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About 185 results

ALLMedicine™ Alexander Disease Center

Research & Reviews  73 results

Type II Alexander disease with fragile X mental retardation 1 gene mutation.
https://doi.org/10.1016/j.clineuro.2021.107023
Clinical Neurology and Neurosurgery; Xu SY, Liang JL et. al.

Nov 21st, 2021 - Alexander disease (AxD) is a rare, autosomal dominant genetic disorder with an incidence of approximately 1 in 27,00.000. It is caused by a missense mutation in the GFAP gene encoding the glial fibrillary acidic protein. Fragile X-associated tremo...

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)
https://clinicaltrials.gov/ct2/show/NCT04849741

Oct 26th, 2021 - This is a Phase 1-3, multi-center, double-blind, placebo-controlled, multiple-ascending dose (MAD) study in up to 58 patients with AxD. Participants will be randomized in a 2:1 ratio to receive ION373 or matching placebo for a 60-week double-blind...

Palato-Lingual Tremor in a Child With Juvenile-Onset Alexander Disease.
https://doi.org/10.1016/j.pediatrneurol.2021.09.021
Pediatric Neurology; Almudhry M, Alotaibi M et. al.

Oct 23rd, 2021 - Palato-Lingual Tremor in a Child With Juvenile-Onset Alexander Disease.|2021|Almudhry M,Alotaibi M,Mir A,|

Clinical and radiological characteristics of older-adult-onset Alexander disease.
https://doi.org/10.1111/ene.15017
European Journal of Neurology; Yoshida T, Mizuta I et. al.

Jul 11th, 2021 - Alexander disease (ALXDRD) affects a wide range of ages from infancy to adulthood. However, only a few cases involving patients with older-adult onset over 65 years of age have been reported. In contrast, regarding in-house data, 10.6% of 85 cases...

Area Postrema Syndrome as the Initial Presentation of Alexander Disease.
https://doi.org/10.1212/WNL.0000000000012462
Neurology Renaldo F, Chalard F et. al.

Jul 9th, 2021 - Area Postrema Syndrome as the Initial Presentation of Alexander Disease.|2021|Renaldo F,Chalard F,Valence S,Burglen L,Rodriguez D,|diagnosis,genetics,pathology,diagnostic imaging,pathology,

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Clinicaltrials.gov  1 results

A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)
https://clinicaltrials.gov/ct2/show/NCT04849741

Oct 26th, 2021 - This is a Phase 1-3, multi-center, double-blind, placebo-controlled, multiple-ascending dose (MAD) study in up to 58 patients with AxD. Participants will be randomized in a 2:1 ratio to receive ION373 or matching placebo for a 60-week double-blind...

see more →