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About 2,443 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  830 results

Pharmacogenomics of hydroxyurea therapy and fetal hemoglobin (HbF) levels in sickle cel...
https://doi.org/10.2217/pgs-2022-0050
Pharmacogenomics Sales RR, Nogueira BL et. al.

May 14th, 2022 - Pharmacogenomics of hydroxyurea therapy and fetal hemoglobin (HbF) levels in sickle cell anemia.|2022|Sales RR,Nogueira BL,Luizon MR,|

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT00011648

May 13th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults Wi...
https://doi.org/10.1161/STROKEAHA.121.036567
Stroke Wang Y, Guilliams KP et. al.

May 13th, 2022 - Individuals with sickle cell anemia have heightened risk of stroke and cognitive dysfunction. Given its high prevalence globally, whether sickle cell trait (SCT) is a risk factor for neurological injury has been of interest; however, data have bee...

Arginine Therapy and Cardiopulmonary Hemodynamics in Hospitalized Children with Sickle ...
https://doi.org/10.1164/rccm.202108-1930OC
American Journal of Respiratory and Critical Care Medicine; Onalo R, Cilliers A et. al.

Apr 16th, 2022 - Acute changes in cardiopulmonary hemodynamics that include tricuspid-regurgitant-jet-velocity elevation measured by Doppler-echocardiography are often encountered during sickle cell vaso-occlusive pain and acute chest syndrome. Arginine and nitric...

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Guidelines  1 results

Cardiovascular function and treatment in β-thalassemia major: a consensus statement fro...
https://doi.org/10.1161/CIR.0b013e31829b2be6
Circulation Pennell DJ, Udelson JE et. al.

Jun 19th, 2013 - This aim of this statement is to report an expert consensus on the diagnosis and treatment of cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover other hemoglobinopathies, including thalassemia intermedia and s...

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Drugs  3 results see all →

Clinicaltrials.gov  45 results

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT00011648

May 13th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT04380610

Apr 12th, 2022 - 200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, t...

An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT04053803

Mar 4th, 2022 - This is an open-label extension study of IMR-687 in adult patients with SCA who were previously participants in the Phase 2a study titled "A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study of IMR-687 in Adult Patients with Sickle Cell...

Red Blood Cell Exchange Transfusion as a Novel Treatment for GLUT1 Deficiency Syndrome
https://clinicaltrials.gov/ct2/show/NCT04137692

Jan 3rd, 2022 - As the transporter responsible for basal levels of glucose flux, Glucose transporter 1 (GLUT1) is expressed at low levels in most tissues. In contrast, GLUT1 is very highly expressed on human erythrocytes. Human erythrocytes possess up to 5x105 co...

Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
https://clinicaltrials.gov/ct2/show/NCT02149537

Dec 1st, 2021 - The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia. Although HU is used to tre...

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News  90 results

Longer Hydroxyurea Tied to Improved Sickle-Cell Heart Issues
https://www.medpagetoday.com/hematologyoncology/hematology/94540

Sep 16th, 2021 - Prolonged treatment with hydroxyurea may improve -- and possibly even reverse -- cardiac complications in pediatric patients with sickle cell anemia, a retrospective study found. Those on hydroxyurea for less than 1 year had a significantly greate...

Sickle Cell Disease Tied to COVID-19 Mortality, Hospitalizations
https://www.medpagetoday.com/hematologyoncology/hematology/93683

Jul 21st, 2021 - Sickle cell disease (SCD) was associated with a significantly increased risk of COVID-19-related hospitalization and death in adults, U.K. researchers found. Their cohort study showed that having SCD quadrupled a person's risk for COVID-19-related...

Transfusion Dependence in Adult Sickle Cell Anemia
https://www.onclive.com/view/transfusion-dependence-in-adult-sickle-cell-anemia

Apr 2nd, 2021 - Transfusion is 1 of 2 disease-modifying therapies for adults with sickle cell anemia, the other being hydroxyurea, explains Morey Blinder, MD. There are several indications for transfusion in patients with sickle cell disease, with the best studie...

Emotions, worse attention linked to pain-related health care use in SCD
https://www.mdedge.com/hematology-oncology/article/233208/anemia/emotions-worse-attention-linked-pain-related-health-care
Neil Osterweil

Dec 9th, 2020 - The cognitive and emotional status of children with sickle cell disease (SCD) appears to have a significant effect on how they cope with pain and use health care resources, investigators have found. Results of a retrospective study of 112 children.

(Never) A Typical Day in the Life of a Pediatric Hematologist/Oncologist
https://www.onclive.com/view/never-a-typical-day-in-the-life-of-a-pediatric-hematologistoncologist

Dec 5th, 2020 - It seems the older I get, the more frequently high school students, undergraduates, medical students, or residents drop by my office to talk about career choices, inquire about shadowing, or request an interview for a school project. Tell me about...

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Patient Education  8 results see all →