About 593 results

ALLMedicine™ Agammaglobulinemia Center

Research & Reviews  198 results

Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case S...
Journal of Crohn's & Colitis; Albshesh A, Eder P et. al.

Jul 19th, 2021 - Hypogammaglobulinemia is a disorder characterized by low serum immunoglobulin levels and had high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel...

Common Variable Immunodeficiency and Other Immunodeficiency Syndromes in Bronchiectasis.
Seminars in Respiratory and Critical Care Medicine; McShane PJ

Jul 15th, 2021 - Immunodeficiency represents a vast number of diseases and syndromes. Both primary and secondary forms of immunodeficiency are important contributors to the development of bronchiectasis. Primary immune deficiencies, in particular, are increasingly...

Whole genome sequencing identifies novel structural variant in a large Indian family af...
PloS One; Jain A, Govindaraj GM et. al.

Jul 13th, 2021 - X-linked agammaglobulinemia (XLA, OMIM #300755) is a primary immunodeficiency disorder caused by pathogenic variations in the BTK gene, characterized by failure of development and maturation of B lymphocytes. The estimated prevalence worldwide is ...

Agammaglobulinemia: from X-linked to Autosomal Forms of Disease.
Clinical Reviews in Allergy & Immunology; Cardenas-Morales M, Hernandez-Trujillo VP

Jul 10th, 2021 - Interruptions or alterations in the B cell development pathway can lead to primary B cell immunodeficiency with resultant absence or diminished immunoglobulin production. While the most common cause of congenital agammaglobulinemia is X-linked aga...

Identification of 22 novel BTK gene variants in B cell deficiency with hypogammaglobuli...
Clinical Immunology (Orlando, Fla.); Kraft MT, Pyle R et. al.

Jun 29th, 2021 - X-linked agammaglobulinemia (XLA) is an inborn error of immunity caused by pathogenic variants in the BTK gene, resulting in impaired B cell differentiation and maturation. Over 900 variants have already been described in this gene, however, new p...

see more →

Drugs  22 results see all →

Clinicaltrials.gov  3 results

Safety, Pharmacokinetic and Efficacy Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solution in Patients With Primary Immunodeficiency (Hypo- or Agammaglobulinemia)

Jul 25th, 2019 - The purpose of this study is to determine the pharmacokinetics, efficacy and safety of Immune Globulin Intravenous (Human), 10% TVR (Triple Virally Reduced) Solution in subjects with primary immunodeficiency (PID) manifesting as hypo- or agammaglo...

Assessment of Immunogenicity of Zostavax® in Patients With Antibody Deficiency 60 Years of Age and Older

May 31st, 2018 - Common variable immune deficiency (CVID), specific antibody deficiency (SAD), and X-linked agammaglobulinemia (XLA) are among the most common primary antibody deficiencies in which the mainstay of treatment is gammaglobulin replacement. The use of...

Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia

X-linked agammaglobulinemia (XLA) is a humoral primary immunodeficiency in which affected patients have very low levels of peripheral B cells and a profound deficiency of all immunoglobulin isotypes. Mutations in the gene encoding for Bruton's tyr...

see more →

News  10 results

COVID-19 Outcomes Vary Widely in Patients With Primary Immunodeficiencies

Oct 20th, 2020 - NEW YORK (Reuters Health) - Clinical outcomes of COVID-19 in patients with primary immunodeficiency diseases range from mild illness to death, according to a small case series. "We were first surprised that we had only a few cases considering how ...

Dyspnea and Night Sweats in a 46-Year-Old Man

Jan 15th, 2020 - Which of the following is the most likely diagnosis? Your Peers Chose: Bruton agammaglobulinemia 0% Thymoma 0% Pheochromocytoma 0% Teratoma 0% Discussion The patient in this case was eventually diagnosed with thymoma. Symptoms from a thymoma or th...

IPD in children may be a signal of immunodeficiency
Bianca Nogrady

Oct 3rd, 2019 - Recurrent invasive pneumococcal disease in children could be a signal of underlying primary immunodeficiency, according to a systematic review published in JAMA Pediatrics. Coen Butters, BMed, DCH, of the Royal Children’s Hospital in Melbourne, an.

FDA OKs Immunoglobulin Xembify for Primary Immunodeficiencies

Jul 5th, 2019 - The US Food and Drug Administration (FDA) has approved a 20% immune globulin solution for subcutaneous injection (Xembify, Grifols) to treat primary immunodeficiencies in patients as young as 2 years old, according to a company statement. The appr...

FDA approves IVIG product for PI and chronic ITP
HT Staff

Feb 9th, 2017 - Vials of product Photo by Bill Branson The US Food and Drug Administration (FDA) has approved an intravenous immunoglobulin (IVIG) product (Gammaplex® 10%) for the treatment of primary immunodeficiency (PI) and chronic immune thrombocytopenia (ITP.

see more →

Patient Education  4 results see all →