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About 1,050 results

ALLMedicine™ Wilson Disease Center

Research & Reviews  388 results

Copper and Molybdenum Balance in Participants With Wilson Disease Treated With ALXN1840
https://clinicaltrials.gov/ct2/show/NCT04573309

May 18th, 2022 - Participants who are treatment experienced (which includes standard-of-care therapies or ALXN1840) and treatment naïve are eligible for this study.

Clinical Study of UX701 AAV-Mediated Gene Transfer for the Treatment of Wilson Disease
https://clinicaltrials.gov/ct2/show/NCT04884815

Apr 28th, 2022 - This study is a randomized, double-blind, placebo-controlled, seamless, adaptive Phase 1/2/3 clinical study of UX701 in patients with Wilson disease. Stage 1 (Phase 1/2) is designed to evaluate the safety and efficacy of 3 dose levels of UX701 to ...

Genetic studies discover novel coding and non-coding mutations in patients with Wilson'...
https://doi.org/10.1002/jcla.24459
Journal of Clinical Laboratory Analysis; Huang C, Fang M et. al.

Apr 27th, 2022 - Wilson disease (WD) is a rare autosomal recessive genetic disorder associated with various mutations in the ATP7B gene and leads to significant disability or death if untreated. Early diagnosis and proper therapy usually predict a good prognosis, ...

Proteinuria in a 6-year-old girl with Wilson disease: Lessons learnt.
https://doi.org/10.1111/jpc.15936
Journal of Paediatrics and Child Health; Narayan A, Karunakar P et. al.

Feb 27th, 2022 - Proteinuria in a 6-year-old girl with Wilson disease: Lessons learnt.|2022|Narayan A,Karunakar P,Krishnamurthy S,Deepthi B,Srinivas BH,|

Wilson disease in Northern Portugal: a long-term follow-up study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867740
Orphanet Journal of Rare Diseases; Garrido I, Marques M et. al.

Feb 25th, 2022 - Wilson disease is an autosomal recessive disease of liver copper metabolism with predominant hepatic and neurological manifestations. Long-term data on the clinical follow-up and treatment efficacy are limited due to the low frequency of the disea...

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Clinicaltrials.gov  9 results

Copper and Molybdenum Balance in Participants With Wilson Disease Treated With ALXN1840
https://clinicaltrials.gov/ct2/show/NCT04573309

May 18th, 2022 - Participants who are treatment experienced (which includes standard-of-care therapies or ALXN1840) and treatment naïve are eligible for this study.

Clinical Study of UX701 AAV-Mediated Gene Transfer for the Treatment of Wilson Disease
https://clinicaltrials.gov/ct2/show/NCT04884815

Apr 28th, 2022 - This study is a randomized, double-blind, placebo-controlled, seamless, adaptive Phase 1/2/3 clinical study of UX701 in patients with Wilson disease. Stage 1 (Phase 1/2) is designed to evaluate the safety and efficacy of 3 dose levels of UX701 to ...

International Wilson's Disease Patient Registry (iWilson Registry)
https://clinicaltrials.gov/ct2/show/NCT05239858

Feb 15th, 2022 - This is a retrospective/prospective observational registry without a control group. A standardised collection tool will be utilised to capture and compare data. The registry will use common data elements, guided by a literature review, and expert ...

The Efficacy and Mechanism of Trientine in Patients With Hypertrophic Cardiomyopathy
https://clinicaltrials.gov/ct2/show/NCT04706429

Mar 17th, 2021 - HCM is the most common inherited cardiovascular disorder. It is characterised by left ventricular (LV) myocardial hypertrophy and fibrosis. Patients can experience symptoms of effort intolerance, progressive heart failure and abnormal heart rhythm...

Pain Scores and Complications do Not Differ at Three Recovery Position After Liver Biopsy
https://clinicaltrials.gov/ct2/show/NCT04750031

Feb 16th, 2021 - Liver biopsy is still used as the gold standard in the diagnosis of many liver diseases. The health practice notification (SUT) makes the diagnosis with liver biopsy mandatory for the treatment of chronic viral hepatitis (Chronic Hepatitis B Inf. ...

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News  17 results

Wilson Disease: Osmosis Study Video
https://www.medscape.com/viewarticle/932327

Jun 19th, 2020 - Wilson disease is an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease. It is the result of inadequate copper excretion into bile and blood, result...

High-calorie diet may worsen Wilson disease
https://www.mdedge.com/gihepnews/article/195884/liver-disease/high-calorie-diet-may-worsen-wilson-disease/page/0/1?channel=69

Mar 7th, 2019 - Copper testing showed that Wilson disease rats fed the high-calorie diet had high serum levels of non–ceruloplasmin-bound copper, which is a sign of overt liver damage; based on histologic findings, the copper likely came from destroyed hepatocyte.

High-calorie diet may worsen Wilson disease
https://www.mdedge.com/gihepnews/article/195884/liver-disease/high-calorie-diet-may-worsen-wilson-disease
Will Pass, MDedge News

Mar 7th, 2019 - A high-calorie diet may cause earlier onset of more severe Wilson disease, according to a rodent study. If translatable to humans, the results could explain “striking phenotype-genotype discrepancies” between patients with Wilson disease, and may.

Wilson Disease: Osmosis Study Video
https://www.medscape.com/viewarticle/908986

Feb 28th, 2019 - What is Wilson disease? Individuals typically take in more copper than the body needs every day, and any excess is excreted. In patients with Wilson disease, a genetic defect affecting the ATP7B transport protein causes copper to accumulate in the...

Biotech M&A rolls on as Alexion snaps up Wilson for $855 million
https://www.reuters.com/article/us-wilson-therapeut-m-a-alexion-pharms/biotech-ma-rolls-on-as-alexion-snaps-up-wilson-for-855-million-idUSKBN1HI236

Apr 11th, 2018 - (Reuters) - Alexion Pharmaceuticals (ALXN.O) has agreed to buy Sweden’s Wilson Therapeutics WTX.ST for 7.1 billion Swedish crowns ($855 million), boosting its line-up of rare disease drugs as a wave of deal-making in the biotechnology sector conti...

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Patient Education  6 results see all →