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About 1,045 results

ALLMedicine™ Alpha-1 Antitrypsin Deficiency Center

Research & Reviews  323 results

COVID-19's impact on care practice for alpha-1-antitrypsin deficiency patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885054
BMC Health Services Research; Calle Rubio M, López-Campos JL et. al.

Feb 1st, 2023 - Patients with alpha-1 antitrypsin deficiency (AATD), commonly categorized as a rare disease, have been affected by the changes in healthcare management brought about by COVID-19. This study's aim was to identify the changes that have taken place i...

Optimization of Donor-Recipient Matching in Lung Transplantation
https://clinicaltrials.gov/ct2/show/NCT05195853

Dec 30th, 2022 - Lung transplantation is the curative treatment for end-stage respiratory failure involving highly selected patients. In 2018, the International Transplant Registry counts 69200 lung transplants among 260 transplant centers. Between 2010 and June 2...

Bronchoscopic Lung Volume Reduction in Patients with Emphysema due to Alpha-1 Antitryps...
https://doi.org/10.1159/000528182
Respiration; International Review of Thoracic Diseases; Everaerts S, Hartman JE et. al.

Dec 23rd, 2022 - Bronchoscopic lung volume reduction using one-way endobronchial valves (EBVs) is a valid therapy for severe emphysema patients. However, alpha-1 antitrypsin (AAT)-deficient patients were excluded from the majority of clinical trials investigating ...

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756677
Respiratory Research; Miravitlles M, Turner AM et. al.

Dec 17th, 2022 - Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded with the objective of characterising the ...

Alpha-1 Antitrypsin Deficiency Adult Liver Study
https://clinicaltrials.gov/ct2/show/NCT02014415

Dec 14th, 2022 - Alpha-1 Antitrypsin Deficiency (AATD) is a genetic disorder resulting in a low level of a protein called alpha-1 antitrypsin (AAT). This deficiency can cause life-threatening liver disease and/or lung disease at various ages. Some patients experie...

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Guidelines  3 results

Non-invasive diagnosis and follow-up of rare genetic liver diseases.
https://doi.org/10.1016/j.clinre.2021.101768
Clinics and Research in Hepatology and Gastroenterology; Sobesky R, Guillaud O et. al.

Aug 1st, 2021 - Rare genetic liver diseases can result in multi-systemic damage, which may compromise the patient's prognosis. Wilson's disease and alpha-1 antitrypsin deficiency must be investigated in any patient with unexplained liver disease. Cystic fibrosis ...

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
https://doi.org/10.1038/ajg.2016.517
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.

Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...

Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373286
Canadian Respiratory Journal; Marciniuk DD, Hernandez P et. al.

Apr 27th, 2012 - Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 o...

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Clinicaltrials.gov  35 results

Optimization of Donor-Recipient Matching in Lung Transplantation
https://clinicaltrials.gov/ct2/show/NCT05195853

Dec 30th, 2022 - Lung transplantation is the curative treatment for end-stage respiratory failure involving highly selected patients. In 2018, the International Transplant Registry counts 69200 lung transplants among 260 transplant centers. Between 2010 and June 2...

Alpha-1 Antitrypsin Deficiency Adult Liver Study
https://clinicaltrials.gov/ct2/show/NCT02014415

Dec 14th, 2022 - Alpha-1 Antitrypsin Deficiency (AATD) is a genetic disorder resulting in a low level of a protein called alpha-1 antitrypsin (AAT). This deficiency can cause life-threatening liver disease and/or lung disease at various ages. Some patients experie...

Longitudinal Study of Mitochondrial Hepatopathies
https://clinicaltrials.gov/ct2/show/NCT01148550

Nov 22nd, 2022 - This study will be conducted as part of the NIH-supported Childhood Liver Disease Research and Education Network (ChiLDREN). ChiLDREN is investigating rare cholestatic liver diseases of childhood: alpha-1 antitrypsin deficiency (A1AT), Alagille's ...

The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study
https://clinicaltrials.gov/ct2/show/NCT00500123

Nov 7th, 2022 - Genetic testing for alpha-1 antitrypsin deficiency is sometimes delayed despite established testing indications. All genetic tests have risks and possible benefits. The ACT study evaluates the population demographics, reasons for testing, and outc...

Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function
https://clinicaltrials.gov/ct2/show/NCT05582798

Oct 17th, 2022 - Bronchiectasis is a debilitating chronic disease associated with a vicious cycle of lung inflammation, infection and failure of mucociliary clearance. It affects up to 566/100,000 patients in Europe and the prevalence is increasing. Excess neutrop...

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News  47 results

COPD inhaler therapy: A path to success
https://www.mdedge.com/familymedicine/article/257727/pulmonology/copd-inhaler-therapy-path-success
MDedge Family Medicine; Michael Arnold, DO, FAAFP, Cate Vordtriede, PharmD, BCPS et. al.

Sep 12th, 2022 - Managing chronic obstructive pulmonary disease (COPD) presents a significant challenge to busy clinicians in many ways, especially when one is approaching the long list of inhaled pharmaceutical agents with an eye toward a cost-effective, patient-.

COPD Screening for Asymptomatic Adults? USPSTF Weighs In, Again
https://www.medscape.com/viewarticle/973787

May 11th, 2022 - Screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults has no net benefit, according to a U.S. Preventive Services Task Force (USPSTF) reassessment of its 2016 screening recommendations. The new recommendation is in line...

COPD screening for asymptomatic adults? USPSTF weighs in, again
https://www.mdedge.com/chestphysician/article/254452/copd/copd-screening-asymptomatic-adults-uspstf-weighs-again
Mark S. Lesney, PhD, MDedge News

May 10th, 2022 - Screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults has no net benefit, according to a U. S.

Deja Vu All Over Again; Delay of Game: NFL Vaccine Pushback; Third FDA Advisor Quits
https://www.medpagetoday.com/infectiousdisease/covid19/93049

Jun 11th, 2021 - Note that some links may require registration or subscription. Here we go again. As cruise lines struggle to recover from COVID-19, two passengers aboard a Royal Caribbean ship tested positive for coronavirus; all crew and passengers over 16 were ...

HCC Etiologic Risk Factors and Global Prevalence
https://www.onclive.com/view/hcc-etiologic-risk-factors-and-global-prevalence

Apr 2nd, 2021 - Minsig Choi, MD: What are the etiology risk factors in the development of hepatocellular cancer? We all know that hepatocellular cancer or liver cancer is caused by a chronic irritation or inflammations. Usually the most common causes of this irri...

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Patient Education  10 results see all →