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ALLMedicine™ Acquired Generalized Lipodystrophy Center

Research & Reviews  20 results

Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904732
Nature Communications; Ziegler JF, Böttcher C et. al.

Dec 12th, 2019 - Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn's disease remains sparse. We here describe a patient with the unique combination of acquired ge...

Acquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes.
https://doi.org/10.2337/dc18-2535
Diabetes Care; Jehl A, Cugnet-Anceau C et. al.

Aug 23rd, 2019 - Anti-programmed cell death-1 (anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD-1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations, including acute-onset type 1 diabetes. Acq...

Acquired generalized lipodystrophy under immune checkpoint inhibition.
https://doi.org/10.1111/bjd.18124
The British Journal of Dermatology; Haddad N, Vidal-Trecan T et. al.

May 12th, 2019 - Immune checkpoint inhibitors are now the standard of care in the treatment of several types of cancer. Cutaneous immune-related adverse events (irAEs) are usually of low grade and reversible, while endocrine irAEs are generally irreversible and ma...

Acquired Lipodystrophy Associated With Nivolumab in a Patient With Advanced Renal Cell ...
https://doi.org/10.1210/jc.2018-02221
The Journal of Clinical Endocrinology and Metabolism; Falcao CK, Cabral MCS et. al.

Feb 20th, 2019 - Lipodystrophy syndromes are rare disorders characterized by the selective loss of adipose tissue. We aimed to report a case of acquired generalized lipodystrophy possibly associated with nivolumab. A woman was referred to our Endocrinology Departm...

Case Report of Acquired Generalized Lipodystrophy Associated With Common Variable Immun...
https://doi.org/10.1210/jc.2018-00494
The Journal of Clinical Endocrinology and Metabolism; Halpern B, Nery M et. al.

May 31st, 2018 - Acquired generalized lipodystrophy (AGL), a rare disorder characterized by loss of subcutaneous adipose tissue, is estimated to occur in association with autoimmune diseases in ~25% of the cases. Common variable immunodeficiency (CVI) is a conditi...

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Drugs  1 results see all →

News  3 results

Table of Surrogate Endpoints That Were the Basis of Drug Approval or Licensure
http://www.fda.gov/drugs/development-resources/table-surrogate-endpoints-were-basis-drug-approval-or-licensure

What is the purpose of the Surrogate Endpoint Table? FDA’s surrogate endpoint table provides valuable information for drug developers on endpoints that may be considered and discussed with FDA for individual development programs. This table also f...

Myalept (Metreleptin) Approved for Generalized Lipodystrophy
https://www.medscape.com/viewarticle/821056

Feb 25th, 2014 - The US Food and Drug Administration (FDA) has approved Amylin Pharmaceuticals' Myalept (metreleptin for injection) as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized...

Myalept (Metreleptin) Approved for Generalized Lipodystrophy
https://www.staging.medscape.com/viewarticle/821056

Feb 25th, 2014 - The US Food and Drug Administration (FDA) has approved Amylin Pharmaceuticals' Myalept (metreleptin for injection) as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized...

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