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About 3,320 results

ALLMedicine™ Congenital Adrenal Hyperplasia Center

Research & Reviews  806 results

Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia
https://clinicaltrials.gov/ct2/show/NCT00001521

May 20th, 2022 - To test the hypothesis that the regimen of flutamide (an antiandrogen), testolactone or letrozole (an inhibitor of androgen-to-estrogen conversion), and reduced hydrocortisone dose can normalize the growth and adult stature of children with congen...

Ovarian and paraovarian adrenal rest tumors are not uncommon in gonadectomy materials o...
https://doi.org/10.1530/EJE-21-0913
European Journal of Endocrinology; Yildiz M, Bayram A et. al.

May 14th, 2022 - The aim of this study was to assess the prevalence of ovarian and paraovarian adrenal rest tumors (ARTs) in gonadectomy materials of a subgroup of congenital adrenal hyperplasia (CAH) patients. A total of 20 historical cases with clinical/molecula...

17-Ketosteroids
http://emedicine.medscape.com/article/2089246-overview

May 13th, 2022 - Reference Range The reference range of urinary 17-ketosteroids is as follows [1] : Males: 10-20 mg (34-69 µmol)/24 h Females: 5-15 mg (17-52 µmol)/24 h Next: Interpretation Increases in levels of 24-hour urinary 17-ketosteroids are associated with...

17-Ketosteroids
https://emedicine.medscape.com/article/2089246-overview

May 13th, 2022 - Reference Range The reference range of urinary 17-ketosteroids is as follows [1] : Males: 10-20 mg (34-69 µmol)/24 h Females: 5-15 mg (17-52 µmol)/24 h Next: Interpretation Increases in levels of 24-hour urinary 17-ketosteroids are associated with...

11-Deoxycortisol
https://emedicine.medscape.com/article/2088937-print

May 13th, 2022 - The serum reference ranges of 11-deoxycortisol are as follows[1, 2, 3] : Persons aged 18 years or younger: < 344 ng/dL Adults older than 18 years: 10-79 ng/dL Ranges decrease with age after puberty Serum reference range of 11-deoxycortisol after a...

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Guidelines  2 results

Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456929
The Journal of Clinical Endocrinology and Metabolism; Speiser PW, Arlt W et. al.

Oct 3rd, 2018 - To update the congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency clinical practice guideline published by the Endocrine Society in 2010. The writing committee presents updated best practice guidelines for the clinical manageme...

Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936060
The Journal of Clinical Endocrinology and Metabolism; Speiser PW, Azziz R et. al.

Sep 9th, 2010 - We developed clinical practice guidelines for congenital adrenal hyperplasia (CAH). The Task Force included a chair, selected by The Endocrine Society Clinical Guidelines Subcommittee (CGS), ten additional clinicians experienced in treating CAH, a...

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Drugs  449 results see all →

Clinicaltrials.gov  25 results

Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia
https://clinicaltrials.gov/ct2/show/NCT00001521

May 20th, 2022 - To test the hypothesis that the regimen of flutamide (an antiandrogen), testolactone or letrozole (an inhibitor of androgen-to-estrogen conversion), and reduced hydrocortisone dose can normalize the growth and adult stature of children with congen...

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 in Adults With Congenital Adrenal Hyperplasia
https://clinicaltrials.gov/ct2/show/NCT03525886

May 3rd, 2022 - This is a Phase 2, open-label, multiple-dose, dose-escalation study to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of NBI-74788 in up to 30 adult female and male subjects (18 to 50 years of age) with a documen...

Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Patients With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
https://clinicaltrials.gov/ct2/show/NCT04806451

Apr 11th, 2022 - This is a Phase 3 study to evaluate the efficacy, safety, and tolerability of crinecerfont versus placebo administered for 28 weeks in approximately 81 pediatric patients with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase defi...

Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1
https://clinicaltrials.gov/ct2/show/NCT02574910

Feb 24th, 2022 - Congenital adrenal hyperplasia (CAH) is an inherited inability to synthesize cortisol in the adrenal gland. More than 90% of cases are cause by deficiency of steroid 21-hydroxylase (CYP21, also termed CYP21A2, P450c21), which is a cytochrome P450 ...

Androgen Reduction in Congenital Adrenal Hyperplasia
https://clinicaltrials.gov/ct2/show/NCT03548246

Dec 20th, 2021 - Congenital adrenal hyperplasia (CAH) is an inherited inability to synthesize cortisol in the adrenal gland. More than 90% of cases are cause by deficiency of steroid 21-hydroxylase (CYP21, also termed CYP21A2, P450c21), which is a cytochrome P450 ...

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News  42 results

Expert Clarifies Guidance on Adolescent Polycystic Ovary Syndrome
https://www.medscape.com/viewarticle/934155

Jul 17th, 2020 - A trio of international expert recommendations mainly agree on essentials for the diagnosis and treatment of polycystic ovary syndrome in adolescents, but some confusion persists, according to Robert L. Rosenfield, MD, of the University of Califor...

A 16-Year-Old With Amenorrhea and Delayed Breast Development
https://reference.medscape.com/viewarticle/923606_3

Jan 14th, 2020 - Discussion The case patient is a 16-year-old girl who has yet to reach menarche, 3.5 years after the start of breast development. Primary amenorrhea is defined as the lack of menses by age 15 years or more than 3 years after the initiation of seco...

Polycystic Ovary Syndrome: 5 Things You Might Not Know
https://www.staging.medscape.com/viewarticle/916211

Aug 2nd, 2019 - More than 80 years ago, physician colleagues Irving Stein and Michael Leventhal noticed a pattern among some of the infertile women with menstrual irregularities they were seeing in their practice. They published their observations in a landmark r...

ENDO 2019: 5 Key Takeaways in Pediatric Endocrinology
https://www.medscape.com/viewarticle/911873

May 8th, 2019 - Vaneeta Bamba, MD A range of presentations at the 2019 Endocrine Society Annual Meeting focused on issues that affect growth and health in individuals with endocrine disorders. To summarize the key takeaways from this plethora of new information, ...

ENDO 2019: 5 Key Takeaways in Pediatric Endocrinology
https://www.staging.medscape.com/viewarticle/911873

May 8th, 2019 - Vaneeta Bamba, MD A range of presentations at the 2019 Endocrine Society Annual Meeting focused on issues that affect growth and health in individuals with endocrine disorders. To summarize the key takeaways from this plethora of new information, ...

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Patient Education  4 results see all →