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About 2,687 results

ALLMedicine™ Ataxia Telangiectasia Center

Research & Reviews  1,335 results

T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges.
https://doi.org/10.1080/16078454.2021.1908725
Hematology (Amsterdam, Netherlands); Ahmed O, Felimban Y et. al.

Apr 12th, 2021 - Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present f...

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood ...
https://doi.org/10.3174/ajnr.A7107
AJNR. American Journal of Neuroradiology; Dineen RA, Blanchard CV et. al.

Apr 9th, 2021 - SWI hypointense cerebral lesions have been reported in adults with the inherited cerebellar neurodegenerative disorder ataxia telangiectasia. This study aims to establish the prevalence, age-dependency, and spatial distribution of these lesions in...

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Tel...
https://doi.org/10.1093/hmg/ddab074
Human Molecular Genetics; Suart CE, Perez AM et. al.

Mar 27th, 2021 - Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the ataxin-1 protein. Recent genetic correlational studies have implicated DNA damage repair pathways in modifying the ...

NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by impr...
https://doi.org/10.1111/acel.13329
Aging Cell; Yang B, Dan X et. al.

Mar 18th, 2021 - Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in premature aging diseases, including ataxia telangiectasia (A-T). Loss of mitochondrial function can drive age-related decline in the brain, but little is known abou...

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Guidelines  1 results

ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia.
https://doi.org/10.1183/16000617.0066-2015
European Respiratory Review : an Official Journal of the ... Bhatt JM, Bush A et. al.

Dec 1st, 2015 - Ataxia telangiectasia (A-T) is a rare, progressive, multisystem disease that has a large number of complex and diverse manifestations which vary with age. Patients with A-T die prematurely with the leading causes of death being respiratory disease...

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Drugs  1 results see all →

Clinicaltrials.gov  1,345 results

T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges.
https://doi.org/10.1080/16078454.2021.1908725
Hematology (Amsterdam, Netherlands); Ahmed O, Felimban Y et. al.

Apr 12th, 2021 - Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present f...

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood ...
https://doi.org/10.3174/ajnr.A7107
AJNR. American Journal of Neuroradiology; Dineen RA, Blanchard CV et. al.

Apr 9th, 2021 - SWI hypointense cerebral lesions have been reported in adults with the inherited cerebellar neurodegenerative disorder ataxia telangiectasia. This study aims to establish the prevalence, age-dependency, and spatial distribution of these lesions in...

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Tel...
https://doi.org/10.1093/hmg/ddab074
Human Molecular Genetics; Suart CE, Perez AM et. al.

Mar 27th, 2021 - Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the ataxin-1 protein. Recent genetic correlational studies have implicated DNA damage repair pathways in modifying the ...

NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by impr...
https://doi.org/10.1111/acel.13329
Aging Cell; Yang B, Dan X et. al.

Mar 18th, 2021 - Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in premature aging diseases, including ataxia telangiectasia (A-T). Loss of mitochondrial function can drive age-related decline in the brain, but little is known abou...

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News  3 results

Irinotecan shows promise for triple-negative breast cancer
https://www.mdedge.com/hematology-oncology/article/217772/breast-cancer/irinotecan-shows-promise-triple-negative-breast?channel=39313
Caleb Rans

Feb 24th, 2020 - The topoisomerase I (TOP1) inhibitor irinotecan could be effective in treating triple-negative breast cancer (TNBC), according to results from a preclinical study published in Science Translational Medicine. Florence Coussy, MD, PhD, of Institut C.

AT Children’s Project Advisors Elected to National Academy of Sciences
https://www.mdedge.com/neurology/article/116228/rare-diseases/childrens-project-advisors-elected-national-academy-sciences

Oct 1st, 2016 - Longtime scientific advisors to the AT (Ataxia Telangiectasia) Children’s Project Nathaniel Heintz, PhD, and Michael Kastan, MD, PhD, have been elected to the National Academy of Sciences.

Olaparib + paclitaxel for metastatic gastric cancer
https://www.mdedge.com/hematology-oncology/article/101954/gastroenterology/olaparib-paclitaxel-metastatic-gastric-cancer
Mary Ann Moon

Aug 17th, 2015 - Adding olaparib to second-line paclitaxel therapy for recurrent or metastatic gastric adenocarcinoma improved overall survival but not progression-free survival in a phase II clinical trial, investigators reported online Aug. 17 in Journal of Clin.

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Patient Education  2 results see all →