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About 4,768 results

ALLMedicine™ Hypokalemia Center

Research & Reviews  1,130 results

Dent-2 disease with a Bartter-like phenotype caused by the Asp631Glu mutation in the OC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097321
BMC Nephrology; Drosataki E, Maragkou S et. al.

May 14th, 2022 - Dent disease is an X-linked disorder characterized by low molecular weight proteinuria (LMWP), hypercalciuria, nephrolithiasis and chronic kidney disease (CKD). It is caused by mutations in the chloride voltage-gated channel 5 (CLCN5) gene (Dent d...

Long-term complications of primary distal renal tubular acidosis.
https://doi.org/10.1007/s00467-022-05546-w 10.1016/j.jpeds.2013.10.085 10.1016/j.kint.2016.12.017 10.1007/s00467-016-3573-4 10.1097/01.ASN.0000023430.92674.E5 10.1007/s12098-020-03318-8 10.1007/s00467-018-3965-8 10.1093/ndt/gfy409 10.1053/j.ackd.2018.05.005 10.1007/s00467-006-0417-7 10.1093/ndt/gfab171 10.1038/ki.2011.336 10.1172/JCI108962 10.1007/s00467-021-05066-z 10.1007/s00467-021-05068-x 10.1681/ASN.V1261228 10.1038/ki.1993.372 10.1038/ki.1997.26 10.1007/s00467-009-1169-y 10.1056/NEJM198207223070403 10.1046/j.1523-1755.2001.0590031086.x 10.1046/j.1523-1755.2002.00656.x 10.1093/ndt/15.7.975 10.1016/j.semnephrol.2006.12.001 10.1053/j.ackd.2018.05.003 10.1053/j.ajkd.2019.03.427 10.1001/jama.1972.03200070059009 10.1159/000115814 10.1111/j.1365-2796.1993.tb00999.x 10.1186/s13256-019-2056-1 10.12968/hmed.2015.76.11.664 10.1159/000509841 10.1016/S0140-6736(00)02218-2 10.1093/ndt/gfi049 10.1007/s40620-016-0370-x 10.1172/JCI106537 10.1159/000186522 10.1159/000187869 10.1186/1471-2369-12-16 10.1056/NEJM199002083220601 10.1097/HJH.0b013e328126855b 10.1152/ajpcell.1983.244.5.C429 10.1681/ASN.2008040441 10.1093/ndt/gfp160 10.2169/internalmedicine.54.9421 10.1007/s00467-020-04685-2 10.1111/cge.14011 10.2215/CJN.17541120 10.1053/j.ajkd.2009.02.014 10.1681/ASN.2008111205 10.1053/j.ajkd.2019.07.016 10.1016/j.xkme.2021.03.012 10.1016/S0140-6736(13)60311-6 10.1172/JCI112973 10.1681/ASN.2017060600 10.1681/ASN.2005121305 10.1681/ASN.2017080840 10.1152/ajpcell.00024.2007 10.1017/S0022215107009747 10.1111/j.1399-0004.2012.01891.x 10.3390/audiolres11030040 10.4172/1747-0862.1000013 10.1046/j.1523-1755.1999.00756.x 10.1038/ki.2009.258 10.1111/cge.13418 10.1007/s00467-020-04747-5 10.1016/j.kint.2019.09.026 10.1038/srep14827 10.3389/fped.2017.00191
Pediatric Nephrology (Berlin, Germany); Santos F, Gil-Peña H

May 12th, 2022 - The clinical manifestations of primary distal renal tubular acidosis usually begin in childhood, but the disease is caused by a genetic defect that persists throughout life. This review focuses on the complications of distal tubular acidosis that ...

Stroke-mimicking unilateral hypokalemic paralysis: A case report and literature review.
https://doi.org/10.1016/j.ajem.2022.04.042
The American Journal of Emergency Medicine; Liu X, Han K et. al.

May 9th, 2022 - Unilateral paralysis is an alarming symptom with broad differential diagnoses, including stroke, Todd's paralysis, myelopathy, and peripheral neuropathy. Hypokalemic paralysis (HP), a neuromuscular disorder associated with muscle dysfunction, is c...

Gitelman syndrome with normocalciuria - a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069753
BMC Nephrology; Flisiński M, Skalska E et. al.

May 6th, 2022 - Gitelman Syndrome (GS) is a hereditary tubulopathy associated with a biallelic inactivating mutations of the SLC12A3 gene encoding the thiazide-sensitive sodium-chloride cotransporter (NCCT). The typical clinical manifestation is a hypokalemic met...

Glucocorticoid receptor blockers.
https://doi.org/10.1007/s11102-022-01227-x 10.1210/jcem-57-4-863 10.1210/jcem-59-1-25 10.1210/jcem-61-3-536 10.1159/000314224 10.1210/jc.2011-3350 10.4158/EP12149.RA 10.1210/jc.2014-1843 10.1186/s40842-020-00105-4 10.1002/cpdd.389 10.3389/fendo.2021.662865 10.1097/JCP.0000000000001470 10.1016/S2213-8587(21)00235-7
Pituitary Molitch ME

May 5th, 2022 - Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome. Although originally developed as an abortifacient due to its blockade of the progesterone receptor, a number of case reports do...

