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About 995 results

ALLMedicine™ Alpha-1 Antitrypsin Deficiency Center

Research & Reviews  308 results

Alpha-1 Asthma Overlap Syndrome: a Clinical Overview.
https://doi.org/10.1007/s11882-022-01036-z 10.1034/j.1399-0004.2003.00143.x 10.1056/NEJMra1910234 10.1146/annurev-genom-083117-021651 10.1513/AnnalsATS.201311-405PS 10.1183/09031936.00138707 10.1164/rccm.201904-0769OC 10.1371/journal.pone.0141542 10.1111/j.1600-065X.2011.01029.x 10.1111/resp.13251 10.1067/mai.2000.106155 10.1164/ajrccm.160.3.9812110 10.1111/all.13985 10.1164/ajrccm/138.2.327 10.1164/rccm.200703-489OC 10.1016/S0009-9260(05)80011-X 10.1164/ajrccm.162.4.9906120 10.1378/chest.117.2.415 10.1146/annurev.immunol.22.012703.104716 10.1016/j.jaci.2010.01.003 10.1183/09059180.00007413 10.1016/j.rmed.2005.11.017 10.1016/j.anai.2013.09.019 10.1164/ajrccm.156.1.9508014 10.1378/chest.123.3.765 10.3949/ccjm.61.6.461 10.1378/chest.128.4.1989 10.1183/09031936.97.10102260 10.1378/chest.119.3.737 10.2147/COPD.S8577 10.1111/j.0954-6820.1978.tb08452.x 10.1378/chest.103.3.812 10.1016/j.rmed.2006.01.009 10.1080/02770900701540028 10.1053/rmed.2001.1237 10.1186/s13601-018-0231-x 10.1164/ajrccm.157.2.9703070 10.1172/JCI115738 10.1172/JCI41196 10.3109/01902149509031769 10.1164/ajrccm.153.4.8616573 10.1136/thx.35.4.298 10.4049/jimmunol.1500038 10.1016/j.biocel.2007.02.017 10.1038/nrdp.2016.51 10.1016/j.chest.2018.04.039 10.2500/aap.2017.38.4031 10.1164/ajrccm.160.5.9901055 10.1183/09031936.00159408 10.1016/S0140-6736(15)60860-1 10.1183/09031936.98.12051028
Current Allergy and Asthma Reports; Izquierdo M, Rawal H et. al.

May 21st, 2022 - Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic diseases that is associated with severe complications and yet remains underdiagnosed. The pulmonary symptoms of both AATD and asthma include cough, excessive sputum production...

COPD screening for asymptomatic adults? USPSTF weighs in, again
https://www.mdedge.com/chestphysician/article/254452/copd/copd-screening-asymptomatic-adults-uspstf-weighs-again
Mark S. Lesney, PhD, MDedge News

May 10th, 2022 - Screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults has no net benefit, according to a U. S.

Respreeza® Self-administration and Learning Program (AmAREtTI Study)
https://clinicaltrials.gov/ct2/show/NCT04262284

May 9th, 2022 - According to the Respreeza® Summary of Product Characteristics, the initial infusions must be administered under the supervision of a health professional experienced in the treatment of alpha-1 antitrypsin deficiency, although subsequent infusions...

Cystic fibrosis and alpha-1 antitrypsin deficiency: case report and review of literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063355
BMC Pediatrics; Jaspers E, Van Dijck I et. al.

May 4th, 2022 - This case report describes a child born with both cystic fibrosis (CF) and alpha-1 antitrypsin deficiency (A1ATD). Both are autosomal recessive inherited diseases, mainly affecting the lungs and the liver. The combination of both diseases together...

Study of ARO-AAT in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)
https://clinicaltrials.gov/ct2/show/NCT03946449

May 4th, 2022 - Participants will be enrolled to receive multiple subcutaneous injections of ARO-AAT. All eligible participants will require a pre-dose biopsy completed as part of the study within the screening window. All participants will undergo an End of Stud...

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Guidelines  3 results

Non-invasive diagnosis and follow-up of rare genetic liver diseases.
https://doi.org/10.1016/j.clinre.2021.101768
Clinics and Research in Hepatology and Gastroenterology; Sobesky R, Guillaud O et. al.

