Apr 19th, 2017 - Use of medical marijuana may disqualify candidates for organ transplant, as a Maine man learned the hard way, according to CNN. Awaiting a kidney transplant in 2010, Garry Godfrey learned he had been dropped from the wait list because of his presc...

Alport Syndrome Foundation Announces Research Funding
https://www.mdedge.com/clinicianreviews/article/131705/rare-diseases/alport-syndrome-foundation-announces-research-funding

Feb 17th, 2017 - The Alport Syndrome Foundation has announced the availability of funding for research to find novel treatments to prevent kidney failure and hearing loss in all patients with Alport syndrome. Two $100,000 projects are anticipated.

Foundations Award Funding for Study of Alport Syndrome
https://www.mdedge.com/familymedicine/article/101707/foundations-award-funding-study-alport-syndrome
Cardiology News;

Aug 5th, 2015 - The Alport Syndrome Foundation (ASF), Pedersen Family Foundation, and Kidney Foundation of Canada have awarded two research grants for the study of Alport syndrome, a rare genetic kidney disease. The recipients are James Scholey, MD, of the Univer.

Research supports treatment for Alport syndrome
https://www.mdedge.com/pediatrics/article/98611/rare-diseases/research-supports-treatment-alport-syndrome

Apr 8th, 2015 - Until recently, most physicians thought of Alport syndrome as an untreatable disease. However, experiments carried out in mice with Alport syndrome showed that several different kinds of medication could slow loss of kidney function.

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