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Guidelines  1 results

Case detection, diagnosis, and treatment of patients with primary aldosteronism: an end...
https://doi.org/10.1210/jc.2008-0104
The Journal of Clinical Endocrinology and Metabolism; Funder JW, Carey RM et. al.

Jun 17th, 2008 - Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, si...

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Drugs  527 results see all →

Clinicaltrials.gov  23 results

Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
https://clinicaltrials.gov/ct2/show/NCT02665117

Feb 11th, 2022 - CTD- induced metabolic side effects were though to be dependent on hypokalemia, but subsequent studies suggested that CTD - induced side effects were independent from hypokalemia. On the other hand, magnesium depletion has been linked to increased...

Amiloride in Nephrotic Syndrome
https://clinicaltrials.gov/ct2/show/NCT05079789

Oct 15th, 2021 - The monocenter randomized-controlled AMILOR trial investigates the efficacy of the ENaC blocker amiloride in reducing edema in nephrotic syndrome compared with standard therapy with the loop diuretic furosemide. Patients with acute nephrotic syndr...

Epidemiology of Long QTand Asian Sudden Death in Sleep
https://clinicaltrials.gov/ct2/show/NCT00005367

Apr 27th, 2021 - BACKGROUND: Sudden and unexplained death in sleep (SUDS) is a leading cause of death of young men in several Asian populations. The immediate cause is ventricular fibrillation in the absence of known disease. A strong environmental component may b...

Hydroxychloroquine in SARS-CoV-2 (COVID-19) Pneumonia Trial
https://clinicaltrials.gov/ct2/show/NCT04382625

Feb 5th, 2021 - Novel coronavirus SARS-CoV-2 was first identified during the outbreak in Wuhan, China in December 2019 with the now resulting pandemic. Aggressive supportive care is the mainstay of treatment currently and rescue with lung protective mechanical ve...

Extension Study in Primary Distal Renal Tubular Acidosis
https://clinicaltrials.gov/ct2/show/NCT03831152

Apr 24th, 2020 - Open-label study involving longitudinal assessment of the continued safety, tolerability, and efficacy of ADV7103 in maintaining targeted serum bicarbonate levels, preventing metabolic acidosis, and preventing hypokalemia in the following groups o...

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News  226 results

Potassium Abnormalities Boost Hospital Visits for Kidney Disease
https://www.medscape.com/viewarticle/972652

Apr 25th, 2022 - Patients with advanced chronic kidney disease (CKD) are at higher risk of hospitalization or requiring an emergency room (ER) visit in the short-term if they have abnormal potassium levels, a nationally representative cohort of US veterans with ad...

Pegcetacoplan Improves Efficacy in Complement Inhibitor–Naïve Paroxysmal Nocturnal Hemoglobinuria
https://www.onclive.com/view/pegcetacoplan-improves-efficacy-in-complement-inhibitor-na-ve-paroxysmal-nocturnal-hemoglobinuria

Apr 9th, 2022 - Pegcetacoplan (Empaveli) treatment was associated with hemoglobin stabilization and normalization, as well as a superior change from baseline in hemoglobin levels, which showed a meaningful correction of anemia, in patients with complement inhibit...

Avapritinib Approved in Europe for Advanced Systemic Mastocytosis
https://www.onclive.com/view/avapritinib-approved-in-europe-for-advanced-systemic-mastocytosis

Mar 25th, 2022 - The European Commission has expanded the current indication for avapritinib (Ayvakyt) to include use as a single agent in adult patients with aggressive systemic mastocytosis, systemic mastocytosis with an associated hematologic neoplasm, or mast ...

Pembrolizumab Plus Gemcitabine/Hypofractionated Radiotherapy Demonstrates Promising Efficacy in Muscle-Invasive Bladder Cancer
https://www.onclive.com/view/pembrolizumab-plus-gemcitabine-hypofractionated-radiotherapy-demonstrates-promising-efficacy-in-muscle-invasive-bladder-cancer

Mar 1st, 2022 - Pembrolizumab (Keytruda) in combination with gemcitabine and concurrent hypofractionated radiotherapy (RT) appears to be a promising and efficacious, bladder-sparing regimen for patients with muscle-invasive bladder cancer (MIBC), according to fin...

EU Panel Recommends Avapritinib for Advanced Systemic Mastocytosis
https://www.onclive.com/view/eu-panel-recommends-avapritinib-for-advanced-systemic-mastocytosis

Jan 31st, 2022 - The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended to expand the current indication for avapritinib (Ayvakyt) to include use as a single agent in the treatment of adult patients with aggressive sy...

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