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About 20 results

ALLMedicine™ Aromatase Excess Syndrome Center

Research & Reviews  8 results

Local aromatase excess with recruitment of unusual promoters of CYP19A1 gene in prepube...
https://doi.org/10.1515/jpem-2021-0757
Journal of Pediatric Endocrinology & Metabolism : JPEM; Deberles E, Durand I et. al.

Jun 7th, 2022 - Gynecomastia may be due to aromatase excess in several diseases such as obesity and cancer. Aromatase excess syndrome (AEXS) is an autosomal dominant disorder caused by overexpression of CYP19A1. Germinal mutations occurring in AEXS include variou...

Congenital disorders of estrogen biosynthesis and action.
https://doi.org/10.1016/j.beem.2021.101580
Best Practice & Research. Clinical Endocrinology & Metabo... Fukami M, Ogata T

Sep 21st, 2021 - Estrogens regulate pubertal development and reproductive function in women, spermatogenesis in men, and bone turnover and metabolic conditions in individuals of both sexes. Estradiol, the major estrogen in humans, is synthesized from testosterone ...

Long-term Effect of Aromatase Inhibition in Aromatase Excess Syndrome.
https://doi.org/10.1210/clinem/dgab054
The Journal of Clinical Endocrinology and Metabolism; Binder G, Nakamura A et. al.

Jan 30th, 2021 - Aromatase excess syndrome (AEXS) is a very rare disorder characterized by prepubertal gynecomastia, bone age acceleration, and early growth arrest. Heterozygote submicroscopic rearrangements within the promotor of CYP19A1 result in overexpression ...

Aromatase excess syndrome in a Chinese boy due to a novel duplication at 15q21.2.
https://doi.org/10.1515/jpem-2018-0266
Journal of Pediatric Endocrinology & Metabolism : JPEM; Tan X, Wu X et. al.

Dec 12th, 2018 - Background Aromatase excess syndrome (AEXS) is a rare autosomal dominant disorder caused by CYP19A1 overexpression. Clinical manifestations of AEXS include pre- or peri-pubertal gynecomastia, advanced bone age and compromised adult height. Case pr...

Aromatase excess syndrome
https://rarediseases.info.nih.gov/diseases/12494/aromatase-excess-syndrome

Sep 1st, 2017 - The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 178345 Definition A rare, genetic endocrine disease characterized by increased levels of estrogen due to elevated ...

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