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About 53 results

ALLMedicine™ Adenosine Deaminase 2 Deficiency Center

Research & Reviews  21 results

Polyarteritis nodosa: an evolving primary systemic vasculitis.
https://doi.org/10.1080/00325481.2022.2088940
Postgraduate Medicine; Springer JM, Byram K

Jun 17th, 2022 - Polyarteritis nodosa (PAN) is a primary form of vasculitis characterized by inflammation of primarily medium-sized arteries. Several key events have shaped the current spectrum of the disease including the separation of a subgroup with microscopic...

Hematopoietic stem cell transplantation in systemic autoinflammatory diseases - the fir...
https://doi.org/10.1080/1744666X.2022.2078704
Expert Review of Clinical Immunology; Signa S, Dell'Orso G et. al.

May 17th, 2022 - Primary immune regulatory disorders encompass a range of clinical conditions caused by different defects of immune regulatory mechanisms, including systemic autoinflammatory diseases (AIDs). Allogeneic hematopoietic stem cell transplantation may b...

Type I interferon-related kidney disorders.
https://doi.org/10.1016/j.kint.2022.02.031
Kidney International; Lodi L, Mastrolia MV et. al.

Mar 28th, 2022 - Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-...

TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2).
https://doi.org/10.1016/j.jaci.2021.10.030
The Journal of Allergy and Clinical Immunology; Deuitch NT, Yang D et. al.

Nov 16th, 2021 - Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disorder caused by a loss of functional ADA2 protein. TNF inhibition (TNFi) has proven to be highly effective in treating inflammatory manifestations. We sough...

Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405196
Blood Advances; Zoccolillo M, Brigida I et. al.

Aug 24th, 2021 - Adenosine deaminase 2 deficiency (DADA2) is a rare inherited disorder that is caused by autosomal recessive mutations in the ADA2 gene. Clinical manifestations include early-onset lacunar strokes, vasculitis/vasculopathy, systemic inflammation, im...

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