ALLMedicine™ Adenosine Deaminase 2 Deficiency Center
Research & Reviews 21 results
https://doi.org/10.1080/00325481.2022.2088940
Postgraduate Medicine; Springer JM, Byram K
Jun 17th, 2022 - Polyarteritis nodosa (PAN) is a primary form of vasculitis characterized by inflammation of primarily medium-sized arteries. Several key events have shaped the current spectrum of the disease including the separation of a subgroup with microscopic...
https://doi.org/10.1080/1744666X.2022.2078704
Expert Review of Clinical Immunology; Signa S, Dell'Orso G et. al.
May 17th, 2022 - Primary immune regulatory disorders encompass a range of clinical conditions caused by different defects of immune regulatory mechanisms, including systemic autoinflammatory diseases (AIDs). Allogeneic hematopoietic stem cell transplantation may b...
https://doi.org/10.1016/j.kint.2022.02.031
Kidney International; Lodi L, Mastrolia MV et. al.
Mar 28th, 2022 - Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-...
https://doi.org/10.1016/j.jaci.2021.10.030
The Journal of Allergy and Clinical Immunology; Deuitch NT, Yang D et. al.
Nov 16th, 2021 - Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disorder caused by a loss of functional ADA2 protein. TNF inhibition (TNFi) has proven to be highly effective in treating inflammatory manifestations. We sough...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405196
Blood Advances; Zoccolillo M, Brigida I et. al.
Aug 24th, 2021 - Adenosine deaminase 2 deficiency (DADA2) is a rare inherited disorder that is caused by autosomal recessive mutations in the ADA2 gene. Clinical manifestations include early-onset lacunar strokes, vasculitis/vasculopathy, systemic inflammation, im...
