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About 843 results

ALLMedicine™ Adult-onset Still's Disease Center

Research & Reviews  312 results

Systematic review on the use of biologics in adult-onset still's disease.
https://doi.org/10.1016/j.semarthrit.2022.152139
Seminars in Arthritis and Rheumatism; Fautrel B, Patterson J et. al.

Nov 29th, 2022 - This systematic review (SR) describes the efficacy and safety of biologic disease modifying anti-rheumatic drugs (bDMARDs) for patients with adult-onset Still's disease (AOSD). Three randomised controlled trials (RCTs), one retrospective case seri...

AIM2 and NLRC4-driven inflammasome activation in adult-onset Still's disease and the pr...
https://doi.org/10.1007/s10067-022-06443-1
Clinical Rheumatology; Duan M, Shen M et. al.

Nov 24th, 2022 - This study aimed to explore the changes of four major inflammasomes in adult-onset Still's disease (AOSD) and preliminarily evaluate the therapeutic effect of carboxyamidotriazole (CAI), which has previously been reported to have the significant a...

Pulmonary hypertension in connective tissue diseases: epidemiology, pathogenesis, and t...
https://doi.org/10.1007/s10067-022-06446-y
Clinical Rheumatology; Cansu DÜ, Korkmaz C

Nov 18th, 2022 - Pulmonary hypertension (PH) is a clinical condition characterized by increased pulmonary arterial pressure arising from a heterogeneous range of diseases that has a deteriorating effect on the quality of life and may cause early mortality if left ...

New-onset inflammatory arthritis after COVID-19 vaccination: A systematic review.
https://doi.org/10.1111/1756-185X.14482
International Journal of Rheumatic Diseases; Chen CC, Chen CJ

Nov 14th, 2022 - To analyze the clinical patterns of new-onset inflammatory arthritis after COVID-19 vaccination among patients without pre-existing rheumatic or autoimmune diseases. Case reports and series of new-onset inflammatory arthritis after COVID-19 vaccin...

Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 co...
https://doi.org/10.1038/s41467-022-34560-7
Nature Communications; Jia J, Wang M et. al.

Nov 11th, 2022 - Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of ferritin remains largely unknown. Here we show in an animal...

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Clinicaltrials.gov  13 results

Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE
https://clinicaltrials.gov/ct2/show/NCT05001737

Sep 13th, 2022 - Study NI-0501-14 is a two-cohort trial that enrolls subjects who are diagnosed with sHLH/MAS (MAS being a form of secondary HLH) and who are presenting an inadequate response to high doses of GCs. These subjects will be enrolled in 2 cohorts as pe...

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
https://clinicaltrials.gov/ct2/show/NCT03510442

Sep 9th, 2022 - The purpose of this protocol is to study the natural history, genetics and pathophysiology of systemic juvenile idiopathic arthritis (sJIA), adult-onset Still s disease (AOSD) and related inflammatory conditions. One of seven subtypes of juvenile ...

A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing M...
https://clinicaltrials.gov/ct2/show/NCT03311854

May 17th, 2022 - Macrophage Activation Syndrome (MAS) is a rare, life-threatening condition characterized by uncontrolled hyperinflammation which may develop on the background of systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD). ...

Treatment of Macrophage Activation Syndrome (MAS) With Anakinra
https://clinicaltrials.gov/ct2/show/NCT02780583

Jan 4th, 2022 - Macrophage activation syndrome (MAS) is a disorder whereby the immune system generates very high levels of substances (cytokines) that promote inflammation to the extent dysfunction occurs in multiple organ systems which if unchecked, is frequentl...

Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals
https://clinicaltrials.gov/ct2/show/NCT05102695

Nov 5th, 2021 - Inflammatory markers are often elevated in patients with COVID-19, notably C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), IL-6and ferritin. Multiple prior studies have found correlations between various biomarkers and clinical out...

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News  11 results

NICE Recommends Anakinra for Paediatric and Adult-onset Still’s Disease
https://www.medscape.com/viewarticle/948506

Apr 1st, 2021 - The National Institute for Health and Care Excellence (NICE) has recommended anakinra (Kineret, Swedish Orphan Biovitrum) as a treatment option for Still’s disease in adults and systemic juvenile idiopathic arthritis in children. Anakinra is an in...

FDA Approves Canakinumab (Ilaris), First Drug for Adult-Onset Still's Disease
https://www.medscape.com/viewarticle/932625

Jun 19th, 2020 - The Food and Drug Administration has expanded the indications for canakinumab (Ilaris) to include all patients with active Still's disease older than 2 years, adding adult-onset Still's disease (AOSD) to a previous approval for juvenile-onset Stil...

Rheumatologists: On the COVID-19 Front Line
https://www.medpagetoday.com/infectiousdisease/covid19/85545

Mar 22nd, 2020 - Rheumatologists may be in a unique position to consult and help in the management of patients with severe disease caused by COVID-19, said experts. "Some of the drugs that appear promising for patients who are severely ill with COVID-19 are those ...

Lethal Lung Disease and Biologics: Is There a Link?
https://www.medpagetoday.com/rheumatology/arthritis/84098

Dec 24th, 2019 - This story was originally published Sept. 4, 2019. As part of MedPage Today's year-end review of 2019's top stories, we are republishing it along with an update on what has happened since. A new, potentially life-threatening parenchymal lung disea...

Lethal Lung Disease and Biologics: Is There a Link?
https://www.medpagetoday.com/rheumatology/arthritis/81966

Sep 4th, 2019 - A new, potentially life-threatening parenchymal lung disease is increasingly being detected in patients with systemic juvenile idiopathic arthritis (sJIA), according to recent reports. Systemic JIA is distinct from other forms of JIA in that the a...

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Patient Education  1 results see all →