ALLMedicine™ Alpha-1 Antitrypsin Deficiency Center
Research & Reviews 251 results
https://doi.org/10.1186/s12885-022-09190-3 10.1016/j.soc.2016.02.001 10.5334/aogh.2419 10.1016/S0140-6736(17)33326-3 10.1016/j.canlet.2013.12.010 10.1093/jnci/djw295 10.1016/j.lungcan.2009.04.005 10.2147/OTT.S242579 10.1007/s10555-015-9563-3 10.1172/JCI112524 10.1021/bi00316a003 10.1164/rccm.168.7.818 10.1016/0009-8981(67)90181-7 10.1111/joim.12239 10.1152/ajplung.00179.2014 10.1189/jlb.0212071 10.1016/S1470-2045(04)01414-7 10.1038/onc.2017.66 10.1172/JCI0216782 10.1002/1097-0142(197610)38:4<1655::AID-CNCR2820380435>3.0.CO;2-F 10.1016/j.tranon.2020.100914 10.1073/pnas.98.2.581 10.1001/archinte.168.10.1097 10.1016/j.arcmed.2006.05.006 10.21037/atm-20-1180 10.1513/AnnalsATS.201510-671KV
BMC Cancer; Tubío-Pérez RA, Torres-Durán M et. al.
Jan 21st, 2022 - Lung cancer (LC) is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking, genetic factors, including alpha-1 antitrypsi...
https://clinicaltrials.gov/ct2/show/NCT05195853
Jan 19th, 2022 - Lung transplantation is the curative treatment for end-stage respiratory failure involving highly selected patients. In 2018, the International Transplant Registry counts 69200 lung transplants among 260 transplant centers. Between 2010 and June 2...
https://doi.org/10.1080/17476348.2022.2027755
Expert Review of Respiratory Medicine; Ghosh AJ, Hobbs BD
Jan 14th, 2022 - Alpha-1 antitrypsin deficiency occurs in individuals with deleterious genetic mutations on both chromosomes (maternal and paternal) in SERPINA1, the gene encoding the alpha-1 antitrypsin protein. There has been substantial progress in understandin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743984
International Journal of Chronic Obstructive Pulmonary Di... Greulich T, Albert A et. al.
Jan 14th, 2022 - Augmentation therapy (AT) is the only specific treatment licensed for patients with alpha-1 antitrypsin deficiency (AATD) associated lung disease. Since patients with severe AATD may have a very different prognosis and AT requires intravenous infu...
https://clinicaltrials.gov/ct2/show/NCT05146882
Dec 29th, 2021 - This is a Phase 2, multicenter, open-label extension of Study DCR-A1AT-201, designed to evaluate the long-term safety and further characterize the pharmacodynamics (PD) of belcesiran in adult patients with PiZZ AATLD.
Guidelines 3 results
https://doi.org/10.1016/j.clinre.2021.101768
Clinics and Research in Hepatology and Gastroenterology; Sobesky R, Guillaud O et. al.
Aug 1st, 2021 - Rare genetic liver diseases can result in multi-systemic damage, which may compromise the patient's prognosis. Wilson's disease and alpha-1 antitrypsin deficiency must be investigated in any patient with unexplained liver disease. Cystic fibrosis ...
https://doi.org/10.1038/ajg.2016.517
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.
Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373286
Canadian Respiratory Journal; Marciniuk DD, Hernandez P et. al.
Apr 27th, 2012 - Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 o...
Clinicaltrials.gov 17 results
https://clinicaltrials.gov/ct2/show/NCT05195853
Jan 19th, 2022 - Lung transplantation is the curative treatment for end-stage respiratory failure involving highly selected patients. In 2018, the International Transplant Registry counts 69200 lung transplants among 260 transplant centers. Between 2010 and June 2...
https://clinicaltrials.gov/ct2/show/NCT05146882
Dec 29th, 2021 - This is a Phase 2, multicenter, open-label extension of Study DCR-A1AT-201, designed to evaluate the long-term safety and further characterize the pharmacodynamics (PD) of belcesiran in adult patients with PiZZ AATLD.
https://clinicaltrials.gov/ct2/show/NCT03815396
Oct 13th, 2021 - This is an open-label, 2-part, dose-escalating, Phase 1 study of INBRX-101 (rhAAT-Fc). Part 1 will consist of single ascending dose (SAD) administration of INBRX-101 and Part 2 will consist of multiple ascending dose (MAD) administrations of INBRX...
https://clinicaltrials.gov/ct2/show/NCT01379469
Oct 12th, 2021 - The primary objective is to determine if Carbamazepine therapy in patients with severe liver disease due to Alpha-1-Antitrypsin Deficiency leads to a significant reduction in the hepatic accumulation of ATZ. The other objectives are: To determine ...
https://clinicaltrials.gov/ct2/show/NCT03946449
Apr 1st, 2021 - Participants will be enrolled to receive multiple subcutaneous injections of ARO-AAT. All eligible participants will require a pre-dose biopsy completed as part of the study within the screening window. All participants will undergo an End of Stud...
News 30 results
https://www.medscape.com/viewarticle/938411
Oct 2nd, 2020 - NEW YORK (Reuters Health) - Ethnic differences in the frequencies of alpha-1 antitrypsin deficiency alleles might contribute to national differences in COVID-19 fatality rates, researchers report. "It was interesting to see how one point mutation ...
https://www.staging.medscape.com/viewarticle/938411
Oct 2nd, 2020 - NEW YORK (Reuters Health) - Ethnic differences in the frequencies of alpha-1 antitrypsin deficiency alleles might contribute to national differences in COVID-19 fatality rates, researchers report. "It was interesting to see how one point mutation ...
https://reference.medscape.com/viewarticle/936001_3
Sep 18th, 2020 - Answer 2/5 Which of the following conditions presents in a similar way to AADC deficiency? Your peers chose: Gaucher disease 0% Mucopolysaccharidosis 0% Alpha-1 antitrypsin deficiency 0% Tetrahydrobiopterin (BH4) deficiency 0% BH4 deficiency prese...
https://www.reuters.com/article/brief-dicerna-receives-orphan-drug-desig/brief-dicerna-receives-orphan-drug-designation-from-u-s-fda-for-dcr-a1at-for-treatment-of-alpha-1-antitrypsin-deficiency-idUSASA00I7R
Mar 18th, 2020 - March 18 (Reuters) - Dicerna Pharmaceuticals Inc: * DICERNA RECEIVES ORPHAN DRUG DESIGNATION FROM U.S. FOOD AND DRUG ADMINISTRATION FOR DCR-A1AT FOR TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY * DICERNA PHARMACEUTICALS - EXPECTS TO DOSE FIRST PATI...
https://www.mdedge.com/dermatology/article/210356/business-medicine/sixty-five-roses
Brett M. Coldiron, MD
Oct 19th, 2019 - Like many of you, my wife and I took the DNA plunge for fun and spit in the cup. She is genetically perfect, but I, however, am a carrier for alpha-1 anti-trypsin deficiency, hemochromatosis, and like 1 in 19 Irish people, cystic fibrosis.
