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ALLMedicine™ Autosomal Dominant Hyper Ige Syndrome Center

Research & Reviews  6 results

Hyper IgE syndromes: clinical and molecular characteristics.
https://doi.org/10.1111/imcb.12209
Immunology and Cell Biology; Al-Shaikhly T, Ochs HD

Sep 29th, 2018 - Hyper IgE syndromes comprise a group of rare primary immunodeficiency disorders characterized by a triad of atopic dermatitis, recurrent skin and lung infections along with elevated IgE levels. Job syndrome or autosomal dominant hyper IgE syndrome...

TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063472
The Journal of Clinical Investigation; Myles IA, Anderson ED et. al.

Jul 24th, 2018 - Autosomal dominant hyper IgE syndrome (AD-HIES), or Job's syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent Staphylococcus aureus skin abscesses are a defining feature of this syndrome. A widely hel...

Autosomal dominant hyper IgE syndrome
https://rarediseases.info.nih.gov/diseases/6800/autosomal-dominant-hyper-ige-syndrome

Jul 14th, 2015 - Autosomal dominant hyper IgE syndrome (AD-HIES), formerly known as Job syndrome, affects several body systems including the immune system. AD-HIES is characterized by abnormally high levels of an immune system protein called immunoglobulin E (IgE)...

Variable clinical expressivity of STAT3 mutation in hyperimmunoglobulin E syndrome: gen...
https://doi.org/10.1007/s10875-014-9988-4
Journal of Clinical Immunology; Wolach O, Kuijpers T et. al.

Jan 24th, 2014 - Autosomal dominant Hyper IgE syndrome (AD-HIES) is a rare and complex primary immunodeficiency that affects multiple systems. Mutations in signal transducer and activator of transcription 3 (STAT3) gene cause AD-HIES. These mutations have a domina...

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