About 135 results

ALLMedicine™ Adrenomyeloneuropathy Center

Research & Reviews  49 results

Cognitive Functions in Adult-Onset Phenotypes of X-Linked Adrenoleukodystrophy.
Annals of Neurology; Schäfer L, Roicke H et. al.

Jun 10th, 2021 - X-linked adrenoleukodystrophy (X-ALD) is a rare genetic disorder characterized by progressive demyelination ranging from mild myelopathic forms (adrenomyeloneuropathy [AMN]) to severe cerebral variants (adult cerebral adrenoleukodystrophy [ACALD])...

Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in ...
Nature Communications; Weinhofer I, Rommer P et. al.

Mar 24th, 2021 - X-linked adrenoleukodystrophy (X-ALD), the most frequent monogenetic disorder of brain white matter, is highly variable, ranging from slowly progressive adrenomyeloneuropathy (AMN) to life-threatening inflammatory brain demyelination (CALD). In th...

Multiparametric in vivo analyses of the brain and spine identify structural and metabol...
NeuroImage. Clinical; Adanyeguh IM, Lou X et. al.

Jan 31st, 2021 - Progressive myelopathy causes severe handicap in men with adrenomyeloneuropathy (AMN), an X-linked disorder due to ABCD1 pathogenic variants. At present, treatments are symptomatic but disease-modifying therapies are under evaluation. Given the sm...

Adrenomyeloneuropathy Masquerading as Chronic Myelitis.
JAMA Neurology; Azar C, Shor N et. al.

Feb 25th, 2020 - Adrenomyeloneuropathy Masquerading as Chronic Myelitis.|2020|Azar C,Shor N,Nadjar Y,|

Anesthetic management of pediatric patients diagnosed with X-linked adrenoleukodystroph...
Paediatric Anaesthesia; Kloesel B, Dua N et. al.

Dec 17th, 2019 - X-linked adrenoleukodystrophy is a progressive demyelinating disease that primarily affects males with an incidence of 1:20 000-30 000. The disease has a wide spectrum of phenotypic expression and may include adrenal insufficiency, cerebral X-link...

see more →

Clinicaltrials.gov  4 results

Lentiviral Gene Therapy for X-ALD

Sep 19th, 2019 - X-linked adrenoleukodystrophy (X-ALD) is a devastating neurological disorder caused by mutations in the ABCD1 gene that encodes a peroxisomal ATP-binding cassette transporter (ABCD1). ABCD1 is responsible for transport of CoA-activated very long-c...

Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy

Aug 29th, 2018 - X-linked adrenoleukodystrophy (X-ALD), a [sex-linked] progressive neurodegenerative disease, is caused by a defect in the ABCD1 gene. The disease is expressed in multiple ways, but the most common adult form is adrenomyeloneuropathy (AMN), which r...

A Clinical Trial for AMN: Validation of Biomarkers of Oxidative Stress, Efficacy and Safety of a Mixture of Antioxidants

Sep 19th, 2016 - X-linked adrenoleukodystrophy is a rare, demyelinating and neurodegenerative disorder, due to a loss of function of a fatty acid transporter, the peroxisomal ABCD1protein. Its more frequent phenotype, the adrenomyeloneuropathy in adults, is charac...

A Phase III Trial of Lorenzo's Oil in Adrenomyeloneuropathy

Mar 2nd, 2012 - This is a double-masked placebo controlled study of glyceryl trioleate-glyceryl trierucate (Lorenzo's Oil (LO)) therapy in adrenomyeloneuropathy (AMN), the adult form of X-linked adrenoleukodystrophy (X-ALD). AMN is a slowly progressive distal axo...

see more →

Patient Education  1 results see all →