ALLMedicine™ Adrenocortical Carcinoma Center
Research & Reviews 605 results
https://doi.org/10.1016/j.urolonc.2021.06.019
Urologic Oncology; Ginsburg KB, Chandra AA et. al.
Jul 25th, 2021 - To test for an association between oncological risk factors and overall survival in patients with non-metastatic adrenocortical carcinoma treated with adjuvant radiation therapy at high-risk for recurrence per NCCN guidelines. We analyzed data fro...
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European Journal of Drug Metabolism and Pharmacokinetics; Haider MS, Ahmad T et. al.
Jul 22nd, 2021 - Adrenocortical carcinoma (ACC) is a malignant tumor originating from the adrenal gland cortex with a heterogeneous but overall dismal prognosis in advanced stages. For more than 50 years, mitotane has remained a cornerstone for the treatment of AC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293912
Environmental Health Perspectives; Cardona B, Rudel RA
Jul 22nd, 2021 - Established breast cancer risk factors, such as hormone replacement therapy and reproductive history, are thought to act by increasing estrogen and progesterone (P4) activity. We aimed to use in vitro screening data to identify chemicals that incr...
https://doi.org/10.1016/j.surg.2021.04.045
Surgery Baechle JJ, Hanna DN et. al.
Jul 16th, 2021 - Immunotherapeutic response failure of adrenocortical carcinomas highlights a need for novel strategies targeting immune cell populations in the tumor microenvironment to overcome tumor resistance and enhance therapeutic response. A recent study ex...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262162
Pathology Oncology Research : POR; Krokker L, Szabó B et. al.
Jul 15th, 2021 - In vitro monolayer conditions are not able to reproduce the complexity of solid tumors, still, there is scarce information about the 3D cell culture models of endocrine tumor types. Therefore, our aim was to develop in vitro 3D tumor models by dif...
Guidelines 1 results
https://doi.org/10.1210/jc.2008-0104
The Journal of Clinical Endocrinology and Metabolism; Funder JW, Carey RM et. al.
Jun 17th, 2008 - Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, si...
Clinicaltrials.gov 18 results
https://clinicaltrials.gov/ct2/show/NCT03370718
May 4th, 2020 - PRIMARY OBJECTIVES: I. To estimate progression free survival at 4 months. SECONDARY OBJECTIVES: I. Best overall response rate. II. Overall survival (OS). III. Toxicity assessment by the Common Terminology Criteria for Adverse Events (CTCAE) versio...
https://clinicaltrials.gov/ct2/show/NCT00453895
Jan 31st, 2019 - Although a first randomized trial in patients with advanced ACC leading to the establishment of a first line cytotoxic chemotherapy is ongoing (FIRM-ACT), the failure rate even of this FIRM-ACT study is most likely clearly above 50%. Therefore, th...
https://clinicaltrials.gov/ct2/show/NCT01262235
Jan 16th, 2019 - This study will be a Phase I/II, open-label, non-randomized, dose-finding trial conducted at multiple clinical centers. The study is designed to determine the safety, tolerability and PK of TKM-080301 in adult patients with solid tumors or lymphom...
https://clinicaltrials.gov/ct2/show/NCT03723941
Oct 30th, 2018 - Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an annual rate of 0.5.2 cases per million population. Despite complete resection of early-stage disease recurrence rates in ACC are very high (60%.70%). Patients with Ki67 ≥ 10% ar...
https://clinicaltrials.gov/ct2/show/NCT00924989
Sep 5th, 2018 - Patients will be randomized 2:1 to receive either single agent OSI-906 (Arm A) or placebo (Arm B) and will be stratified according to prior systemic cytotoxic chemotherapy for ACC, and Eastern Cooperative Oncology Group (ECOG) performance status, ...
News 16 results
https://www.medscape.com/viewarticle/934790
Jul 29th, 2020 - A strategy that includes a urine steroid test along with imaging characteristics and tumor size criteria can significantly improve the challenging diagnosis of adrenocortical cancer, helping to avoid unnecessary, and often unsuccessful, further im...
https://reference.medscape.com/viewarticle/904250
Nov 5th, 2018 - Clinical practice guidelines for the management of adrenocortical carcinoma in adults were released in October 2018 by the European Society of Endocrinology.[1] Diagnosis Perform a detailed hormonal workup of all patients with suspected adrenocort...
https://reference.staging.medscape.com/viewarticle/904250
Nov 5th, 2018 - Clinical practice guidelines for the management of adrenocortical carcinoma in adults were released in October 2018 by the European Society of Endocrinology.[1] Diagnosis Perform a detailed hormonal workup of all patients with suspected adrenocort...
https://www.medscape.com/viewarticle/900291_6
Aug 9th, 2018 - Oncology Adrenocortical Carcinoma Advanced Breast Cancer Cancer Pain Management Constipation in Advanced Cancer HER2+ Advanced Breast Cancer
https://www.mdedge.com/internalmedicine/article/109105/pituitary-thyroid-adrenal-disorders/resection-recurrence-shows
Richard Mark Kirkner
May 25th, 2016 - BALTIMORE – Patients who have recurrent adrenocortical carcinoma appear to have one option to increase their survival: surgery that includes complete tumor resection – but it may a viable path only if the recurrence occurred a year or more after t.
