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About 125 results

ALLMedicine™ Alpha-mannosidosis Center

Research & Reviews  38 results

Long-term safety and efficacy of velmanase alfa treatment in children under 6 years of ...
https://doi.org/10.1002/jimd.12602
Journal of Inherited Metabolic Disease; Guffon N, Konstantopoulou V et. al.

Mar 1st, 2023 - Alpha-mannosidosis (AM) is a rare, autosomal recessive, lysosomal storage disorder caused by alpha-mannosidase deficiency that leads to the accumulation of mannose-rich oligosaccharides. AM symptoms and severity vary among individuals; consequentl...

Biomarker for Mannosidosis Disease (BioMannosidosis)
https://clinicaltrials.gov/ct2/show/NCT03264040

Feb 13th, 2023 - Alpha-Mannosidosis is a rare lysosomal storage disorder of the Glycoprotein family of diseases and is closely related to Mucopolysaccharidoses. Alpha-Mannosidosis was first described by Dr Oekerman, from Lund in Sweden in 1967. There is another va...

Mortality in patients with alpha-mannosidosis: a review of patients' data and the liter...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308362
Orphanet Journal of Rare Diseases; Hennermann JB, Raebel EM et. al.

Jul 24th, 2022 - Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder (LSD) caused by reduced activity of alpha-mannosidase. Clinical manifestations include skeletal dysmorphism, mental impairment, hearing loss and recurrent infections. The ...

European Alpha-Mannosidosis Participant
https://clinicaltrials.gov/ct2/show/NCT03651245

Jun 13th, 2022 - Alpha-Mannosidosis is a lysosomal storage disorder of the Glycoprotein family of diseases and is closely related to Mucopolysaccharidoses.It is a rare inherited disorder that causes problems in many organs and tissues of the body. Affected individ...

Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis
https://clinicaltrials.gov/ct2/show/NCT02998879

Oct 26th, 2021 - The Primary endpoints of the study include: Safety and tolerability of velmanase alfa as per Adverse events (AEs, including IRR), vital signs, laboratory parameters (hematology, biochemistry and urinanalysis) Detection of anti-velmanase alfa antib...

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Drugs  1 results see all →

Clinicaltrials.gov  9 results

Biomarker for Mannosidosis Disease (BioMannosidosis)
https://clinicaltrials.gov/ct2/show/NCT03264040

Feb 13th, 2023 - Alpha-Mannosidosis is a rare lysosomal storage disorder of the Glycoprotein family of diseases and is closely related to Mucopolysaccharidoses. Alpha-Mannosidosis was first described by Dr Oekerman, from Lund in Sweden in 1967. There is another va...

European Alpha-Mannosidosis Participant
https://clinicaltrials.gov/ct2/show/NCT03651245

Jun 13th, 2022 - Alpha-Mannosidosis is a lysosomal storage disorder of the Glycoprotein family of diseases and is closely related to Mucopolysaccharidoses.It is a rare inherited disorder that causes problems in many organs and tissues of the body. Affected individ...

Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis
https://clinicaltrials.gov/ct2/show/NCT02998879

Oct 26th, 2021 - The Primary endpoints of the study include: Safety and tolerability of velmanase alfa as per Adverse events (AEs, including IRR), vital signs, laboratory parameters (hematology, biochemistry and urinanalysis) Detection of anti-velmanase alfa antib...

A Placebo-Controlled Phase 3 Trial of Repeated Lamazym Treatment of Subjects With Alpha-Mannosidosis
https://clinicaltrials.gov/ct2/show/NCT01681953

Aug 3rd, 2020 - The overall objective of this trial is to evaluate the efficacy and safety of repeated Lamazym i.v. treatment, compared with placebo, in subjects 5-35 years of age with alpha-Mannosidosis

The Natural History of Alpha-Mannosidosis
https://clinicaltrials.gov/ct2/show/NCT00498420

Aug 3rd, 2020 - Definition: Human alpha-mannosidosis is a rare genetic disorder, caused by the lack of lysosomal alpha-mannosidase, resulting in mental retardation, skeletal changes, hearing loss and recurrent infections. The lack of alpha-mannosidase causes a di...

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News  2 results

Nurse Pleads Not Guilty to Amputation; Bruce Willis' Dementia; Defy Mifeprex Order?
https://www.medpagetoday.com/nursing/nursing/103154

Feb 17th, 2023 - Note that some links may require subscriptions. A Wisconsin nurse entered a not guilty plea over charges that she amputated a patient's frostbitten foot without consent. (AP) Half of kids 5 and under don't eat a daily vegetable and a third don't e...

EMA Handed Down Fewer Positive Drug Opinions in 2018
https://www.medscape.com/viewarticle/907402

Jan 9th, 2019 - In 2018, the European Medicines Agency (EMA) recommended marketing authorization for 84 new medicines, down from 92 in 2017. The 84 medicines given a thumbs up by EMA's Committee for Medicinal Products for Human Use include 42 agents with a new ac...

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