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About 1,028 results

ALLMedicine™ Wilms' Tumor Center

Research & Reviews  378 results

Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic...
https://doi.org/10.1016/j.jphs.2022.03.003
Journal of Pharmacological Sciences; Tomita N, Hotta Y et. al.

May 6th, 2022 - Podocyte injury is responsible for nephrotic syndrome. Previously, we found that tadalafil, a phosphodiesterase 5 inhibitor, might have protective effects on podocytes. Here, we investigated the effects of tadalafil in a nephrotic syndrome model a...

First-in-human study of WT1 recombinant protein vaccination in elderly patients with AM...
https://doi.org/10.1007/s00262-022-03202-8 10.1111/j.1365-2141.2008.07260.x 10.1016/j.blre.2019.04.005 10.1056/NEJMoa1516192 10.1200/jco.2016.71.2208 10.1159/000131375 10.1038/343774a0 10.1016/0092-8674(90)90601-a 10.1038/sj.leu.2404624 10.1182/blood-2010-01-262543 10.1182/blood-2018-03-837468 10.1046/j.0902-4441.2003.00185.x 10.1182/blood-2005-10-4025 10.1038/sj.leu.2405018 10.1038/leu.2010.33 10.1016/j.leukres.2015.10.014 10.1200/jco.2007.15.2058 10.1200/jco.2008.16.0333 10.1038/leu.2013.111 10.1182/blood.V90.3.1217 10.1111/ejh.13010 10.3389/fimmu.2015.00036 10.1182/blood.V96.4.1480 10.1182/blood-2009-10-250993 10.1038/sj.leu.2403186 10.1182/blood-2009-02-202598 10.1038/leu.2011.343 10.1002/ajh.21387 10.1182/bloodadvances.2017014175 10.1186/s40164-018-0093-x 10.1111/bjh.14768 10.1080/21645515.2017.1382787 10.1200/jco.2009.22.4865 10.1016/j.immuni.2021.05.002 10.1126/science.1198704 10.1038/nbt.4314 10.1002/cyto.a.22625 10.1182/blood-2009-07-235358 10.1007/s00277-017-3150-3 10.1073/pnas.0405884101 10.1182/blood-2007-08-108241 10.1182/blood-2017-04-780155 10.1159/000481353 10.1074/jbc.M809456200 10.1016/j.ebiom.2015.11.041 10.1007/s00262-010-0929-7
Cancer Immunology, Immunotherapy : CII; Kreutmair S, Pfeifer D et. al.

Apr 28th, 2022 - Wilms' tumor 1 (WT1) protein is highly immunogenic and overexpressed in acute myeloid leukemia (AML), consequently ranked as a promising target for novel immunotherapeutic strategies. Here we report our experience of a phase I/II clinical trial (N...

A Case of Severe Aortic Stenosis after Aortic Valve Neocuspidization Using Autologous P...
https://doi.org/10.5761/atcs.cr.21-00269
Annals of Thoracic and Cardiovascular Surgery : Official ... Mikami T, Uchiyama H et. al.

Mar 25th, 2022 - A 56-year-old man with a history of left nephrectomy for Wilms' tumor on chronic hemodialysis underwent aortic valve neocuspidization using autologous pericardium (Ozaki procedure) for aortic stenosis (AS) due to a bicuspid aortic valve 6 years ag...

Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor
https://clinicaltrials.gov/ct2/show/NCT00379340

Mar 25th, 2022 - PRIMARY OBJECTIVES: I. Determine the 4-year event-free survival (EFS) of patients with stage IV favorable histology (FH) Wilms' tumor with pulmonary metastases only who have complete resolution of pulmonary lesions without whole lung irradiation t...

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Drugs  10 results see all →

Clinicaltrials.gov  10 results

Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor
https://clinicaltrials.gov/ct2/show/NCT00379340

Mar 25th, 2022 - PRIMARY OBJECTIVES: I. Determine the 4-year event-free survival (EFS) of patients with stage IV favorable histology (FH) Wilms' tumor with pulmonary metastases only who have complete resolution of pulmonary lesions without whole lung irradiation t...

Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or St...
https://clinicaltrials.gov/ct2/show/NCT00352534

Jan 13th, 2022 - PRIMARY OBJECTIVES: I. Evaluate the overall and event-free survival of younger patients with newly diagnosed stage I favorable histology Wilms' tumor (< 2 years of age and < 550gms) treated with nephrectomy only (very low risk), or with newly diag...

Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
https://clinicaltrials.gov/ct2/show/NCT00369564

Aug 11th, 2021 - OBJECTIVES: Primary Compare the effect of glutamic acid vs placebo, in terms of decreasing neurotoxicity as measured by a scored neurologic examination, in young patients undergoing vincristine-containing treatment for Wilms' tumor, rhabdomyosarco...

Dose Escalation Trial of WT1-Sensitized T Cells for Residual or Relapsed Leukemia After Allogeneic Hematopoietic Progenitor Cell Transplantation
https://clinicaltrials.gov/ct2/show/NCT00620633

Mar 2nd, 2021 - This study will test the safety of giving you specialized white cells from your donor. They are called WT1 sensitized T cells. They have been grown in the lab and are immunized against a protein. The protein is called the Wilms' tumor protein, or ...

Comparing the Impact of Cancer on Quality of Life Between Survivors of Childhood Solid Tumors and Leukemia
https://clinicaltrials.gov/ct2/show/NCT03430752

Jun 28th, 2019 - In general, cancer can be divided into two main categories: blood cancer and solid tumors. Leukemia refer to the cancers in blood while solid tumors refer to the cancers which involve the formation of an abnormal mass without any liquid or cysts. ...

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News  8 results

JTCC Leading Enrollment for WIZARD Study Evaluating DSP-7888 in Recurrent Glioblastoma
https://www.onclive.com/view/jtcc-leading-enrollment-for-wizard-study-evaluating-dsp7888-in-recurrent-glioblastoma

Dec 20th, 2020 - John Theurer Cancer Center at Hackensack Meridian Health Hackensack University Medical Center announced today that it is leading enrollment worldwide for WIZARD 201G, a global Phase 2 study in glioblastoma (GBM). The trial, sponsored by Boston Bio...

Clinical Abstracts From Overseas: June 24, 2010
https://www.onclive.com/view/articles_gr_jan2008

Dec 5th, 2020 - %u25BA SWEDEN What Do Genes Have to Do With Cancer Survival? It is well known that genetic phenotype has an effect on cancer incidence, such as breast cancer appearing in members of the same family. Does genetic phenotype also influence ...

Successful CAR T-Cell Tx Needs Good T Cells to Begin With
https://www.medscape.com/viewarticle/894212

Mar 20th, 2018 - Chimeric antigen receptor (CAR) T-cell therapy has produced some dramatic responses in pediatric acute lymphoblastic leukemia (ALL), but the responses have been less spectacular in other hematologic malignancies, and they have been disappointing i...

Chemo Boost Reduces Relapse in High-Risk Wilms' Tumor
https://www.medscape.com/viewarticle/844672

May 14th, 2015 - CHICAGO — For children with a high-risk form of Wilms' tumor, the augmentation of standard therapy with additional agents can improve outcomes, according to two new studies. The high-risk form of Wilms' tumor, a rare kidney cancer that mainly affe...

Chemo Boost Reduces Relapse in High-Risk Wilms' Tumor
https://www.staging.medscape.com/viewarticle/844672

May 14th, 2015 - CHICAGO — For children with a high-risk form of Wilms' tumor, the augmentation of standard therapy with additional agents can improve outcomes, according to two new studies. The high-risk form of Wilms' tumor, a rare kidney cancer that mainly affe...

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Patient Education  5 results see all →