Aug 1st, 2021 - Rare genetic liver diseases can result in multi-systemic damage, which may compromise the patient's prognosis. Wilson's disease and alpha-1 antitrypsin deficiency must be investigated in any patient with unexplained liver disease. Cystic fibrosis ...

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
https://doi.org/10.1038/ajg.2016.517
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.

Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...

Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373286
Canadian Respiratory Journal; Marciniuk DD, Hernandez P et. al.

Apr 27th, 2012 - Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 o...

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Clinicaltrials.gov  34 results

Respreeza® Self-administration and Learning Program (AmAREtTI Study)
https://clinicaltrials.gov/ct2/show/NCT04262284

May 9th, 2022 - According to the Respreeza® Summary of Product Characteristics, the initial infusions must be administered under the supervision of a health professional experienced in the treatment of alpha-1 antitrypsin deficiency, although subsequent infusions...

Study of ARO-AAT in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)
https://clinicaltrials.gov/ct2/show/NCT03946449

May 4th, 2022 - Participants will be enrolled to receive multiple subcutaneous injections of ARO-AAT. All eligible participants will require a pre-dose biopsy completed as part of the study within the screening window. All participants will undergo an End of Stud...

Longitudinal Study of Mitochondrial Hepatopathies
https://clinicaltrials.gov/ct2/show/NCT01148550

Apr 22nd, 2022 - This study will be conducted as part of the NIH-supported Childhood Liver Disease Research and Education Network (ChiLDREN). ChiLDREN is investigating rare cholestatic liver diseases of childhood: alpha-1 antitrypsin deficiency (A1AT), Alagille's ...

Optimization of Donor-Recipient Matching in Lung Transplantation
https://clinicaltrials.gov/ct2/show/NCT05195853

Mar 31st, 2022 - Lung transplantation is the curative treatment for end-stage respiratory failure involving highly selected patients. In 2018, the International Transplant Registry counts 69200 lung transplants among 260 transplant centers. Between 2010 and June 2...

Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency
https://clinicaltrials.gov/ct2/show/NCT03815396

Feb 16th, 2022 - This is an open-label, 2-part, dose-escalating, Phase 1 study of INBRX-101 (rhAAT-Fc). Part 1 will consist of single ascending dose (SAD) administration of INBRX-101 and Part 2 will consist of multiple ascending dose (MAD) administrations of INBRX...

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News  46 results

COPD Screening for Asymptomatic Adults? USPSTF Weighs In, Again
https://www.medscape.com/viewarticle/973787

May 11th, 2022 - Screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults has no net benefit, according to a U.S. Preventive Services Task Force (USPSTF) reassessment of its 2016 screening recommendations. The new recommendation is in line...

COPD screening for asymptomatic adults? USPSTF weighs in, again
https://www.mdedge.com/chestphysician/article/254452/copd/copd-screening-asymptomatic-adults-uspstf-weighs-again
Mark S. Lesney, PhD, MDedge News

May 10th, 2022 - Screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults has no net benefit, according to a U. S.

Deja Vu All Over Again; Delay of Game: NFL Vaccine Pushback; Third FDA Advisor Quits
https://www.medpagetoday.com/infectiousdisease/covid19/93049

Jun 11th, 2021 - Note that some links may require registration or subscription. Here we go again. As cruise lines struggle to recover from COVID-19, two passengers aboard a Royal Caribbean ship tested positive for coronavirus; all crew and passengers over 16 were ...

HCC Etiologic Risk Factors and Global Prevalence
https://www.onclive.com/view/hcc-etiologic-risk-factors-and-global-prevalence

Apr 2nd, 2021 - Minsig Choi, MD: What are the etiology risk factors in the development of hepatocellular cancer? We all know that hepatocellular cancer or liver cancer is caused by a chronic irritation or inflammations. Usually the most common causes of this irri...

Point Mutation May Help Explain Different National COVID-19 Death Rates
https://www.medscape.com/viewarticle/938411

Oct 2nd, 2020 - NEW YORK (Reuters Health) - Ethnic differences in the frequencies of alpha-1 antitrypsin deficiency alleles might contribute to national differences in COVID-19 fatality rates, researchers report. "It was interesting to see how one point mutation ...

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Patient Education  7 results see all →