About 2,960 results

ALLMedicine™ Neural Tube Defects Center

Research & Reviews  932 results

Active Pharmacovigilance Project on the safety profile of Dolutegravir in Brazil.
AIDS Care; Mendes JC, Ceccato MDGB et. al.

May 18th, 2022 - A quantitative descriptive study based on Brazilian Active Pharmacovigilance of Dolutegravir (DTG) Project was performed to describe the adverse drug reactions (ADRs) to DTG reported and to evaluate the noncompleteness of data from DTG active phar...

A Systematic Review of Clinical Guidelines for Preconception Care.
Seminars in Reproductive Medicine; Dorney E, Boyle JA et. al.

May 17th, 2022 - Preconception care (PCC) involves a wide-ranging set of interventions to optimize health prior to pregnancy. These interventions seek to enhance conception rates, pregnancy outcomes, childhood health, and the health of future generations. To assis...

Somatic Development Disorders in Children and Adolescents Affected by Syndromes and Dis...
International Journal of Environmental Research and Publi... Perenc L, Guzik A et. al.

May 15th, 2022 - This study was conducted to evaluate the co-occurrence of hydrocephalus treated/untreated surgically and congenital nervous system disorders or neurological syndromes with symptoms visible since childhood, and with somatic development disorders, b...

Transporters in drug development: International transporter consortium update on emergi...
Clinical Pharmacology and Therapeutics; Zamek-Gliszczynski MJ, Sangha V et. al.

May 14th, 2022 - During its 4th transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up...

The role of Lrp6-mediated Wnt/ß-catenin signaling in the cause and intervention of spin...
Disease Models & Mechanisms; Zhao T, McMahon M et. al.

May 7th, 2022 - Neural tube defects (NTDs) are among common and severe birth defects with poorly understood etiology. Mutations in the Wnt coreceptor LRP6 are associated with NTDs in humans. Either gain-of-function (GOF) or loss-of-function (LOF) mutations of Lrp...

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Guidelines  8 results

Guideline No. 410: Prevention, Screening, Diagnosis, and Pregnancy Management for Fetal...
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Douglas Wilson R, Van Mieghem T et. al.

Nov 20th, 2020 - This revised guideline is intended to provide an update on the genetic aspects, prevention, screening, diagnosis, and management of fetal neural tube defects. Women who are pregnant or may become pregnant. Neural tube defect screening should be of...

ACOG Committee Opinion No. 762 Summary: Prepregnancy Counseling.
Obstetrics and Gynecology;

Dec 24th, 2018 - The goal of prepregnancy care is to reduce the risk of adverse health effects for the woman, fetus, and neonate by working with the woman to optimize health, address modifiable risk factors, and provide education about healthy pregnancy. All those...

Practice Bulletin No. 187: Neural Tube Defects.
Obstetrics and Gynecology;

Dec 1st, 2017 - Neural tube defects (NTDs) are congenital structural abnormalities of the central nervous system and vertebral column. Neural tube defects may occur as an isolated malformation, in combination with other malformations, as part of a genetic syndrom...

Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuplo...
Clinical Biochemistry; Lepage N, Chaudhry A et. al.

Jun 27th, 2012 - The Ontario Prenatal Screening Program (OPSP) follows internationally recognized standardized procedures for laboratories and genetics clinics. However, it has been found that some procedures are subject to interpretation, so the current procedure...

Prenatal screening for fetal aneuploidy in singleton pregnancies.
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Chitayat D, Langlois S et. al.

Jul 14th, 2011 - To develop a Canadian consensus document on maternal screening for fetal aneuploidy (e.g., Down syndrome and trisomy 18) in singleton pregnancies. Pregnancy screening for fetal aneuploidy started in the mid 1960s, using maternal age as the screeni...

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Drugs  79 results see all →

Clinicaltrials.gov  10 results

A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment

May 4th, 2022 - Supplementation with Iron and folate have been part of a worldwide strategy targeting anaemia and neural tube defects for many years. However, vitamin B12 deficiency has received much less attention. High prevalence of deficiency in mothers in the...

B-vitamin Levels and Adverse Pregnancy Outcomes

Oct 12th, 2021 - Folate deficiency can cause severe adverse pregnancy outcomes, such as neural tube defects. Effective folate functioning requires essential metabolic interactions with other B vitamins including vitamin B2, vitamin B3, vitamin B6, and vitamin B12,...

INAS-FOCUS (International Active Surveillance Study - Folate in Oral Contraceptives Utilization Study)

Jul 28th, 2020 - New oral contraceptives (OCs) containing drospirenone (DRSP) or dienogest (DNG)/ethinylestradiol (EE) plus levomefolate calcium (metafolin) have been recently introduced and will be introduced in a number of countries in the near future. Although ...

Genetics of Spina Bifida and Anencephaly

Apr 2nd, 2020 - The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly. Ultimately, this type of research may result in improved diagnosis, impr...

Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study

Mar 3rd, 2020 - Periconceptional folic acid supplements of 400 (Micro) daily prevent neural tube defects (NTD) in offspring. Some data suggest that periconceptional folic acid supplements, folate levels during pregnancy, and/or certain variants in the gene that e...

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News  147 results

Maternal serum lamin A can enable the prediction of adverse pregnancy outcomes

Apr 25th, 2022 - Key clinical point: Maternal serum lamin A (LMNA) could emerge as a potential biomarker for prenatal diagnosis of fetal congenital heart disease (CHD), neural tube defects (NTD), and preeclampsia (PE). Major finding: Significantly lower LMNA level.

Folic Acid Being Added to Some Flour 

Sep 20th, 2021 - Folic acid is to be added to non-wholemeal wheat flour across the UK to help reduce neural tube defects in babies by around 20%, or 200 cases a year. The decision follows a consultation in 2019 and is based on evidence of successful fortification ...

Paternal Preconception Alcohol Consumption Tied to Fetal Birth Defect Risk

Apr 21st, 2021 - (Reuters Health) - Preconception paternal alcohol consumption is associated with an increased risk of fetal birth defects, driven by an elevated risk of clefts in particular, a Chinese study suggests. Researchers examined data on 529,090 couples p...

Folic Acid Supplementation Throughout Pregnancy: Neurocognitive Developmental Benefits for Children

Mar 30th, 2021 - Takeaway Continued folic acid (FA) supplementation in pregnancy beyond the early period currently recommended to prevent neural tube defects (NTD) is beneficial to neurocognitive development in the child.

Another HIV Tivicay Birth Outcome: Better Infant Survival

Mar 15th, 2021 - Infants born to women with HIV who were taking dolutegravir (DTG) plus emtracitabine/tenofovir alafenamide (FTC/TAF) had significantly higher odds of surviving the first 6 months after delivery than infants born to women taking efavirenz-based reg...

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Patient Education  8 results see all →