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About 250 results

ALLMedicine™ Tetraploidy Center

Research & Reviews  92 results

Disruption of T-box transcription factor eomesa results in abnormal development of medi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980737
PloS One; Song S, Du B et. al.

Mar 3rd, 2023 - Median fins are thought to be ancestors of paired fins which in turn give rise to limbs in tetrapods. However, the developmental mechanisms of median fins remain largely unknown. Nonsense mutation of the T-box transcription factor eomesa in zebraf...

Tetraploidy-linked sensitization to CENP-E inhibition in human cells.
https://doi.org/10.1002/1878-0261.13379
Molecular Oncology; Yoshizawa K, Matsura A et. al.

Jan 24th, 2023 - Tetraploidy is a hallmark of cancer cells, and tetraploidy-selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti-proliferative ...

Neuronal and astrocytic tetraploidy is increased in drug-resistant epilepsy.
https://doi.org/10.1111/nan.12873
Neuropathology and Applied Neurobiology; Sanz-García A, Sánchez-Jiménez P et. al.

Dec 22nd, 2022 - Epilepsy is one of the most prevalent neurological diseases. A third of patients with epilepsy remain drug-resistant. The exact aetiology of drug-resistant epilepsy (DRE) is still unknown. Neuronal tetraploidy has been associated with neuropatholo...

Amp(1q) and tetraploidy are commonly acquired chromosomal abnormalities in relapsed mul...
https://doi.org/10.1111/ejh.13905
European Journal of Haematology; Locher M, Jukic E et. al.

Nov 27th, 2022 - Long-term disease control in multiple myeloma (MM) is typically an unmet medical need, and most patients experience multiple relapses. Fluorescence in situ hybridization (FISH) is the standard technique to detect chromosomal abnormalities (CAs), w...

Near-tetraploid T-cell acute lymphoblastic leukaemia in childhood: Results of the AIEOP...
https://doi.org/10.1016/j.ejca.2022.08.013
European Journal of Cancer (Oxford, England : 1990); Ceppi F, Gotti G et. al.

Sep 17th, 2022 - Near-tetraploidy-defined by DNA index 1.79-2.28 or 81-103 chromosomes-is a rare cytogenetic abnormality observed both in children and adults with T-cell acute lymphoblastic leukaemia (T-ALL) and its prognostic value is not yet determined. We repor...

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Clinicaltrials.gov  5 results

Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus
https://clinicaltrials.gov/ct2/show/NCT00233935

Sep 11th, 2014 - PRIMARY OBJECTIVES: I. The primary objective of this study is to demonstrate the safety (i.e., determine the maximum tolerated dose (MTD)) of using Polyphenon E (Poly E) over a six-month period in the management of patients with Barrett's Esophagu...

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma
https://clinicaltrials.gov/ct2/show/NCT00025610

Sep 17th, 2013 - OBJECTIVES: Confirm that the outcome for infants with newly diagnosed stage IV or IVS neuroblastoma without MYCN amplification is not altered by treatment with etoposide and carboplatin followed by cyclophosphamide, doxorubicin, and vincristine. D...

Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma
https://clinicaltrials.gov/ct2/show/NCT00025623

Sep 17th, 2013 - OBJECTIVES: Confirm that the management of infants with newly diagnosed stage IV neuroblastoma without MYCN amplification treated with etoposide and carboplatin and cyclophosphamide, doxorubicin, and vincristine followed by surgery does not requir...

Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma.
https://clinicaltrials.gov/ct2/show/NCT00025597

Sep 17th, 2013 - OBJECTIVES: Determine the survival and morbidity of infants with newly diagnosed stage II or III unresectable neuroblastoma without MYCN amplification treated with vincristine and cyclophosphamide, etoposide and carboplatin, and cyclophosphamide, ...

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma Who Are Undergoing Surgery With or Without Autologous Bone Marrow or Peripheral Stem Cell Transplant
https://clinicaltrials.gov/ct2/show/NCT00417053

Aug 2nd, 2013 - OBJECTIVES: Primary Determine the outcome, in terms of survival and morbidity, in infants with localized, unresectable, non-MYCN-amplified neuroblastoma treated with reduced-intensity chemotherapy. Determine the survival of infants with stage 4S n...

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News  3 results

Frontline Therapy for Patients With CLL: Testing and Risk Classification
https://www.onclive.com/view/frontline-therapy-for-patients-with-cll-testing-and-risk-classification

Aug 9th, 2021 - Anna Schuh, MD, PhD: The ESMO [European Society for Medical Oncology] Clinical Practice Guidelines from 2021 that just came out recommend both testing for the immunoglobulin status and for the TP53 mutation and 17p deletion. The immunoglobulin sta...

Bladder Cancer Biomarkers Aid in Diagnosis, Monitoring
https://www.onclive.com/view/bladder-cancer-biomarkers-aid-in-diagnosis-monitoring

Dec 20th, 2020 - Badrinath Konety, MD, MBA When it comes to the burgeoning arena of biomarkers in bladder cancer, the value proposition is compelling, although the utility and costs need to be better defined, said Badrinath Konety, MD, MBA, department chair of ur...

Aspirin Found to Reduce Esophageal Cancer Risk in Barrett's
https://www.medpagetoday.com/hematologyoncology/othercancers/5167

Mar 1st, 2007 - Action Points Explain to patients who ask that this study is preliminary and that several other types of research, including multicenter randomized trials, are essential before these findings can be applied to patients. Inform interested patients ...

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