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About 588 results

ALLMedicine™ Congenital Hyperinsulinism Center

Research & Reviews  214 results

The Use of Lanreotide in the Treatment of Congenital Hyperinsulinism.
https://doi.org/10.1210/clinem/dgac322
The Journal of Clinical Endocrinology and Metabolism; Cuff H, Lord K et. al.

May 20th, 2022 - Congenital hyperinsulinism (HI) results in severe, persistent hypoglycemia and is associated with high risk of neurodevelopmental deficits. Sixty percent of HI cases are unresponsive to diazoxide, the only FDA-approved drug. Somatostatin analogs a...

Anxiety, depression, and quality of life in parents of children with congenital hyperin...
https://doi.org/10.1007/s00431-022-04486-9 10.1097/MOP.0000000000000645 10.1016/j.pcl.2015.04.010 10.1530/eje.0.1490043 10.1159/000481774 10.3389/fendo.2017.00156 10.1210/jc.2015-2539 10.3389/fendo.2020.580642 10.1186/s13023-022-02214-y 10.1186/s13023-018-0970-8 10.1093/jpepsy/jsv012 10.1542/peds.2008-0582 10.1002/ppul.21423 10.1037/h0089879 10.1093/jpepsy/jsy075 10.1001/archinte.166.10.1092 10.1016/j.jad.2008.06.026 10.3928/0048-5713-20020901-06 10.1026/0084-5345.31.1.31 10.1055/s-2001-16899 10.1016/j.jad.2016.12.012 10.1007/s10995-014-1445-8 10.1136/thoraxjnl-2014-205983 10.1371/journal.pone.0219888 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2 10.3109/09638288.2015.1060267 10.1016/j.jcf.2008.05.002 10.1007/s00467-010-1540-z 10.1186/1477-7525-11-54 10.1001/archpedi.155.12.1346 10.1111/cch.12546 10.1177/1367493513496668 10.1352/0047-6765(2001)039<0297:EPAWBA>2.0.CO;2 10.1542/peds.103.6.1235 10.1089/jpm.2019.0387 10.1002/1096-911x(20001101)35:5<475::aid-mpo6>3.0.co;2-u 10.1542/peds.113.2.229 10.1136/thoraxjnl-2015-207488 10.1097/MPH.0b013e318157fdac 10.3389/fendo.2019.00670 10.1001/jamanetworkopen.2021.27622
European Journal of Pediatrics; Roeper M, Hoermann H et. al.

May 5th, 2022 - This study aimed to assess mental health, family burden, and quality of life (PQoL) in parents of children with persistent congenital hyperinsulinism (CHI). Forty-eight individual CHI parents (75% female) completed self-reported questionnaires and...

Exendin-(9-39) Effects on Glucose and Insulin in Children With Congenital Hyperinsulini...
https://doi.org/10.2337/dc21-2009
Diabetes Care; Stefanovski D, Vajravelu ME et. al.

Apr 14th, 2022 - The aim of this study was to assess whether exendin-(9-39) will increase fasting and postprandial plasma glucose and decrease the incidence of hypoglycemia in children with hyperinsulinism (HI). This was an open-label, four-period crossover study....

Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism
https://clinicaltrials.gov/ct2/show/NCT04172441

Apr 1st, 2022 - The objective of the trial is to evaluate the efficacy of dasiglucagon in reducing glucose requirements in children with persistent congenital hyperinsulinism (CHI) requiring continuous intravenous (IV) glucose administration to prevent/manage hyp...

Increased referrals for congenital hyperinsulinism genetic testing in children with tri...
https://doi.org/10.1111/pedi.13333
Pediatric Diabetes; Hewat TI, Laver TW et. al.

Mar 17th, 2022 - Hyperinsulinism results from inappropriate insulin secretion during hypoglycaemia. Down syndrome is causally linked to a number of endocrine disorders including Type 1 diabetes and neonatal diabetes. We noted a high number of individuals with Down...

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Clinicaltrials.gov  9 results

Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism
https://clinicaltrials.gov/ct2/show/NCT04172441

Apr 1st, 2022 - The objective of the trial is to evaluate the efficacy of dasiglucagon in reducing glucose requirements in children with persistent congenital hyperinsulinism (CHI) requiring continuous intravenous (IV) glucose administration to prevent/manage hyp...

An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism
https://clinicaltrials.gov/ct2/show/NCT04538989

Jan 25th, 2022 - There is a significant unmet medical need to develop new therapies aimed at preventing chronic recurrent hypoglycemia in congenital HI, the most common cause of persistent hypoglycemia in children. RZ358 is a human mAb that allosterically attenuat...

18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety
https://clinicaltrials.gov/ct2/show/NCT03042416

Jan 10th, 2022 - Single centre prospective cohort phase III study of 18F-DOPA PET/CT imaging in specific patient populations: Pediatric patients with congenital hyperinsulinism Pediatric patients with neuroblastoma Pediatric or Adult patients with suspected extra-...

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism
https://clinicaltrials.gov/ct2/show/NCT05088798

Oct 22nd, 2021 - Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disorder that is the most common cause of permanent hypoglycemia in infants and children. More than 50% of the medically-unresponsive patients have focal disease. Which...

Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity
https://clinicaltrials.gov/ct2/show/NCT00897676

Mar 13th, 2020 - This is a placebo controlled study with randomized crossover design to evaluate the effect of the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin-(9-39), on fasting blood glucose levels, protein-induced hypoglycemia, and fasting toler...

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News  12 results

Early Promise for New Agent in Congenital Hyperinsulinism in Kids
https://www.medscape.com/viewarticle/972526

Apr 21st, 2022 - An investigational glucagon-like peptide-1 (GLP-1) antagonist, exendin-(9-39), prevents fasting and protein-induced hypoglycemia among children with congenital hyperinsulinism, new data suggest.   Results from the open-label crossover phase 2 tria...

Does Neonatal Hypoglycemia Affect Kids' Academic Results Later On?
https://www.medpagetoday.com/endocrinology/generalendocrinology/97805

Mar 22nd, 2022 - Children who experienced low blood sugar as newborns did not have different academic performance results 10 years later compared with those who did not have hypoglycemia, new results from the CHYLD study suggest, conflicting with previous findings...

A 15-Year-Old Girl With Steatorrhea Who Can’t See at Night
https://reference.medscape.com/viewarticle/873001_4

Nov 13th, 2019 - EPI is characterized by a deficiency of the above mentioned exocrine pancreatic enzymes, which results in an inability to digest food properly (maldigestion). Because pancreatic lipase accounts for up to 90% of fat digestion, maldigestion of fat i...

Can You Recognize Insulin Resistance in Children? Do You Need To?
https://www.medscape.com/viewarticle/911550

Apr 12th, 2019 - The International Pediatric Association biennial meeting has long focused on the terrifying list of threats to child health: poverty, malnutrition, vaccine-preventable disease, toxic stress. But this year's meeting, held in Panama City, Panama, Ma...

Conan O’Brien to Host Congenital Hyperinsulinism International Event
https://www.mdedge.com/familymedicine/article/148149/rare-diseases/conan-obrien-host-congenital-hyperinsulinism
Neurology Reviews;

Sep 27th, 2017 - Popular late-night TV talk show host Conan O’Brien will host the 2017 “Sugar Soiree” in New York City on November 19, 2017, to be sponsored by Congenital Hyperinsulinism International. This annual event is a fundraiser for programs to benefit thos.

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