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About 2,695 results

ALLMedicine™ Ataxia Telangiectasia Center

Research & Reviews  1,339 results

A rational targeted therapy for platinum-resistant small-cell lung cancer.
https://doi.org/10.1016/j.ccell.2021.03.003
Cancer Cell; Drapkin BJ, Minna JD

Apr 13th, 2021 - Small-cell lung cancer (SCLC) is initially sensitive to platinum doublet chemotherapy, providing dramatic clinical benefit. Unfortunately, most SCLCs relapse and become resistant to further therapy. In this issue of Cancer Cell, Thomas et al. show...

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048383
Cancer Cell; Thomas A, Takahashi N et. al.

Apr 13th, 2021 - Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse primary sites that lack effective treatments. Using chemical genetic screens, we identified inhibition of ataxia telangiectasia and rad3 related (ATR), the pri...

T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges.
https://doi.org/10.1080/16078454.2021.1908725
Hematology (Amsterdam, Netherlands); Ahmed O, Felimban Y et. al.

Apr 12th, 2021 - Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present f...

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood ...
https://doi.org/10.3174/ajnr.A7107
AJNR. American Journal of Neuroradiology; Dineen RA, Blanchard CV et. al.

Apr 9th, 2021 - SWI hypointense cerebral lesions have been reported in adults with the inherited cerebellar neurodegenerative disorder ataxia telangiectasia. This study aims to establish the prevalence, age-dependency, and spatial distribution of these lesions in...

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Guidelines  1 results

ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia.
https://doi.org/10.1183/16000617.0066-2015
European Respiratory Review : an Official Journal of the ... Bhatt JM, Bush A et. al.

Dec 1st, 2015 - Ataxia telangiectasia (A-T) is a rare, progressive, multisystem disease that has a large number of complex and diverse manifestations which vary with age. Patients with A-T die prematurely with the leading causes of death being respiratory disease...

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Drugs  1 results see all →

Clinicaltrials.gov  1,349 results

A rational targeted therapy for platinum-resistant small-cell lung cancer.
https://doi.org/10.1016/j.ccell.2021.03.003
Cancer Cell; Drapkin BJ, Minna JD

Apr 13th, 2021 - Small-cell lung cancer (SCLC) is initially sensitive to platinum doublet chemotherapy, providing dramatic clinical benefit. Unfortunately, most SCLCs relapse and become resistant to further therapy. In this issue of Cancer Cell, Thomas et al. show...

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048383
Cancer Cell; Thomas A, Takahashi N et. al.

Apr 13th, 2021 - Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse primary sites that lack effective treatments. Using chemical genetic screens, we identified inhibition of ataxia telangiectasia and rad3 related (ATR), the pri...

T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges.
https://doi.org/10.1080/16078454.2021.1908725
Hematology (Amsterdam, Netherlands); Ahmed O, Felimban Y et. al.

Apr 12th, 2021 - Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present f...

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood ...
https://doi.org/10.3174/ajnr.A7107
AJNR. American Journal of Neuroradiology; Dineen RA, Blanchard CV et. al.

Apr 9th, 2021 - SWI hypointense cerebral lesions have been reported in adults with the inherited cerebellar neurodegenerative disorder ataxia telangiectasia. This study aims to establish the prevalence, age-dependency, and spatial distribution of these lesions in...

see more →

News  3 results

Irinotecan shows promise for triple-negative breast cancer
https://www.mdedge.com/hematology-oncology/article/217772/breast-cancer/irinotecan-shows-promise-triple-negative-breast?channel=39313
Caleb Rans

Feb 24th, 2020 - The topoisomerase I (TOP1) inhibitor irinotecan could be effective in treating triple-negative breast cancer (TNBC), according to results from a preclinical study published in Science Translational Medicine. Florence Coussy, MD, PhD, of Institut C.

AT Children’s Project Advisors Elected to National Academy of Sciences
https://www.mdedge.com/neurology/article/116228/rare-diseases/childrens-project-advisors-elected-national-academy-sciences

Oct 1st, 2016 - Longtime scientific advisors to the AT (Ataxia Telangiectasia) Children’s Project Nathaniel Heintz, PhD, and Michael Kastan, MD, PhD, have been elected to the National Academy of Sciences.

Olaparib + paclitaxel for metastatic gastric cancer
https://www.mdedge.com/hematology-oncology/article/101954/gastroenterology/olaparib-paclitaxel-metastatic-gastric-cancer
Mary Ann Moon

Aug 17th, 2015 - Adding olaparib to second-line paclitaxel therapy for recurrent or metastatic gastric adenocarcinoma improved overall survival but not progression-free survival in a phase II clinical trial, investigators reported online Aug. 17 in Journal of Clin.

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Patient Education  2 results see all →