ALLMedicine™ Leukoencephalopathy Center

Feb 17th, 2023 - Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by reactivation of the polyomavirus JC (JCV). Human immunodeficiency virus (HIV) infection is one of the leading causes of PML ...

Feb 15th, 2023 - JC polyomavirus is the causative agent of progressive multifocal leukoencephalopathy (PML), a demyelinating disease resulting from the lytic infection of oligodendrocytes that may develop in immunosuppressed individuals: HIV1 infected or individua...

Feb 12th, 2023 - The JC Polyomavirus (JCPyV) is a virus of global distribution and is usually kept under control by the immune system. In patients with AIDS, a latent JCPyV infection can reactivate and develop into progressive multifocal leukoencephalopathy (PML)....

Feb 9th, 2023 - The most common inherited cause of vascular dementia and stroke, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is caused by mutations in NOTCH3. Post-translationally altered NOTCH3 accumulate...

Feb 3rd, 2023 - Migraine is associated with neuroimaging differences in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). However, it is unknown if migraine-related disability (MRD) or if calcitonin gene-related...

May 5th, 2022 - Most patients with relapsing-remitting multiple sclerosis (RRMS) who are stable on natalizumab (Tysabri, Biogen) administered once every 4 weeks (Q4W) may be able to safely switch to a once every 6 weeks (Q6W) dosing interval with no clinically me...

Mar 19th, 2021 - A 78-year-old man with progressive multiple sclerosis (MS) developed progressive multifocal leukoencephalopathy (PML) after treatment with ocrelizumab (Ocrevus) monotherapy. It is believed to be the first such case. "Notably, the patient had never...

Sep 4th, 2020 - Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the brain that can lead to severe disability or death. Natalizumab has been associated with PML. Risk factors for PML are previous immunosuppression, duration of exp...

Apr 30th, 2020 - The first case of progressive multifocal leukoencephalopathy (PML) directly associated with ocrelizumab occurred in a patient with primary progressive multiple sclerosis (MS) who received 2 years of ocrelizumab monotherapy and had not received pri...

May 6th, 2019 - Philadelphia – Adoptive transfer of donor-derived T cells represents a potentially life-saving treatment of severely immunocompromised patients with progressive multifocal leukoencephalopathy (PML). Courtesy NIH/NINDS Dr.