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About 2,293 results

ALLMedicine™ Adrenocortical Carcinoma Center

Research & Reviews  827 results

Rare benign adrenal lesions.
https://doi.org/10.1093/ejendo/lvad036
European Journal of Endocrinology; Dogra P, Sundin A et. al.

Mar 22nd, 2023 - While most benign lesions of the adrenal glands represent either an adrenocortical adenoma or a myelolipoma, the advent and frequent use of high-resolution radiological investigations have led to relatively increased incidental discovery of rare a...

Adrenocortical Carcinoma: Role of Adjuvant and Neoadjuvant Therapy.
https://doi.org/10.1016/j.soc.2022.10.005
Surgical Oncology Clinics of North America; Kenney L, Hughes M

Mar 17th, 2023 - Adjuvant and neoadjuvant chemotherapy in the treatment of adrenocortical carcinoma (ACC) is limited by few existing trials, most of which are retrospective. The drug mitotane has been used for the treatment of ACC, although existing guidelines onl...

Genetic Testing for Adrenal Tumors-What the Contemporary Surgeon Should Know.
https://doi.org/10.1016/j.soc.2022.10.007
Surgical Oncology Clinics of North America; Bates MF, Sorensen MJ

Mar 17th, 2023 - Surgical diseases of the adrenal gland include pheochromocytoma/paraganglioma, primary hyperaldosteronism, Cushing syndrome, and adrenocortical carcinoma. These conditions may be associated with familial syndromes, and genetic testing is available...

European Multicenter Study on Role of Lymph Node Dissection in Surgical Management of Adrenal Cortical Carcinoma
https://clinicaltrials.gov/ct2/show/NCT05763524

Mar 10th, 2023 - Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of only 0.5 to 2.0 per million population and a high rate of mortality: Stage I, II and III 5 years-survival is respectively 84%, 63% and 24%, while medium surv...

The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma
https://clinicaltrials.gov/ct2/show/NCT05344027

Mar 8th, 2023 - Background: Adrenocortical Carcinoma (ACC) is a rare malignancy of the adrenal cortex. The annual incidence of ACC is thought to be between 0.5-2.0 cases per million. Adjunctive therapy with mitotane may be offered post- surgically to minimise ris...

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Guidelines  3 results

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021,...
https://doi.org/10.6004/jnccn.2021.0001
Journal of the National Comprehensive Cancer Network : JN... Daly MB, Pal T et. al.

Jan 7th, 2021 - The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants associated with increased risk of breast, ovarian, and pancreatic cancer and r...

Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practi...
https://doi.org/10.1530/EJE-16-0467
European Journal of Endocrinology; Fassnacht M, Arlt W et. al.

Jul 9th, 2016 - : By definition, an adrenal incidentaloma is an asymptomatic adrenal mass detected on imaging not performed for suspected adrenal disease. In most cases, adrenal incidentalomas are nonfunctioning adrenocortical adenomas, but may also represent con...

Case detection, diagnosis, and treatment of patients with primary aldosteronism: an end...
https://doi.org/10.1210/jc.2008-0104
The Journal of Clinical Endocrinology and Metabolism; Funder JW, Carey RM et. al.

Jun 17th, 2008 - Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, si...

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Clinicaltrials.gov  49 results

European Multicenter Study on Role of Lymph Node Dissection in Surgical Management of Adrenal Cortical Carcinoma
https://clinicaltrials.gov/ct2/show/NCT05763524

Mar 10th, 2023 - Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of only 0.5 to 2.0 per million population and a high rate of mortality: Stage I, II and III 5 years-survival is respectively 84%, 63% and 24%, while medium surv...

The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma
https://clinicaltrials.gov/ct2/show/NCT05344027

Mar 8th, 2023 - Background: Adrenocortical Carcinoma (ACC) is a rare malignancy of the adrenal cortex. The annual incidence of ACC is thought to be between 0.5-2.0 cases per million. Adjunctive therapy with mitotane may be offered post- surgically to minimise ris...

Pembrolizumab in the Treatment of Advanced, Progressive Adrenocortical Carcinoma.
https://clinicaltrials.gov/ct2/show/NCT05563467

Mar 7th, 2023 - This study is a national, multicenter, interventional, phase II clinical trial on the use of pembrolizumab in advanced adrenocortical carcinoma, with confirmed progression within 6 months, following EDP or EDP-M ( etoposide, doxorubicin, cisplatin...

Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Study
https://clinicaltrials.gov/ct2/show/NCT04400474

Feb 23rd, 2023 - CABATEN is a multicohort phase II study of cabozantinib plus atezolizumab in advanced and progressive tumors from endocrine system. Hypothesis: The main hypothesis is that the administration of cabozantinib plus atezolizumab will improve the proba...

A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma
https://clinicaltrials.gov/ct2/show/NCT04187404

Feb 21st, 2023 - EO2401 is an innovative cancer peptide therapeutic vaccine based on the homologies between Tumor Associated Antigens and microbiome-derived peptides that will be administered in combination with nivolumab to generate preliminary safety and efficac...

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News  34 results

New Adrenalectomy Guidelines Cover Surgery, Multispecialty Care
https://www.medscape.com/viewarticle/979619

Aug 23rd, 2022 - New adrenalectomy guidelines from the American Association of Endocrine Surgeons are aimed at assisting both specialist and general surgeons with perioperative adrenal care, including guidance on management of adrenal incidentalomas. Published onl...

Adjuvant Mitotane Fails to Improve RFS in Patients with ACC at Low/Intermediate Risk of Recurrence
https://www.onclive.com/view/adjuvant-mitotane-fails-to-improve-rfs-in-patients-with-acc-at-low-intermediate-risk-of-recurrence

Feb 20th, 2022 - The utilization of mitotane (Lysodren) in the adjuvant setting did not produce significant benefit for patients with adrenocortical carcinoma (ACC) at low or intermediate risk of recurrence, according to findings from the phase 3 ADIUVO trial (NCT...

Investigational PI3K-γ Inhibitor Eganelisib Plus Nivolumab Elicits Early Efficacy in Head and Neck Cancer, Melanoma
https://www.onclive.com/view/investigational-pi3k--inhibitor-eganelisib-plus-nivolumab-elicits-early-efficacy-in-head-and-neck-cancer-melanoma

Oct 6th, 2021 - Treatment with the combination of eganelisib (IPI-549), a selective PI3K-γ inhibitor, and nivolumab (Opdivo) demonstrated encouraging clinical activity and a favorable safety profile in patients with head and neck squamous cell carcinoma (HNSCC), ...

Exceptional Responder Provides Treatment Clues in Bladder Cancer
https://www.onclive.com/view/exceptional-responder-provides-treatment-clues-in-bladder-cancer

Oct 6th, 2021 - Nikhil Wagle, MD An exceptional responder with advanced urothelial carcinoma experienced a complete radiologic response lasting 13.8 months following treatment with the combination of everolimus (Afinitor) and pazopanib (Votrient), according to r...

Dr. McGregor on Immunotherapy in Rare Genitourinary Cancers
https://www.onclive.com/view/dr-mcgregor-on-immunotherapy-in-rare-genitourinary-cancers

Oct 6th, 2021 - Bradley McGregor, MD, physician, Genitourinary Oncology program, Dana-Farber Cancer Institute, and instructor of medicine, Harvard Medical School, discusses immunotherapy in rare genitourinary (GU) cancers. Clinical trials are generally geared to...

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Patient Education  4 results see all →