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About 790 results

ALLMedicine™ Adult-onset Still's Disease Center

Research & Reviews  293 results

New onset and flare of rheumatic diseases following COVID-19 vaccination are mild and r...
https://doi.org/10.55563/clinexprheumatol/vx44zn
Clinical and Experimental Rheumatology; Gasparotto M, Bindoli S et. al.

Aug 6th, 2022 - Anti-COVID-19 vaccines have proved to be effective and well tolerated. Great attention is now being paid to the characterisation of possible adverse events associated to their administration. We report a case series of suspected rheumatic diseases...

JAK inhibitors in difficult-to-treat adult-onset Still's disease and systemic-onset juv...
https://doi.org/10.1093/rheumatology/keac440
Rheumatology (Oxford, England); Gillard L, Pouchot J et. al.

Aug 4th, 2022 - Excessive and inappropriate production of pro-inflammatory cytokines plays a key role in Still's disease. JAK inhibitor (JAKi) agents mainly block pro-inflammatory cytokine pathways, notably IL-6 and IFN. The objective was to assess the efficacy a...

Rheumatic disorders among patients with fever of unknown origin: A systematic review an...
https://doi.org/10.1016/j.semarthrit.2022.152066
Seminars in Arthritis and Rheumatism; Betrains A, Moreel L et. al.

Jul 23rd, 2022 - To conduct a systematic literature review and meta-analysis to estimate the proportion of fever of unknown origin (FUO) and inflammation of unknown origin (IUO) cases that are due to rheumatic disorders and the relative frequency of specific entit...

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
https://clinicaltrials.gov/ct2/show/NCT03510442

Jul 22nd, 2022 - The purpose of this protocol is to study the natural history, genetics and pathophysiology of systemic juvenile idiopathic arthritis (sJIA), adult-onset Still s disease (AOSD) and related inflammatory conditions. One of seven subtypes of juvenile ...

The clinical heterogeneity of adult onset Still's disease may underlie different pathog...
https://doi.org/10.1016/j.smim.2022.101632
Seminars in Immunology; Ruscitti P, Berardicurti O et. al.

Jul 6th, 2022 - Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown aetiology usually affecting young adults and manifesting with a clinical triad of spiking fever, arthritis, and evanescent cutaneous rash. AOSD may be considered a highly...

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Clinicaltrials.gov  13 results

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
https://clinicaltrials.gov/ct2/show/NCT03510442

Jul 22nd, 2022 - The purpose of this protocol is to study the natural history, genetics and pathophysiology of systemic juvenile idiopathic arthritis (sJIA), adult-onset Still s disease (AOSD) and related inflammatory conditions. One of seven subtypes of juvenile ...

Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE
https://clinicaltrials.gov/ct2/show/NCT05001737

Jun 30th, 2022 - Study NI-0501-14 is a two-cohort trial that enrolls subjects who are diagnosed with sHLH/MAS (MAS being a form of secondary HLH) and who are presenting an inadequate response to high doses of GCs. These subjects will be enrolled in 2 cohorts as pe...

A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing M...
https://clinicaltrials.gov/ct2/show/NCT03311854

May 17th, 2022 - Macrophage Activation Syndrome (MAS) is a rare, life-threatening condition characterized by uncontrolled hyperinflammation which may develop on the background of systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD). ...

Treatment of Macrophage Activation Syndrome (MAS) With Anakinra
https://clinicaltrials.gov/ct2/show/NCT02780583

Jan 4th, 2022 - Macrophage activation syndrome (MAS) is a disorder whereby the immune system generates very high levels of substances (cytokines) that promote inflammation to the extent dysfunction occurs in multiple organ systems which if unchecked, is frequentl...

Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals
https://clinicaltrials.gov/ct2/show/NCT05102695

Nov 5th, 2021 - Inflammatory markers are often elevated in patients with COVID-19, notably C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), IL-6and ferritin. Multiple prior studies have found correlations between various biomarkers and clinical out...

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News  10 results

NICE Recommends Anakinra for Paediatric and Adult-onset Still’s Disease
https://www.medscape.com/viewarticle/948506

Apr 1st, 2021 - The National Institute for Health and Care Excellence (NICE) has recommended anakinra (Kineret, Swedish Orphan Biovitrum) as a treatment option for Still’s disease in adults and systemic juvenile idiopathic arthritis in children. Anakinra is an in...

FDA Approves Canakinumab (Ilaris), First Drug for Adult-Onset Still's Disease
https://www.medscape.com/viewarticle/932625

Jun 19th, 2020 - The Food and Drug Administration has expanded the indications for canakinumab (Ilaris) to include all patients with active Still's disease older than 2 years, adding adult-onset Still's disease (AOSD) to a previous approval for juvenile-onset Stil...

Rheumatologists: On the COVID-19 Front Line
https://www.medpagetoday.com/infectiousdisease/covid19/85545

Mar 22nd, 2020 - Rheumatologists may be in a unique position to consult and help in the management of patients with severe disease caused by COVID-19, said experts. "Some of the drugs that appear promising for patients who are severely ill with COVID-19 are those ...

Lethal Lung Disease and Biologics: Is There a Link?
https://www.medpagetoday.com/rheumatology/arthritis/81966

Sep 4th, 2019 - A new, potentially life-threatening parenchymal lung disease is increasingly being detected in patients with systemic juvenile idiopathic arthritis (sJIA), according to recent reports. Systemic JIA is distinct from other forms of JIA in that the a...

IL-6 for Adult Still's: A New Option?
https://www.medpagetoday.com/rheumatology/generalrheumatology/75699

Oct 14th, 2018 - Action Points Some clinical benefits were seen among patients with adult-onset Still's disease treated with tocilizumab (Actemra) in a small clinical trial, but the study's primary endpoint was not met. During the double-blind part of the trial, t...

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