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About 405 results

ALLMedicine™ Choroideremia Center

Research & Reviews  149 results

AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results ...
https://doi.org/10.1016/j.ophtha.2022.06.006
Ophthalmology Aleman TS, Huckfeldt RM et. al.

Jun 18th, 2022 - To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human CHM-encoding cDNA in choroideremia (CHM). Prospective, open-label, non-randomized, dose-escalation, phase 1/2 clinica...

An Open Label Clinical Trial of Retinal Gene Therapy for Choroideremia
https://clinicaltrials.gov/ct2/show/NCT02077361

May 19th, 2022 - This is an open label study involving a total of 6 male patients. Screening and patient medical records will determine patient eligibility. Patients will receive a subretinal injection of the rAAV2.REP1 vector by a trained vitreoretinal surgeon in...

Repair of Rhegmatogenous Retinal Detachment in Choroideremia Secondary to Posterior Ext...
https://doi.org/10.3928/23258160-20220311-02
Ophthalmic Surgery, Lasers & Imaging Retina; Wang JC, Qian CX et. al.

Apr 14th, 2022 - Rhegmatogenous retinal detachment in choroideremia is a rare occurrence. The authors present a case of a 23-year-old man with choroideremia with a near-total rhegmatogenous retinal detachment. Fundus examination did not reveal any retinal breaks, ...

Natural History of the Progression of Choroideremia Study
https://clinicaltrials.gov/ct2/show/NCT03359551

Mar 25th, 2022 - This study was previously posted by NightstaRx Ltd. In October 2020, sponsorship of the trial was transferred to Biogen.

Short-term Assessment of Subfoveal Injection of Adeno-Associated Virus-Mediated hCHM Ge...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914909
JAMA Ophthalmology; Morgan JIW, Jiang YY et. al.

Mar 11th, 2022 - Subretinal injection for gene augmentation in retinal degenerations forcefully detaches the neural retina from the retinal pigment epithelium, potentially damaging photoreceptors and/or retinal pigment epithelium cells. To use adaptive optics scan...

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Clinicaltrials.gov  5 results

An Open Label Clinical Trial of Retinal Gene Therapy for Choroideremia
https://clinicaltrials.gov/ct2/show/NCT02077361

May 19th, 2022 - This is an open label study involving a total of 6 male patients. Screening and patient medical records will determine patient eligibility. Patients will receive a subretinal injection of the rAAV2.REP1 vector by a trained vitreoretinal surgeon in...

Natural History of the Progression of Choroideremia Study
https://clinicaltrials.gov/ct2/show/NCT03359551

Mar 25th, 2022 - This study was previously posted by NightstaRx Ltd. In October 2020, sponsorship of the trial was transferred to Biogen.

"Natural History" Study of Choroideremia
https://clinicaltrials.gov/ct2/show/NCT02994368

Jan 6th, 2022 - The purpose of this study is to understand the rate of progression of all stages of choroideremia using a variety of assessments performed in the clinic including visual field measures, specialized photography of the eye and participant-reported v...

THOR - Tübingen Choroideremia Gene Therapy Trial
https://clinicaltrials.gov/ct2/show/NCT02671539

Oct 27th, 2020 - Study name: THOR - Tübingen Choroideremia gene therapy trial open label Phase 2 clinical trial using an adeno-associated viral vector (AAV2) encoding Rab-escort protein 1 (REP1) Phase: Phase II Indication: Adult males with a clinical phenotype of ...

The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia
https://clinicaltrials.gov/ct2/show/NCT01654562

Oct 15th, 2014 - Primary objective: To examine the short-term effects of of simvastatin on the vision on males with choroideremia, evaluated by full-field scotopic threshold testing. The investigators hypothesize that they will see a reversible decrease in the dar...

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News  8 results

Prosthetic Retinal Implant: Long-term Results Promising
https://www.medscape.com/viewarticle/848280

Jul 17th, 2015 - A retinal prosthesis system can safely, effectively, and reliably restore enough visual function to patients with late-stage retinitis pigmentosa to improve object detection and overall well-being, according to findings from an international trial...

OCT Angiography May Better Diagnose, Manage Retinal Disease
https://www.medscape.com/viewarticle/844049

Apr 30th, 2015 - A new study shows how optical coherence tomography (OCT) angiography can be used to visualize common retinal diseases such as diabetic retinopathy, age-related macular degeneration, and choroideremia, which are major causes of blindness. Researche...

OCT Angiography May Better Diagnose, Manage Retinal Disease
https://www.staging.medscape.com/viewarticle/844049

Apr 30th, 2015 - A new study shows how optical coherence tomography (OCT) angiography can be used to visualize common retinal diseases such as diabetic retinopathy, age-related macular degeneration, and choroideremia, which are major causes of blindness. Researche...

Gene Therapy for Retinal Diseases Is Within Sight
https://www.medscape.com/viewarticle/824467

May 7th, 2014 - Advances in Vitreoretinal Disease Management Many vitreoretinal pathologies have witnessed impressive advances in their management over the past decade. Most of these advances have involved pharmacologic innovation aimed at controlling exudative d...

Gene Therapy for Retinal Diseases Is Within Sight
https://www.staging.medscape.com/viewarticle/824467

May 7th, 2014 - Advances in Vitreoretinal Disease Management Many vitreoretinal pathologies have witnessed impressive advances in their management over the past decade. Most of these advances have involved pharmacologic innovation aimed at controlling exudative d...

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