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ALLMedicine™ Aromatase Excess Syndrome Center

Research & Reviews  7 results

Congenital disorders of estrogen biosynthesis and action.
Best Practice & Research. Clinical Endocrinology & Metabo... Fukami M, Ogata T

Sep 21st, 2021 - Estrogens regulate pubertal development and reproductive function in women, spermatogenesis in men, and bone turnover and metabolic conditions in individuals of both sexes. Estradiol, the major estrogen in humans, is synthesized from testosterone ...

Long-term Effect of Aromatase Inhibition in Aromatase Excess Syndrome.
The Journal of Clinical Endocrinology and Metabolism; Binder G, Nakamura A et. al.

Jan 30th, 2021 - Aromatase excess syndrome (AEXS) is a very rare disorder characterized by prepubertal gynecomastia, bone age acceleration, and early growth arrest. Heterozygote submicroscopic rearrangements within the promotor of CYP19A1 result in overexpression ...

Aromatase excess syndrome in a Chinese boy due to a novel duplication at 15q21.2.
Journal of Pediatric Endocrinology & Metabolism : JPEM; Tan X, Wu X et. al.

Dec 12th, 2018 - Background Aromatase excess syndrome (AEXS) is a rare autosomal dominant disorder caused by CYP19A1 overexpression. Clinical manifestations of AEXS include pre- or peri-pubertal gynecomastia, advanced bone age and compromised adult height. Case pr...

Aromatase excess syndrome

Sep 1st, 2017 - The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 178345 Definition A rare, genetic endocrine disease characterized by increased levels of estrogen due to elevated ...

Aromatase inhibitors in pediatrics.
Nature Reviews. Endocrinology; Wit JM, Hero M et. al.

Oct 26th, 2011 - Aromatase, an enzyme located in the endoplasmic reticulum of estrogen-producing cells, catalyzes the rate-limiting step in the conversion of androgens to estrogens in many tissues. The clinical features of patients with defects in CYP19A1, the gen...

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