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About 323 results

ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center

Research & Reviews  121 results

Sirolimus is effective in autoimmune lymphoproliferative syndrome-type III: A pedigree ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252363
International Journal of Immunopathology and Pharmacology; Gu H, Chen Z et. al.

Jul 1st, 2021 - Autoimmune lymphoproliferative syndrome (ALPS) usually presents in childhood with fever, nonmalignant splenomegaly, and lymphadenopathy along with cytopenia, which is caused by mutations in the FAS apoptotic pathway. The TCRαβ + CD4/CD8 double-neg...

Genetic characterization of short stature patients with overlapping features of growth ...
https://doi.org/10.1210/clinem/dgab437
The Journal of Clinical Endocrinology and Metabolism; Andrews A, Maharaj A et. al.

Jun 18th, 2021 - Growth hormone insensitivity (GHI) in children is characterized by short stature, functional IGF-I deficiency and normal or elevated serum GH concentrations. The clinical and genetic etiology of GHI is expanding. We undertook genetic characterizat...

Complete CD95/FAS deficiency due to complex homozygous germline TNFRSF6 mutations in an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177709
Clinical Immunology (Orlando, Fla.); Tessarin G, Mazza C et. al.

May 17th, 2021 - Hepatocellular carcinoma (HCC) is driven by repeated rounds of inflammation, leading to fibrosis, cirrhosis, and, ultimately, cancer. A critical step in HCC formation is the transition from fibrosis to cirrhosis, which is associated with a change ...

Clinical, immunological, and genetic features in 780 patients with autoimmune lymphopro...
https://doi.org/10.1111/pai.13535
Pediatric Allergy and Immunology : Official Publication O... Hafezi N, Zaki-Dizaji M et. al.

May 9th, 2021 - Autoimmune lymphoproliferative syndrome (ALPS) is a group of genetic disorders characterized by early-onset lymphoproliferation, autoimmune cytopenias, and susceptibility to lymphoma. The majority of ALPS patients carry heterozygous germline mutat...

The challenge of early diagnosis of autoimmune lymphoproliferative syndrome in children...
https://doi.org/10.1093/rheumatology/keab361
Rheumatology (Oxford, England); Mendonça LO, Matucci-Cerinic C et. al.

Apr 29th, 2021 - To test the usefulness of an extended panel of lymphocyte subsets (LS) in combination with Oliveira's diagnostic criteria for the identification of autoimmune lymphoproliferative syndrome (ALPS) in children referred to a pediatric rheumatology cen...

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Guidelines  1 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953894
Blood Oliveira JB, Bleesing JJ et. al.

Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

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Clinicaltrials.gov  5 results

Study of Autoimmune Lymphoproliferative Syndrome (ALPS)
https://clinicaltrials.gov/ct2/show/NCT00001350

Feb 26th, 2020 - The purpose of this family based natural history protocol is to allow for patients, and relatives of patients to be screened for Autoimmune Lymphoproliferative Syndrome (ALPS) and related disorders of apoptosis, RAS associated leukoproliferative d...

Sirolimus for Autoimmune Disease of Blood Cells
https://clinicaltrials.gov/ct2/show/NCT00392951

Nov 19th, 2019 - Patients with autoimmune destruction of hematopoietic cells frequently have severe and debilitating disease requiring aggressive and frequent medical management. These patients are often treated with non-specific immunosuppressive medications with...

Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) to Evaluate Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-associated Lymphoma
https://clinicaltrials.gov/ct2/show/NCT00068146

Jul 5th, 2018 - The Autoimmune Lymphoproliferative Syndrome (ALPS) is an inherited disorder associated with defective lymphocyte apoptosis, which is clinically characterized by prominent non-malignant lymphadenopathy, hepatosplenomegaly and overt autoimmune disea...

Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome
https://clinicaltrials.gov/ct2/show/NCT00013689

Mar 4th, 2008 - The Autoimmune Lymphoproliferative Syndrome is an inherited disease associated with a defect of lymphocyte apoptosis, lymphoproliferation and autoimmunity. Although, there are treatments for many of its autoimmune complications, there currently is...

Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome
https://clinicaltrials.gov/ct2/show/NCT00065390

Mar 4th, 2008 - The Autoimmune Lymphoproliferative Syndrome (ALPS) is an inherited disease associated with a defect of lymphocyte apoptosis that leads to lymphoproliferation and autoimmunity. Although, there are treatments for many of its complications, there cur...

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News  2 results

Monitor Kids on TNF Inhibitors for Rare Cancers
https://www.medpagetoday.com/rheumatology/generalrheumatology/71877

Mar 20th, 2018 - Long-term screening for cancer -- especially for unusual neoplasms -- is an important aspect of safety monitoring among pediatric patients receiving tumor necrosis factor (TNF) inhibitors, Canadian researchers cautioned. Rare solid tumors were ide...

Immunosuppressant can treat autoimmune cytopenias
https://www.mdedge.com/hematology-oncology/article/187516/anemia/immunosuppressant-can-treat-autoimmune-cytopenias
HT Staff

Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.

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