About 203 results

ALLMedicine™ Tetraploidy Center

Research & Reviews  78 results

Genetic instability from a single S phase after whole-genome duplication.
Nature Gemble S, Wardenaar R et. al.

Apr 1st, 2022 - Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications-doublings of the entire complement of chromosomes-are linked to genetic instability and frequently found in human cancers1-3. I...

Novel insights into the BAP1-inactivated melanocytic tumor.
https://doi.org/10.1038/s41379-021-00976-7 10.1097/PAS.0b013e318263648c 10.1007/s00428-014-1674-7 10.1097/DAD.0000000000001740 10.1097/PAS.0b013e3182498be5 10.1056/NEJMoa1502583 10.1016/j.jaad.2018.05.005 10.1038/ng.910 10.1136/jmedgenet-2011-100156 10.1371/journal.pone.0035295 10.1016/j.ajhg.2013.04.012 10.1038/ng.912 10.1200/JCO.2011.41.2965 10.1097/PAT.0000000000000337 10.1111/cup.12493 10.1001/jamadermatol.2015.1701 10.1097/DAD.0000000000001217 10.1186/1479-5876-10-179 10.1111/cup.13525 10.1097/DAD.0000000000001719 10.1097/DAD.0000000000001499 10.1016/j.humpath.2019.02.009 10.1038/nature19057 10.1093/nar/gkx1153 10.18632/oncotarget.27854 10.1097/PAS.0b013e31824b1efd 10.1016/S0344-0338(98)80074-5 10.1016/j.anndiagpath.2007.03.001 10.1016/j.humpath.2014.10.015 10.1001/jamadermatol.2017.2330 10.1097/PAS.0000000000000209 10.1038/nature22071 10.1016/S0002-9440(10)64609-3 10.1097/DAD.0000000000001795 10.1097/DAD.0000000000001840 10.1038/nrm3979 10.1016/j.jaad.2013.10.032 10.1111/pcmr.12735 10.1038/sj.bjc.6603283 10.1038/nature03890 10.1097/DAD.0000000000001226 10.1038/s41379-019-0384-8 10.1111/cup.12625 10.1097/PAS.0b013e31822678d2 10.1111/cup.14073 10.1073/pnas.152205299 10.1111/cup.13277 10.1111/cup.12133 10.1038/s41379-019-0430-6 10.1038/srep11200 10.1097/PAS.0000000000001458 10.1038/s41379-019-0390-x
Modern Pathology : an Official Journal of the United Stat... Donati M, Martinek P et. al.

Dec 4th, 2021 - BAP1-inactivated melanocytic tumor (BIMT) is a group of melanocytic neoplasms with epithelioid cell morphology molecularly characterized by the loss of function of BAP1, a tumor suppressor gene located on chromosome 3p21, and a mutually exclusive ...

Tipping Cancer Cells Over the Edge: The Context-Dependent Cost of High Ploidy.
Cancer Research; Andor N, Altrock PM et. al.

Nov 18th, 2021 - Tetraploidy is an aneuploidy-permissive condition that can fuel tumorgenesis. The tip-over hypothesis of cytotoxic therapy sensitivity proposes that therapy is effective if it pushes a cell's aneuploidy above a viable tipping point. But elevated a...

Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a ge...
American Journal of Hematology; Renella R, Gagne K et. al.

Oct 23rd, 2021 - Septins play key roles in mammalian cell division and cytokinesis but have not previously been implicated in a germline human disorder. A male infant with severe neutropenia and progressive dysmyelopoiesis with tetraploid myeloid precursors was id...

The prognostic implications of tetraploidy/near-Tetraploidy in acute myeloid leukemia: ...
Leukemia & Lymphoma; Xie J, Nachabe A et. al.

Oct 1st, 2020 - The prognostic significance and optimal management of tetraploidy/near-tetraploidy acute myeloid leukemia (T/NT AML) remains unclear given its limited data. This is especially true after factoring in additional chromosomal alterations, which carry...

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Clinicaltrials.gov  2 results

Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus

Sep 11th, 2014 - PRIMARY OBJECTIVES: I. The primary objective of this study is to demonstrate the safety (i.e., determine the maximum tolerated dose (MTD)) of using Polyphenon E (Poly E) over a six-month period in the management of patients with Barrett's Esophagu...

Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma

Sep 17th, 2013 - OBJECTIVES: Confirm that the management of infants with newly diagnosed stage IV neuroblastoma without MYCN amplification treated with etoposide and carboplatin and cyclophosphamide, doxorubicin, and vincristine followed by surgery does not requir...

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News  1 results

Aspirin Found to Reduce Esophageal Cancer Risk in Barrett's

Mar 1st, 2007 - Action Points Explain to patients who ask that this study is preliminary and that several other types of research, including multicenter randomized trials, are essential before these findings can be applied to patients. Inform interested patients ...

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