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About 573 results

ALLMedicine™ Alagille Syndrome Center

Research & Reviews  201 results

Exome-wide assessment of isolated biliary atresia: A report from the National Birth Def...
https://doi.org/10.1002/ajmg.a.63185
American Journal of Medical Genetics. Part A; Sok P, Sabo A et. al.

Mar 22nd, 2023 - The etiology of biliary atresia (BA) is unknown, but recent studies suggest a role for rare protein-altering variants (PAVs). Exome sequencing data from the National Birth Defects Prevention Study on 54 child-parent trios, one child-mother duo, an...

Alagille Syndrome
https://emedicine.medscape.com/article/926678-overview

Mar 22nd, 2023 - Practice Essentials Alagille syndrome (AS) is an autosomal dominant disorder (OMIM 118450) associated with abnormalities of the liver, heart, skeleton, eye, and kidneys and a characteristic facial appearance. [1] In 1973, Watson and Miller reporte...

A Study of TAK-625 for the Treatment of Alagille Syndrome (ALGS)
https://clinicaltrials.gov/ct2/show/NCT05543174

Mar 8th, 2023 - The main aim of the study is to check if TAK-625 improves symptoms of Alagille Syndrome (ALGS), side effect from the study treatment or TAK-625, and how much TAK-625 stays in their blood over time. This will help the study sponsor (Takeda) to work...

Novel intronic JAG1 variant associated with Alagille syndrome in a three-generation Leb...
https://doi.org/10.1097/MCD.0000000000000447
Clinical Dysmorphology; Awwad J, Yammine T et. al.

Feb 14th, 2023 - Novel intronic JAG1 variant associated with Alagille syndrome in a three-generation Lebanese family with variable features.|2023|Awwad J,Yammine T,Hamdar L,Souaid M,Farra C,|genetics,genetics,metabolism,

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Drugs  1 results see all →

Clinicaltrials.gov  13 results

A Study of TAK-625 for the Treatment of Alagille Syndrome (ALGS)
https://clinicaltrials.gov/ct2/show/NCT05543174

Mar 8th, 2023 - The main aim of the study is to check if TAK-625 improves symptoms of Alagille Syndrome (ALGS), side effect from the study treatment or TAK-625, and how much TAK-625 stays in their blood over time. This will help the study sponsor (Takeda) to work...

Atorvastatin Therapy on Xanthoma in Alagille Syndrome
https://clinicaltrials.gov/ct2/show/NCT05488067

Feb 8th, 2023 - Alagille syndrome (ALGS, OMIM 118450) is an important cause of chronic cholestasis in children, and the incidence rate is about 1:30000~1:50000. Most patients with ALGS have hypercholesterolemia. In severe cases, multiple xanthomas can be seen, an...

Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome
https://clinicaltrials.gov/ct2/show/NCT05035030

Oct 18th, 2022 - Approximately 35 sites will be initiated for this study in North America, Europe, Middle East, and Asia Pacific.

Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome
https://clinicaltrials.gov/ct2/show/NCT04674761

Mar 31st, 2022 - Approximately 35 sites will be initiated for this study in North America, Europe, Middle East, and Asia Pacific.

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News  12 results

Child, Teen Deaths Surge; EPA Moves to Limit PFAS in Water; Return of Black Lung
https://www.medpagetoday.com/pediatrics/generalpediatrics/103536

Mar 15th, 2023 - Note that some links may require subscriptions. The mortality rate of children and teens rose sharply in 2020 and 2021, driven by factors unrelated to COVID-19 itself. (JAMA) Drugmaker Novo Nordisk said it will slash its insulin prices, following ...

Entyvio for Kid IBD; Phase III Win in PFIC; Drug Flops for Eosinophilic Esophagitis
https://www.medpagetoday.com/gastroenterology/generalgastroenterology/101455

Oct 27th, 2022 - Vedolizumab (Entyvio) was both safe and effective at inducing clinical remission for kids with inflammatory bowel disease (IBD), especially for those with ulcerative colitis, according to the 14-week VEDOKIDS study. This treatment should be consid...

Predicting Crohn's Relapse; Sex After Hernia Repair; Bacteria and Anti-TNF Response
https://www.medpagetoday.com/gastroenterology/generalgastroenterology/100505

Sep 1st, 2022 - Distinct blood protein profiles may help predict clinical relapse in Crohn's disease patients who stop tumor necrosis factor (TNF) inhibitors, and could help pave the way for non-invasive biomarkers to guide anti-TNF withdrawal. (Gut) What's bette...

IBAT Inhibitors: The Medication That Patients With Pruritus Were Itching to Try
https://www.medscape.com/viewarticle/974182

May 23rd, 2022 - Pruritus is a prime clinical expression of cholestatic diseases in children and adults. In my clinical experience, there was no more poignant depiction of the ravages of cholestatic pruritus than that of an 11-year-old girl with Alagille syndrome ...

YouTube Bans Anti-Vaxxers; UV Disinfection Danger; Beijing's Olympics Rules
https://www.medpagetoday.com/infectiousdisease/covid19/94782

Sep 30th, 2021 - Note that some links may require registration or subscription. Anti-vaccine videos will no longer have a home on YouTube. (Washington Post) EHR data suggested that long COVID affected one in three people who had been infected, and lingering sympto...

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Patient Education  2 results see all →