ALLMedicine™ Alagille Syndrome Center

Mar 22nd, 2023 - The etiology of biliary atresia (BA) is unknown, but recent studies suggest a role for rare protein-altering variants (PAVs). Exome sequencing data from the National Birth Defects Prevention Study on 54 child-parent trios, one child-mother duo, an...

Mar 22nd, 2023 - Practice Essentials Alagille syndrome (AS) is an autosomal dominant disorder (OMIM 118450) associated with abnormalities of the liver, heart, skeleton, eye, and kidneys and a characteristic facial appearance. [1] In 1973, Watson and Miller reporte...

Mar 8th, 2023 - The main aim of the study is to check if TAK-625 improves symptoms of Alagille Syndrome (ALGS), side effect from the study treatment or TAK-625, and how much TAK-625 stays in their blood over time. This will help the study sponsor (Takeda) to work...

Feb 17th, 2023 - This is an open label study where all participants will receive maralixibat treatment.

Feb 14th, 2023 - Novel intronic JAG1 variant associated with Alagille syndrome in a three-generation Lebanese family with variable features.|2023|Awwad J,Yammine T,Hamdar L,Souaid M,Farra C,|genetics,genetics,metabolism,

Mar 8th, 2023 - The main aim of the study is to check if TAK-625 improves symptoms of Alagille Syndrome (ALGS), side effect from the study treatment or TAK-625, and how much TAK-625 stays in their blood over time. This will help the study sponsor (Takeda) to work...

Feb 17th, 2023 - This is an open label study where all participants will receive maralixibat treatment.

Feb 8th, 2023 - Alagille syndrome (ALGS, OMIM 118450) is an important cause of chronic cholestasis in children, and the incidence rate is about 1:30000~1:50000. Most patients with ALGS have hypercholesterolemia. In severe cases, multiple xanthomas can be seen, an...

Oct 18th, 2022 - Approximately 35 sites will be initiated for this study in North America, Europe, Middle East, and Asia Pacific.

Mar 31st, 2022 - Approximately 35 sites will be initiated for this study in North America, Europe, Middle East, and Asia Pacific.

Mar 15th, 2023 - Note that some links may require subscriptions. The mortality rate of children and teens rose sharply in 2020 and 2021, driven by factors unrelated to COVID-19 itself. (JAMA) Drugmaker Novo Nordisk said it will slash its insulin prices, following ...

Oct 27th, 2022 - Vedolizumab (Entyvio) was both safe and effective at inducing clinical remission for kids with inflammatory bowel disease (IBD), especially for those with ulcerative colitis, according to the 14-week VEDOKIDS study. This treatment should be consid...

Sep 1st, 2022 - Distinct blood protein profiles may help predict clinical relapse in Crohn's disease patients who stop tumor necrosis factor (TNF) inhibitors, and could help pave the way for non-invasive biomarkers to guide anti-TNF withdrawal. (Gut) What's bette...

May 23rd, 2022 - Pruritus is a prime clinical expression of cholestatic diseases in children and adults. In my clinical experience, there was no more poignant depiction of the ravages of cholestatic pruritus than that of an 11-year-old girl with Alagille syndrome ...

Sep 30th, 2021 - Note that some links may require registration or subscription. Anti-vaccine videos will no longer have a home on YouTube. (Washington Post) EHR data suggested that long COVID affected one in three people who had been infected, and lingering sympto...